■检查无散瞳DRITritonSS-OCT的图像处理(TopconCorporation,东京,日本)使用无红色过滤器可以评估脉络膜结节的存在,因此将其检测作为1型神经纤维瘤病(NF1)的诊断标准。
■我们纳入了210名患者的417只眼,377-来自根据美国国立卫生研究院共识发展会议(NIH)建立的标准诊断为NF1的190名患者,以及来自20名健康患者的40名作为对照组。平均年龄为9.4岁(范围2岁-18岁)。所有患者都通过年龄测试来测量他们的视力,检查是否存在裂隙结节,并对黄斑区进行光学相干断层扫描(OCT)。分析所有OCT图像以检查是否可以识别可见结节。
■14岁(95%CI=(9.7,18.3))和12岁(95%CI=(9.1,14))是用TritonOCT和裂隙灯分离脉络膜结节的分界点。分别,从那些没有。在50%的NF1患者中检测到李奇结节。脉络膜结节的存在与视路胶质瘤的发生(p=0.96)或患者的视力恶化(p=0.072)均无统计学意义。在脉络膜结节的存在和裂隙结节的存在之间观察到统计学上显著的相关性(p<0.05)。
■TopconTritonOCT无红色工具将不是检测NF1患者脉络膜结节的良好工具,因为其灵敏度低。如果脉络膜结节的存在包括在NF1的诊断标准中,则使用具有红色和红外辐射的设备将很方便。
UNASSIGNED: To examine whether image processing of non-mydriatic DRI Triton SS-OCT (Topcon Corporation, Tokyo, Japan) using the red free filter could assess the presence of choroidal nodules and thus include their detection as a diagnostic criterion in neurofibromatosis type 1 (NF1).
UNASSIGNED: We included 417 eyes from 210 patients, 377 - from 190 patients diagnosed with NF1 according to the criteria established by the National Institutes of Health Consensus Development Conference (NIH) and 40 from 20 healthy patients as a control group. The mean age was 9.4 years (range 2 years-18 years). All patients had their visual acuity measured by a test according to age, were examined for the presence of lisch nodules and an Optical Coherence Tomography (OCT) of the macular area was performed. All the OCT images were analysed to check if visible nodules could be identified.
UNASSIGNED: Ages 14 (95% CI=(9.7,18.3)) and 12 years (95% CI=(9.1,14)) are the cut-off points that best separate those with choroidal nodules with Triton OCT and lisch with slit lamp, respectively, from those without. lisch nodules were detected in 50% of cases of NF1 patients. The presence of choroidal nodules did not present a statistically significant correlation with the occurrence of optic pathway glioma (p = 0.96) nor with the patient\'s visual worsening (p = 0.072). A statistically significant correlation was observed between the presence of choroidal nodules and the presence of lisch nodules (p < 0.05).
UNASSIGNED: The Topcon Triton OCT red free tool would not be a good tool to detect choroidal nodules in patients with NF1 because of its low sensitivity. If the presence of choroidal nodules were to be included in the diagnostic criteria for NF1, it would be convenient to use a device with red and infrared radiations.