Die S2k‐Leitlinie der Hidradenitis suppurativa/Acne inversa (HS/AI) soll eine akzeptierte Entscheidungshilfe für die Auswahl/Durchführung einer geeigneten/suffizienten Therapie liefern. Hidradenitis suppurativa/Acne inversa ist eine chronisch‐rezidivierende, entzündliche, potenziell mutilierende Hauterkrankung des terminalen Haartalgdrüsenapparats, mit schmerzhaften, entzündlichen Läsionen in den apokrinen drüsenreichen Körperregionen. Ihre Punktprävalenz in Deutschland ist 0,3%, sie wird mit einer Verspätung von 10,0 ± 9,6 Jahren diagnostiziert. Abnormale Differenzierung der Keratinozyten des Haartalgdrüsenapparats und eine begleitende Entzündung bilden die zentrale pathogenetische Grundlage. Primäre HS/AI‐Läsionen sind entzündliche Knoten, Abszesse und drainierende Tunnel. Rezidive in den letzten 6 Monaten mit mindestens zwei Läsionen an den Prädilektionsstellen verweisen auf eine HS/AI mit einer 97‐prozentigen Genauigkeit. HS/AI‐Patienten leiden an einer deutlichen Einschränkung der Lebensqualität. Zur korrekten Therapieentscheidung sollen Klassifikation und Aktivitätsbewertung mit einem validierten Instrument erfolgen, wie dem International Hidradenitis Suppurativa Severity Scoring System (IHS4). Hidradenitis suppurativa/Acne inversa wird nach der Ausprägung der nachweisbaren Entzündung in zwei Formen eingeteilt: aktive, entzündliche (milde, mittelschwere und schwere nach IHS4) und vorwiegend inaktive, nicht entzündliche (Hurley‐Grad‐I, ‐II und ‐III) HS/AI. Orale Tetrazykline oder eine 5‐tägige intravenöse Therapie mit Clindamycin sind mit der Effektivität von Clindamycin/Rifampicin vergleichbar. Subkutan applizierbares Adalimumab, Secukinumab und Bimekizumab sind für die Therapie der HS/AI zugelassen. Für die vorwiegend nicht entzündliche Erkrankungsform stehen verschiedene operative Verfahren zur Verfügung. Medikamentöse/chirurgische Kombinationen gelten als ganzheitliches Therapieverfahren.

Functional (Nonorganic) Enuresis and Daytime Urinary Incontinence in Children and Adolescents: Clinical Guideline for Assessment and Treatment Abstract: Objective: Enuresis and daytime urinary incontinence are common disorders in children and adolescents and are associated with incapacitation and a high rate of comorbid psychological disorders. This interdisciplinary guideline summarizes the current state of knowledge regarding somatic and psychiatric assessment and treatment. We formulate consensus-based, practical recommendations. Methods: The members of this guideline commission consisted of 18 professional associations. The guideline results from current literature searches, several online surveys, and consensus conferences based on standard procedures. Results: According to the International Children\'s Continence Society (ICCS), there are four different subtypes of nocturnal enuresis and nine subtypes of daytime urinary incontinence. Organic factors first have to be excluded. Clinical and noninvasive assessment is sufficient in most cases. Standard urotherapy is the mainstay of treatment. If indicated, one can add specific urotherapy and pharmacotherapy. Medication can be useful, especially in enuresis and urge incontinence. Psychological and somatic comorbid disorders must also be addressed. Conclusions: The recommendations of this guideline were passed with a high consensus. Interdisciplinary cooperation is especially important, as somatic factors and comorbid psychological disorders and symptoms need to be considered. More research is required especially regarding functional (nonorganic) daytime urinary incontinence.
