暴露于慢性压力会损害记忆。此外,艾司西酞普兰对记忆的影响仍然自相矛盾。因此,这项研究调查了长时间服用艾司西酞普兰如何影响输入输出(I/O)功能,成对脉冲比(PPR),在接受可预测和不可预测的慢性轻度应激(PCMS和UCMS,分别)。雄性大鼠随机分为对照组(Co),sham(Sh),PCMS和UCMS(PSt和USt,分别为2小时/天,连续21天),艾司西酞普兰(Esc;10mg/kg,i.p.,21天),以及PCMS和UCMS与艾司西酞普兰(PSt-Esc和USt-Esc,分别)。fEPSP斜率,振幅,使用I/O功能评估海马CA1区的曲线下面积(AUC),PP回应,和LTP。在所有实验动物中定量血清皮质酮(CORT)水平。斜坡,振幅,和I/O函数中fEPSP的AUC,在USt和PSt组中,LTP诱导前后的所有三个PP阶段均显着下降。艾司西酞普兰显着增强了PSt-Esc中的这些参数,但不在USt-Esc组.血清CORT水平证实了实验组的电生理发现。PCMS和UCMS都损害了神经兴奋性,神经传递,和记忆在海马CA1区。艾司西酞普兰仅在PCMS下改善记忆障碍,可能归因于血清CORT水平降低。然而,对神经兴奋性没有影响,神经传递,在UCMS下观察到记忆。这表明可能需要不同的艾司西酞普兰剂量来改善对各种类型的慢性轻度应激的同时机制。
Exposure to chronic stress impairs memory. Also, escitalopram\'s impact on memory remains paradoxical. Therefore, this study examined how prolonged escitalopram administration affects input-output (I/O) functions, paired-pulse ratio (PPR), and long-term potentiation (LTP) in the hippocampal CA1 area in rats that underwent predictable and unpredictable chronic mild stress (PCMS and UCMS, respectively). Male rats were randomly assigned to different groups of control (Co), sham (Sh), PCMS and UCMS (PSt and USt, respectively; 2 h/day, for 21 consecutive days), escitalopram (Esc; 10 mg/kg, i.p., for 21 days), as well as PCMS and UCMS with escitalopram (PSt-Esc and USt-Esc, respectively). The fEPSP slope, amplitude, and area under the curve (AUC) were assessed in the hippocampal CA1 area using I/O functions, PP responses, and LTP. Serum corticosterone (CORT) levels were quantified in all experimental animals. The slope, amplitude, and AUC of fEPSP in the I/O functions, and all three PP phases prior and subsequent to LTP induction significantly declined in the USt and PSt groups. Escitalopram significantly enhanced these parameters in the PSt-Esc, but not in the USt-Esc group. Serum CORT levels corroborated the electrophysiological findings among experimental groups. Both PCMS and UCMS impaired neural excitability, neurotransmission, and memory within the hippocampal CA1 area. Escitalopram improved memory impairment only under PCMS, potentially attributed to reduced serum CORT levels. However, no influence on neural excitability, neurotransmission, and memory was observed under UCMS. This suggests different escitalopram doses might be required to ameliorate simultaneous mechanisms in response to various types of chronic mild stress.