■酒渣鼻发病率高,显著影响生活质量,缺乏足够的诊断技术。本研究旨在探讨激光散斑对比成像(LSCI)用于测量酒渣鼻患者面部血液灌注的可行性,并确定与不同酒渣鼻亚型相关的各个面部区域之间的血流差异。
■从2023年6月到12月,招募了45名患者,排除了9个,留下36名受试者:12名红斑凝集性酒渣鼻(ETR),12伴丘疹性酒渣鼻(PPR),和12个健康对照。ThinkView多光谱成像分析仪通过整个面部和五个面部区域的灰色读数值评估炎症:额头,鼻子,脸颊,还有下巴.LSCI测量并分析了相同区域的血液灌注。血浆生物标志物白细胞介素-6(IL-6),IL-1β,并对不同组的肿瘤坏死因子-α(TNF-α)进行检测。
■与对照组相比,ETR和PPR组均显示平均血液灌注和面部炎症强度的灰度值增加,具有统计学上的显著差异。ETR和PPR组的平均血液灌注显示前额值增加,脸颊,鼻子,与对照组相比,ETR和PPR之间的脸颊值具有统计学差异。ETR组的面部炎症强度显示额头和脸颊的值增加,PPR组显示前额的灰度值增加,脸颊,鼻子,和下巴与对照组相比,和脸颊的值,鼻子,和下巴在ETR和PPR之间有统计学差异。血浆生物标志物IL-6,IL-1β,与对照组相比,ETR和PPR组的TNF-α显着升高。
■LSCI是一个有价值的,用于评估酒渣鼻血流动力学的非侵入性工具,为临床研究提供数据基础。不同的酒渣鼻亚型表现出不同的病变分布和血流模式,ETR和PPR都可能影响所有面部区域,尤其是ETR的脸颊和前额,鼻子,和下巴在PPR。
UNASSIGNED: Rosacea has a high incidence, significantly impacts quality of life, and lacks sufficient diagnostic techniques. This study aimed to investigate the feasibility of laser speckle contrast imaging (LSCI) for measuring facial blood perfusion in patients with rosacea and to identify differences in blood flow among various facial regions associated with different rosacea subtypes.
UNASSIGNED: From June to December 2023, 45 patients were recruited, with 9 excluded, leaving 36 subjects: 12 with erythematotelangiectatic rosacea (ETR), 12 with papulopustular rosacea (PPR), and 12 healthy controls. The Think View multispectral imaging analyzer assessed inflammation via gray reading values across the full face and five facial areas: forehead, nose, cheeks, and chin. LSCI measured and analyzed blood perfusion in the same areas. Plasma biomarkers interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α) were tested in different groups.
UNASSIGNED: Both ETR and PPR groups showed increased average blood perfusion and facial inflammation intensity by gray values compared to controls, with statistically significant differences. Average blood perfusion of ETR and PPR groups showed increased values in the forehead, cheeks, and nose, compared to controls, and the values in the cheeks were statistically different between ETR and PPR. The facial inflammation intensity of the ETR group showed increased values in the forehead and cheeks, and the PPR group showed increased gray values in the forehead, cheeks, nose, and chin compared to controls, and the values for the cheeks, nose, and chin were statistically significantly different between ETR and PPR. Plasma biomarkers IL-6, IL-1β, and TNF-α were significantly elevated in both ETR and PPR groups compared to controls.
UNASSIGNED: LSCI is a valuable, non-invasive tool for assessing blood flow dynamics in rosacea, providing a data foundation for clinical research. Different rosacea subtypes exhibit distinct lesion distribution and blood flow patterns, and both ETR and PPR could affect all facial areas, particularly the cheeks in ETR and the forehead, nose, and chin in PPR.