Zusammenfassung: Hintergrund: Enuresis und Harninkontinenz tags sind häufige Störungen des Kindesalters, die mit einer hohen Beeinträchtigung und komorbiden psychischen Störungen einhergehen können. Das Ziel dieser interdisziplinären Leitlinie ist es, den aktuellen Stand zur Diagnostik und Therapie dieser Störungen aus somatischer und psychiatrischer Sicht zusammenzufassen und praxisorientierte Empfehlungen zu formulieren. Methoden: Die Leitliniengruppe setzte sich aus 18 Fachgesellschaften zusammen. Die Leitlinie wurde auf der Basis aktueller Literaturrecherchen in mehreren online erfolgten Abstimmungen und Konsensuskonferenzen nach den Regeln der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e. V. (AWMF) verabschiedet. Ergebnisse: Nach der International Children’s Continence Society (ICCS) können vier Subformen der Enuresis (nocturna) und neun der funktionellen Harninkontinenz tags unterschieden werden. Organische Faktoren müssen ausgeschlossen werden. Eine klinische und nicht-invasive Diagnostik ist in den meisten Fällen ausreichend. Eine Standard-Urotherapie stellt die Grundlage der Behandlung dar. Sie kann durch eine spezifische Urotherapie ergänzt werden. Eine Pharmakotherapie kann vor allem bei der Enuresis und Dranginkontinenz sinnvoll sein. Komorbide psychische und somatische Störungen müssen berücksichtigt werden. Schlussfolgerungen: Im Konsensusverfahren konnten alle Empfehlungen mit hoher Zustimmung verabschiedet werden. Eine interdisziplinäre Zusammenarbeit ist von hoher Bedeutung, da somatische Faktoren und komorbide psychische Störungen und Symptome berücksichtigt werden müssen. Forschungsbedarf besteht vor allem bei der funktionellen Harninkontinenz tags.

Die Lebenszeitprävalenz für Urtikaria, die zu den schweren allergischen Erkrankungen zählt, liegt bei nahezu 20%. Sie schränkt nicht nur die Lebensqualität der Betroffenen ein, sondern die generelle Leistungsfähigkeit in Beruf und Alltag. Die vorliegende Publikation ist der erste Abschnitt der Leitlinie Urtikaria. Dieser Teil der Leitlinie umfasst deren Klassifikation und Diagnostik unter Einbeziehung der wesentlichen Fortschritte in der Erforschung ihrer Ursachen, auslösenden Faktoren und Pathomechanismen. Zudem befasst sie sich mit Strategien zur ökonomischen Diagnostik der verschiedenen Unterformen der Urtikaria. Dies ist entscheidend für eine individuelle, patientenorientierte Therapie, die im zweiten Teil behandelt wird. Diese deutschsprachige Leitlinie wurde auf der Basis der internationalen englischsprachigen S3-Leitlinie unter besonderer Berücksichtigung der medizinischen Gegebenheiten im deutschsprachigen Raum entsprechend den Kriterien der AWMF erstellt. Die Leitlinie beschreibt in diesem Abschnitt die Klassifikation der Urtikaria, wobei spontan auftretende Quaddeln und Schwellungen von Urtikariaformen mit induzierbaren Symptomen abgegrenzt werden. Urtikaria wird als plötzlich auftretende Quaddeln, Schwellungen oder beides definiert, ist dabei aber abzugrenzen von Zuständen bei denen Quaddeln als kurzfristiges Symptom auftreten, wie zum Beispiel bei der Anaphylaxie. Die Diagnostik stützt sich auf (eingeschränkte) Laboruntersuchungen, aber insbesondere auch die Anamnese. Darüber hinaus stehen validierte Instrumente zur Verfügung, die den Schweregrad, die Aktivität und den Verlauf erfassen.

Functional Constipation and Nonretentive Fecal Incontinence in Children and Adolescents: Clinical Guideline for Assessment and Treatment Abstract. Objective: Constipation and fecal incontinence are common disorders in children and adolescents and are associated with incapacitation and a high rate of comorbid psychological disorders. Functional constipation and nonretentive fecal incontinence can be differentiated according to the current Rome-IV classification systems. This interdisciplinary guideline aims to summarize the current state of knowledge regarding somatic and psychiatric assessment and treatment. It formulates consensus-based, practical recommendations. Methods: The members of the Guideline Commission consisted of 11 professional associations and a parental organization. The guideline was based on current literature searches, several online surveys, and consensus conferences based on standard procedures. Results: Functional constipation is much more common than nonretentive fecal incontinence. Constipation requires a detailed medical assessment to exclude somatic causes, especially in young children. Red flags are useful indicators of organic causes to be considered. Most cases of constipation are functional (approximately 95 %). Counseling, toilet training, disimpaction, and long-term oral laxatives, combined with cognitive-behavioral interventions, are most effective. The assessment and treatment of nonretentive fecal incontinence are similar. The rate of somatic factors is much lower (approximately 1 %). Laxatives can worsen outcomes and should be avoided. Comorbid psychological disorders are common (approximately 30 % to 50 %). They should be assessed and treated additionally according to evidence-based guidelines. Conclusions: The recommendations of this guideline were approved with a high consensus. Interdisciplinary cooperation is especially important, as somatic factors and comorbid psychological disorders and symptoms need to be considered. More research is required, especially regarding nonretentive fecal incontinence.
