■2型糖尿病(T2DM)占糖尿病病例的90%,以及它的患病率和发病率,包括合并症,正在全球崛起。临床上,糖尿病和相关的合并症通过生化和物理特征来识别,包括血糖,糖化血红蛋白(HbA1c),和心血管测试,眼睛和肾脏疾病。
糖尿病可能具有基于炎症和氧化应激的共同病因,这可能提供有关疾病进展和治疗选择的其他信息。因此,识别高危人群可以延缓或预防糖尿病及其并发症.
■在有或没有高血压和心血管疾病的患者中,作为从无糖尿病到T2DM进展的一部分,这项研究研究了控制和糖尿病前期之间生物标志物的变化,前驱糖尿病到T2DM,并控制到T2DM,并根据首次就诊数据对患者进行分类。控制患者和高血压患者,心血管,高血压和心血管疾病分别为156、148、61和216。
■线性判别分析用于分类方法和特征重要性,这项研究检查了Humanin与线粒体蛋白(MOTSc)之间的关系,与氧化应激相关的线粒体肽,糖尿病进展,和相关的并发症。
■MOTSc,还原型谷胱甘肽和谷胱甘肽二硫化物比值(GSH/GSSG),白细胞介素-1β(IL-1β),和8-异前列腺素对于从糖尿病前期到t2dm的过渡是显着的(P<0.05),强调线粒体参与的重要性。补体成分5a(c5a)是与疾病进展和合并症相关的生物标志物,gshgssg,单核细胞趋化蛋白-1(mcp-1),8-异前列腺素是最重要的生物标志物。
■随着糖尿病的进展,合并症会影响假设的生物标志物。线粒体氧化应激指标,凝血,和炎症标志物有助于评估糖尿病疾病的发展并提供适当的药物。未来的研究将检查纵向生物标志物的演变。
UNASSIGNED: Type 2 diabetes mellitus (T2DM) are 90% of diabetes cases, and its prevalence and incidence, including comorbidities, are rising worldwide. Clinically, diabetes and associated comorbidities are identified by biochemical and physical characteristics including glycemia, glycated hemoglobin (HbA1c), and tests for cardiovascular, eye and kidney disease.
UNASSIGNED: Diabetes may have a common etiology based on inflammation and oxidative stress that may provide additional information about disease progression and treatment options. Thus, identifying high-risk individuals can delay or prevent diabetes and its complications.
UNASSIGNED: In patients with or without hypertension and cardiovascular disease, as part of progression from no diabetes to T2DM, this research studied the changes in biomarkers between control and prediabetes, prediabetes to T2DM, and control to T2DM, and classified patients based on first-attendance data. Control patients and patients with hypertension, cardiovascular, and with both hypertension and cardiovascular diseases are 156, 148, 61, and 216, respectively.
UNASSIGNED: Linear discriminant analysis is used for classification method and feature importance, This study examined the relationship between Humanin and mitochondrial protein (MOTSc), mitochondrial peptides associated with oxidative stress, diabetes progression, and associated complications.
UNASSIGNED: MOTSc, reduced glutathione and glutathione disulfide ratio (GSH/GSSG), interleukin-1β (IL-1β), and 8-isoprostane were significant (P < .05) for the transition from prediabetes to t2dm, highlighting importance of mitochondrial involvement. complement component 5a (c5a) is a biomarker associated with disease progression and comorbidities, gsh gssg, monocyte chemoattractant protein-1 (mcp-1), 8-isoprostane being most important biomarkers.
UNASSIGNED: Comorbidities affect the hypothesized biomarkers as diabetes progresses. Mitochondrial oxidative stress indicators, coagulation, and inflammatory markers help assess diabetes disease development and provide appropriate medications. Future studies will examine longitudinal biomarker evolution.