■左甲状腺素治疗对甲状腺功能减退患者血脂的影响导致心血管疾病和死亡率的风险降低。
■明显或亚临床甲状腺功能减退会对脂质代谢产生负面影响,并导致高胆固醇血症,进而增加心血管疾病和死亡率的风险。在这件事上,几项介入研究调查了左甲状腺素治疗对甲状腺功能减退患者血脂的影响,并获得了相互矛盾的结果。本研究旨在探讨左甲状腺素替代治疗对甲减患者胆固醇水平的影响。
■本前瞻性研究检查了112例明显甲状腺功能减退症患者(平均年龄43.80±14.36岁)。要做到这一点,72.3%的患者为女性。左甲状腺素替代疗法是为患者开的,每月对其进行检查以评估治疗对其血脂状况的影响。在达到正常的促甲状腺激素(TSH)后,患者的实验室参数,包括TSH,总胆固醇,低密度脂蛋白(LDL)胆固醇,高密度脂蛋白(HDL)胆固醇,和甘油三酯,被调查过。
■左甲状腺素治疗后,平均TSH显着降低(62.03vs.2.33±1.95;P<0.0001),甘油三酯(145.57±88.65vs.121.91±59.52,P=0.002),胆固醇(203.90±53.73vs.166.65±40.07,P<0.0001),和血清LDL(123.61±45.03vs.95.99±24.20,P<0.0001),但血清HDL的平均值没有显示任何显着变化(54.18±16.60vs.51.59±18.38,P=0.274)。
■左甲状腺素治疗对明显甲状腺功能减退症患者的血脂有有益作用,因为它降低了血清甘油三酯,总胆固醇,LDL。然而,左旋甲状腺素治疗不会显著改变HDL水平。
UNASSIGNED: Effects of
levothyroxine therapy on the lipid profile of hypothyroid patients lead to decrease in the risk of cardiovascular diseases and mortality.
UNASSIGNED: Overt or subclinical hypothyroid dysfunction has negative effects on lipid metabolism and leads to hypercholesterolemia that in turn increases the risk of cardiovascular diseases and mortality. In this matter, several interventional studies investigated the effects of
levothyroxine therapy on the lipid profile of hypothyroid patients, and conflicting results have been obtained. The current research aims to investigate the effect of
levothyroxine replacement on cholesterol levels in hypothyroid patients.
UNASSIGNED: The present prospective study examined 112 patients (mean age of 43.80 ± 14.36 years) with overt hypothyroidism. To do so, 72.3% of patients were females. Levothyroxine replacement therapy was prescribed for patients, and they were examined monthly to evaluate the effects of therapy on their lipid profiles. After reaching normal thyroid stimulating hormone (TSH), the patients\' laboratory parameters, including TSH, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides, were surveyed.
UNASSIGNED: After Levothyroxine therapy, there was a significant reduction in mean TSH (62.03 vs. 2.33 ± 1.95; P < 0.0001), triglycerides (145.57 ± 88.65 vs. 121.91 ± 59.52, P = 0.002), cholesterol (203.90 ± 53.73 vs. 166.65 ± 40.07, P < 0.0001), and serum LDL (123.61 ± 45.03 vs. 95.99 ± 24.20, P < 0.0001), but the mean value of serum HDL did not show any significant change (54.18 ± 16.60 vs. 51.59 ± 18.38, P = 0.274).
UNASSIGNED: Levothyroxine therapy has beneficial effects on lipid profile in patients with overt hypothyroidism because it decreases serum triglyceride, total cholesterol, and LDL. However,
levothyroxine therapy does not significantly change HDL levels.