Zusammenfassung. Hintergrund: Obstipation und Stuhlinkontinenz gehören zu den häufigsten Störungen des Kindesalters, die mit einer hohen Beeinträchtigung und komorbiden psychischen Störungen einhergehen können. Nach der neuen Rome-IV-Klassifikation wird zwischen einer funktionellen Obstipation und einer nicht-retentiven Stuhlinkontinenz unterschieden. Das Ziel dieser interdisziplinären Leitlinie ist es, den aktuellen Stand zur Diagnostik und Therapie dieser Störungen aus somatischer und psychiatrischer Sicht zusammenzufassen und praxisorientierte Empfehlungen zu formulieren. Methoden: Die Leitliniengruppe setzte sich aus 11 Fachgesellschaften und einer Elterngruppe zusammen. Die Leitlinie wurde auf der Basis aktueller Literaturrecherchen in mehreren Onlineabstimmungen und Konsensuskonferenzen nach den Regeln der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e. V. (AWMF) verabschiedet. Ergebnisse: Die funktionelle Obstipation ist sehr viel häufiger als die nicht-retentive Stuhlinkontinenz. Die Obstipation erfordert ein sorgfältiges medizinisches Vorgehen, um somatische Ursachen auszuschließen, gerade bei jungen Kindern. Dazu dienen somatische Warnzeichen, die besonders berücksichtigt werden müssen. Die meisten Fälle der Obstipation sind funktionell (ca. 95 %). Beratung, Toilettentraining, Desimpaktion und langfristige orale Laxanzien, kombiniert mit verhaltenstherapeutischen Maßnahmen, sind am wirkungsvollsten. Die Diagnostik und Therapie der nicht-retentiven Stuhlinkontinenz ist ähnlich. Die Rate von somatischen Ursachen ist niedriger. Laxanzien können allerdings die Symptomatik verschlechtern und sollten vermieden werden. Komorbide psychische Störungen sind häufig (ca. 30–50 % der Fälle). Sie sollen erfasst und zusätzlich leitliniengerecht behandelt werden. Schlussfolgerungen: Im Konsensusverfahren konnten mit hoher Zustimmung wichtige Empfehlungen verabschiedet werden. Eine interdisziplinäre Zusammenarbeit ist von hoher Bedeutung, da somatische Faktoren und komorbide psychische Störungen und Symptome berücksichtigt werden müssen. Forschungsbedarf besteht vor allem bei der nicht-retentiven Stuhlinkontinenz.

BACKGROUND: Delphi techniques are conducted across different subfields in the health sciences. The reporting practices of studies using Delphi techniques vary, and current reporting guidelines for Delphi techniques focus on individual subfields of the health sciences or on different aspects of research and are therefore of limited applicability. The aim of this article was to identify similarities, differences, and possible shortcomings of existing Delphi reporting guidelines and to draft an initial proposal for a comprehensively applicable reporting guideline.
METHODS: A systematic literature search for reporting guidelines on Delphi studies was performed in existing data resources based on databases in the health sciences (Scopus, MEDLINE, CINAHL, Epistemonikos) including publications from 2016 to 2021. In June 2021, we conducted an additional search in PubMed and included further studies by contacting experts of the scientific Delphi expert network (DeWiss). Title and abstract screening of articles was performed, followed by a full-text screening of the articles included. We qualitatively and quantitatively evaluated, compared and contrasted the reporting guidelines identified using content analysis and discussed the results among the members of the Delphi expert network.
