未经证实:特发性正常压力性脑积水(iNPH)是导致认知功能障碍和步态障碍的主要可逆原因,其临床表现与老年人的主要神经退行性疾病相似,并伴随着这些疾病。我们旨在研究阿尔茨海默病(AD)的脑脊液(CSF)生物标志物是否可用于iNPH的鉴别诊断。
未经证实:淀粉样蛋白-β(Aβ)42和40,总tau(t-tau),通过ELISA在192例iNPH患者(n=80)的连续CSF样本中测量磷酸化tau(p-tau),AD(n=48),额颞叶痴呆(FTD)(n=34),路易体病(LBDs)(n=30),包括帕金森病痴呆和路易体痴呆。
未经评估:研究人群的平均年龄为75.6±7.7岁,54.2%为女性。脑脊液Aβ42水平明显增高,iNPH患者的p-tau和t-tau水平低于AD和LBD患者。此外,iNPH患者的t-tau水平明显高于FTD患者。年龄和性别调整的多元回归分析显示,当Aβ42水平增加一个标准差(SD)时,相对于iNPH患有AD的几率降低了37%,LBD相对于iNPH的几率降低了47%。当p-tau水平增加1SD时,相对于iNPH具有LBD的几率增加76%。当t-tau值增加1SD时,患者相对于NPH具有LBD的可能性是2.5倍,并且相对于iNPH具有AD的可能性是2.1倍。
未经证实:我们的结果表明,脑脊液Aβ42,p-tau,还有t-tau,在特别减少的t-tau中,在区分iNPH与LBD方面具有潜在价值,并且还证实了先前的研究报告iNPH中的t-tau水平较低,Aβ42水平高于AD。
UNASSIGNED: Idiopathic normal pressure hydrocephalus (iNPH) is the leading reversible cause of cognitive impairment and gait disturbance that has similar clinical manifestations and accompanies to major neurodegenerative disorders in older adults. We aimed to investigate whether cerebrospinal fluid (CSF) biomarker for Alzheimer\'s disease (AD) may be useful in the differential diagnosis of iNPH.
UNASSIGNED: Amyloid-beta (Aß) 42 and 40, total tau (t-tau), phosphorylated tau (p-tau) were measured via ELISA in 192 consecutive CSF samples of patients with iNPH (n=80), AD (n=48), frontotemporal dementia (FTD) (n=34), Lewy body diseases (LBDs) (n=30) consisting of Parkinson\'s disease dementia and dementia with Lewy bodies.
UNASSIGNED: The mean age of the study population was 75.6±7.7 years, and 54.2% were female. CSF Aβ42 levels were significantly higher, and p-tau and t-tau levels were lower in iNPH patients than in those with AD and LBDs patients. Additionally, iNPH patients had significantly higher levels of t-tau than those with FTD. Age and sex-adjusted multi-nominal regression analysis revealed that the odds of having AD relative to iNPH decreased by 37% when the Aβ42 level increased by one standard deviation (SD), and the odds of having LBDs relative to iNPH decreased by 47%. The odds of having LBDs relative to iNPH increased 76% when the p-tau level increased 1SD. It is 2.5 times more likely for a patient to have LBD relative to NPH and 2.1 times more likely to have AD relative to iNPH when the t-tau value increased 1SD.
UNASSIGNED: Our results suggest that levels of CSF Aβ42, p-tau, and t-tau, in particularly decreased t-tau, are of potential value in differentiating iNPH from LBDs and also confirm previous studies reporting t-tau level is lower and Aβ42 level is higher in iNPH than in AD.