RESULTS: We retrieved ten health science articles with reporting guidelines for Delphi studies. In analyzing them, we identified nine main categories (Justification, Expert panel, Questionnaire, Survey design, Process regulation, Analyses, Results, Discussion, Methods reflection & Ethics). The current reporting guidelines vary significantly, with only the aspect of consensus appearing in all of them. Frequency distributions show that most of the subcategories are only addressed in individual articles (e.g., meeting of participants, proceeding with the survey method, transfer of the results, validation, prevention of bias) and that epistemological foundations of the Delphi technique are rarely mentioned or reflected on. We drafted an initial proposal for Delphi reporting guidelines for the health science sector.
CONCLUSIONS: A well-justified position concerning epistemological foundations of Delphi studies is necessary to make the quality of the process assessable and, along with the reporting of the process, to classify and compare study results. This will increase the acceptance of both the method in the health science sector and the results in medical practice. A Delphi reporting guideline must, above all, take into account the diversity of variants, subfield-related objectives and application areas, and their modifications of the Delphi technique in order to be comprehensively applicable in the health sciences.
CONCLUSIONS: The results of our methodological review do not provide a final reporting guideline. The newly developed proposal is intended to encourage discussion and agreement in further analyses.

BACKGROUND: Recommendations of evidence- and formally consensus-based clinical practice guidelines (CPGs) represent a valuable source of quality indicators (QIs). Nevertheless, a standardized methodological procedure for developing QIs in the context of CPGs does not yet exist in Germany for all CPGs. For this reason, a methodological standard for the guideline-based development of QIs (QI Standard) was developed based on a structured consensus process involving multiple key stakeholders.
METHODS: The proposed content of the QI Standard was derived from evidence, drawing upon results of reviews and qualitative studies, and considered German manuals for guideline-based QI development of two guideline programs. A multi-perspective consensus panel, broadly representing key stakeholders from the German healthcare system with expertise in CPGs and/or quality management, was nominated to vote on recommendations for guideline-based development of QIs. The iterative, structured consensus process included a two-stage online survey based on the Delphi method (\"preliminary voting\") and a moderated final stakeholder conference where all those recommendations were definitely included in the QI Standard that received approval of more than 75 % (consensus criterion) of the consensus panel.
RESULTS: Based on the agreed QI Standard, the QI development process starts with a criteria-based selection of \"potential\" QIs which - in case of adoption - are published in CPGs as \"preliminary\" QIs and can achieve the status \"final\" after successful testing. The QI Standard is composed of a total of 30 recommendations, which are allocated to six areas: A) preparatory work steps for the guideline-based recommendation of QIs, B) QI development group and cooperation with the CPG group, C) development of potential QIs, D) critical appraisal of potential QIs, E) formal adoption and publication as well as F) piloting/testing of preliminary QIs and conversion into final QIs.
CONCLUSIONS: Before the QI Standard can be recommended for implementation in future CPGs, it should have been successfully tested in selected German CPG projects. In addition to methodological requirements for the QI development, it must be ensured that guideline groups have adequate resources for the implementation of the QI Standard.
CONCLUSIONS: By using the QI Standard, scientifically sound and healthcare-relevant QIs can be expected.

Nutritional management in malnourished children and adolescents in home care - recommendations from a setting-specific evidence-based guideline Abstract. Background: Malnutrition in children is an underestimated phenomenon that is frequently unrecognized and therefore not adequately treated. If the treatment is inadequate, malnutrition can lead to a variety of negative consequences for the childrens\' development. Corresponding guidelines for malnutrition for pediatric nursing in home care settings are lacking. Aim: The aim of this paper is to present the nutritional management of malnourished children, which was elaborated in the course of developing a setting-specific guideline for pediatric home care. Methods: The developed guideline is based on the approach described by the Scientific Medical Societies Working Group. This approach encompasses a) forming a group of experts, b) defining clinical questions, c) searching the literature, d) evaluating and synthesizing the literature, and d) formulating recommendations. Parents were included to rate the relevance of the recommendations. Results: The nutrition management involves a detailed nutritional assessment, subsequent oral, enteral or parenteral interventions, weight monitoring and a re-assessment of the child\'s nutritional status. Nurses, as well as parents/legal guardians, play essential roles in planning and implementing nutrition management in the home care setting. Conclusions: The use of the guideline may contribute to the early detection of causes for malnutrition and adequate multidisciplinary treatment of children with suspected or identified malnutrition in the home care setting.
Zusammenfassung. Hintergrund: Mangelernährung bei Kindern ist ein unterschätztes und häufig nicht erkanntes Phänomen. Bei unzureichender Behandlung kann Mangelernährung eine Vielzahl von negativen Folgen für die Entwicklung von Kindern haben. Gegenwärtig liegt für die häusliche Kinderkrankenpflege keine Leitlinie zu Mangelernährung vor. Ziel: Das Ziel des vorliegenden Beitrags ist es, das Ernährungsmanagement von mangelernährten Kindern im Sinne der Unterernährung darzustellen, welches im Zuge der Entwicklung einer settingspezifischen Leitlinie für die häusliche Kinderkrankenpflege erarbeitet wurde. Methodik: Die entwickelte Leitlinie basiert auf der laut Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften beschriebenen Vorgehensweise: Bildung einer Arbeitsgruppe aus Expert_innen, Definition klinischer Fragen, Literaturrecherche, -bewertung und -synthese und Formulierung von Empfehlungen. Für die inhaltliche Relevanz der Empfehlungen wurden zusätzlich Eltern miteinbezogen. Ergebnisse: Das Ernährungsmanagement umfasst a) ein Ernährungs-Assessment, b) darauffolgende orale, enterale oder parenterale Maßnahmen, c) Gewichts-Monitoring sowie d) ein Re-Assessment der Ernährungssituation des Kindes. Pflegepersonen und Bezugspersonen übernehmen im Rahmen dessen unterschiedliche Tätigkeiten. Schlussfolgerung: Die Verwendung der Leitlinie kann bei Kindern mit einem Verdacht oder einer festgestellten Mangelernährung in der häuslichen Umgebung zu einer frühzeitigen Erkennung der Ursachen und einer adäquaten multidisziplinären Behandlung beitragen.

BACKGROUND: Evidence-based and formally consensus-based clinical practice guidelines (S3-CPGs) are a valuable source for the development of quality indicators (QIs) in Germany. While deriving QIs from guideline recommendations is a mandatory part of the development of S3-CPGs within the National Program for Disease Management Guidelines (DMGP) and the German Guideline Program in Oncology (GGPO), there is no such obligation in the guideline program of the Association of the Scientific Medical Societies in Germany (AWMF) (MS program). Despite that, several S3-CPGs in the MS program have been published with QIs in the last years while some DMGP and one GGPO S3 guidelines have failed to meet this requirement. From the perspective of the guideline authors of all three mentioned programs, the present qualitative study examined why S3-CPGs do or do not contain QIs and explored the factors perceived by authors as either facilitating or hampering in the QI development process.
METHODS: Semi-structured interviews were conducted with authors of 22 S3-CPGs, 11 of which represented guidelines containing QIs and 11 of which represented guidelines without QIs. Authors of guidelines containing QIs (n=11) were asked about the perceived decisive reasons for formulating QIs and about facilitators and barriers during the QI development process. Authors of guidelines without QIs (n=11) gave reasons for not formulating QIs. Interviews were analyzed using structuring qualitative content analysis.
RESULTS: Within the MS program, not formulating QIs was mainly attributed to the lack of a mandatory requirement and to insufficient funding of guideline projects. Amongst DMGP authors, a low priority of QI development prevailed, which was, for example, due to already existing QIs or to their lacking implementation. In the GGPO guideline examined, not formulating QIs was due to the guideline topic (prevention) - for this topic, there was a lack of suitable evidence and data sources. If QIs were developed, the most important facilitating factor in the development process, across all programs, was the methodological support provided by the guideline program. Important hampering factors included the additional time required for QI development and concerns regarding the implementation of many potential QIs, especially due to a lack of data availability.
CONCLUSIONS: For regular development of QIs within S3-CPG projects, the incorporation of such a requirement in the guideline program is a necessary, but not a sufficient, condition. Other pivotal factors include systematic methodological support, adequate financial and staff resources and the perceived meaningfulness and relevance of guideline-based QI development, measured in terms of the actual implementation of already existing QIs.
CONCLUSIONS: The study reveals starting points for measures to strengthen the consideration of QI development in German S3-CPG projects, especially within the MS program. Without substantial structural changes, especially of the resources of guideline groups, and without an overall concept covering the entire process from QI development to QI implementation, guideline-based QI development will remain heavily dependent on the (self-)motivation of guideline groups.

BACKGROUND: Evidence-based and formally consensus-based clinical practice guidelines (CPGs) offer potential for the development of quality indicators (QIs). Although QIs are recommended as part of some CPGs, there is no accepted gold standard for the specific development process of guideline-based QIs. The purpose of this review, which is embedded in a mixed-methods research project, was to analyze the current state of methodological approaches for QI development in German CPGs to derive insights for the development of a national evidence-guided and consensus-based standard for guideline-based development of QIs.
METHODS: In order to identify valid CPGs containing recommendations for QIs, a search was carried out (July 31, 2016) via the guideline database of the German Association of the Scientific Medical Societies (AWMF). Based on a stratified random sample per guideline program (guidelines published by medical societies, National Program for Disease Management Guidelines (DMG), and the German Guideline Program in Oncology [GGPO]), 11 CPGs were selected. With regard to QIs, the specific development methodology, indications on their psychometric properties and how the quality of care should be examined by recommended QIs were extracted and compared by using the guideline documents.
RESULTS: In 35 of the 109 (16/85 medical societies, 4/8 DMG, 15/16 GGPO) (32 %) valid CPGs, a total of 372 QIs were recommended. Based on 11 randomly selected guidelines (5 published by medical societies, 1 DMG, 5 GGPO; a total of 109 QIs), the QI development methodology was inconsistent in all five medical societies guidelines (including QI presentation, usage and selection of guideline recommendations for QI derivation) compared to DMG and GGPO. Based on all 109 QIs, 2 (2 %) were presented as a quantitative measure with a reference range, and quality objectives were formulated for 17 (16 %). There was no guideline explicitly reporting about the results of a pilot study or data-based analysis of the psychometric properties of the recommended QIs. The GGPO guideline documents were the only ones providing information on the assessment of the quality of care based on recommended QIs.
CONCLUSIONS: The usage of the QI manuals of the DMG and GGPO leads to a largely standardized development of guideline-based QIs. In the CPGs of the medical societies - if at all - QIs are developed inconsistently and mostly unsystematically. Due to largely missing reference ranges and quality objectives, the identified QIs cannot yet be used to transparently identify potential quality deficits in health care. This requires results of pilot studies and further development of guideline-based QI.
CONCLUSIONS: A standard for QI development is needed for German guideline authors to seize the opportunity and develop clinically relevant, widely accepted and evidence-based QIs in the guideline development process. In addition, it must be ensured that appropriate structures are used or set up in order to be able to apply the recommended QIs in the German healthcare system.

BACKGROUND: The development of high-quality clinical practice guidelines is laborious and time-consuming. New methods have become available to streamline this process. However, the awareness of these methods should be improved.
METHODS: Selective literature search in PubMed/MEDLINE und Embase.
RESULTS: Simple tools such as surveys or voting systems can facilitate the organization, planning and communication. Adequate methods should be used to prioritize all potential questions that should be addressed in the guideline. Published or ongoing international guidelines and systematic reviews can be used meaningfully for the planned guideline. In the case of guideline updates, it should be determined whether all parts of the guideline require an update of the evidence. The need for an update should be investigated. The concept of living guidelines has the biggest potential to provide gains in efficiency. Living guidelines are continuously updated based on new evidence instead of being regularly updated at a predefined time.
CONCLUSIONS: New methods allowing for more efficient guideline production have been developed and, in part, already been introduced. Before starting with the production of a guideline (or its update), the potential advantages and disadvantages/risks of the corresponding methods should be balanced.