Labor Stage, First

  • 文章类型: Journal Article
    背景:弗里德曼的标准,大约50年前发展起来的,可能不再符合当今产科人群的需求和当前的妊娠管理实践。本研究旨在分析中国当代劳动模式并估计劳动持续时间,重点关注中国自发分娩产妇的第一阶段分娩数据。
    方法:这项回顾性观察研究利用了长沙某三甲医院的电子病历数据,湖南。在总共2689名产妇中,排除了多次妊娠,早产,学期结束后,或者死产,剖宫产,非顶点表示,和新生儿重症监护病房入院。平均劳动力曲线是使用重复测量分析通过平价构建的,劳动持续时间是通过间隔审查回归估计的,入院时宫颈扩张分层。我们进行了一项分析以评估催产素增强和羊膜切开术对分娩进展的影响,并对结局复杂的女性进行了敏感性分析。
    结果:未产妇女从3到4厘米宫颈扩张需要超过180分钟,从5到6厘米的持续时间超过145分钟。多产妇女的分娩时间比未产妇女短。在未产中5厘米后观察到分娩加速,但是在平均劳动力曲线中没有明显的拐点。在劳动的第二阶段,未产的第95百分位数,有或没有硬膜外镇痛,是142分钟和127分钟,分别。
    结论:这些发现为重新评估当代产科人群的分娩和分娩过程提供了有价值的见解,包括目前的中国产科实践。
    BACKGROUND: Friedman\'s standards, developed almost 50 years ago, may no longer align with the needs of today\'s obstetric population and current pregnancy management practices. This study aims to analyze contemporary labor patterns and estimate labor duration in China, focusing on first-stage labor data from Chinese parturients with a spontaneous onset of labor.
    METHODS: This retrospective observational study utilized data from electronic medical records of a tertiary hospital in Changsha, Hunan. Out of a total of 2,689 parturients, exclusions were made for multiple gestations, preterm, post-term, or stillbirth, cesarean delivery, non-vertex presentation, and neonatal intensive care unit admission. Average labor curves were constructed by parity using repeated-measure analysis, and labor duration was estimated through interval-censored regression, stratified by cervical dilation at admission. We performed an analysis to assess the impact of oxytocin augmentation and amniotomy on labor progression and conducted a sensitivity analysis using women with complicated outcomes.
    RESULTS: Nulliparous women take over 180 minutes for cervical dilation from 3 to 4 cm, and the duration from 5 to 6 cm exceeds 145 minutes. Multiparous women experience shorter labor durations than nulliparous. Labor acceleration is observed after 5 cm in nulliparous, but no distinct inflection point is evident in the average labor curve. In the second stage of labor, the 95th percentile for nulliparous, with and without epidural analgesia, is 142 minutes and 127 minutes, respectively.
    CONCLUSIONS: These findings provide valuable insights for the reassessment of labor and delivery processes in contemporary obstetric populations, including current Chinese obstetric practice.
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  • 文章类型: Journal Article
    劳动护理必须平衡父母的愿望与对意外灾难的警惕。“现场助产士主导的初级保健分娩室”为这一点提供了便利。世界卫生组织已经用“劳动护理指南”取代了传统的Partograph。博茨瓦纳的一个实施项目包括记忆COPE:伴侣,口服液,缓解疼痛并消除仰卧位。坦桑尼亚的帕托-马项目使用了指导方针,培训和支持,以改善分娩结果。我们列出了最近证据支持的劳动实践,并强调新的发展。巨大胎儿增加风险,但错误诊断会增加剖腹产。产程梗阻是一个复杂的临床诊断,而且很难预测.对于肩难产,优先考虑后肩的分娩,如果需要,通过后腋下吊带牵引促进。“延长球囊引产”与两个或三个Foley导管并排,可以降低与子宫兴奋剂相关的风险。床旁超声可以帮助诊断头部畸形和畸形。
    Labour care must balance aspirations of parents with vigilance for unanticipated calamities. The \'on-site midwife-led primary care birth unit\' facilitates this. The World Health Organization have replaced the traditional partograph with the \'Labour Care Guide\'. An implementation project in Botswana included the mnemonic COPE: Companion, Oral fluids, Pain relief and Eliminate the supine position. The Parto-Ma project in Tanzania used guidelines, training and support to improve childbirth outcomes. We list labour practices supported by recent evidence, and highlight new developments. Foetal macrosomia increases risk but mistaken diagnosis increases caesarean births. Obstructed labour is a complex clinical diagnosis, and is difficult to predict. For shoulder dystocia prioritise delivery of the posterior shoulder, facilitated if needed by posterior axilla sling traction. \'Extended balloon labour induction\' with two or three Foley catheters side by side, may reduce risks associated with uterine stimulants. Bedside ultrasound may facilitate the diagnosis of cephalic malpositions and malpresentations.
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  • 文章类型: Journal Article
    目的:经产妇女的产程较短。然而,没有关于同一产妇连续分娩的分娩时间差异的个性化数据.
    方法:我们从2004年到2021年在苏黎世的大学医院进行了一项回顾性数据分析,并纳入了头位单胎婴儿阴道分娩2次或以上的所有妇女,妊娠22至42周。描述性统计是使用SPSS25.0版(IBM,SPSSInc.,美国)。主要终点是同一产妇连续分娩的分娩阶段持续时间之间的比率。
    结果:共有3344名妇女,有7066名分娩(2601名第一[P0],2987s[P1],1176第三[P2],和302第四[P3])被包括在内。P1和P0之间的主动第一产程持续时间的比率为0.49(95%CI0.47-0.51,p<0.001),这意味着主动第一产程缩短了51%。与P0相比,P1的第二产程为0.26(95%CI0.24-0.27,p<0.001),缩短了74%。与P0相比,第一个孩子的出生体重较高导致P1的第二阶段分娩持续时间减少更大(p=0.003)。神经轴麻醉是延长产程的独立危险因素,不考虑奇偶校验(p<0.001)。同一妇女出生的孩子之间的出生体重和新生儿的HC没有显着差异。然而,第一个孩子出生体重的增加显着增加了P0和P1之间的第二阶段分娩率(p=0.003)。
    结论:直到第三次交付,分娩时间随着同一位产妇的连续分娩而减少。应鼓励对多胎妇女的预期分娩时间进行个性化评估。
    OBJECTIVE: Labor is shorter in multiparous women. However, there are no individualized data on differences in duration of labor for consecutive deliveries in the same parturient.
    METHODS: We conducted a retrospective data analysis from 2004 to 2021 at the University Hospital of Zurich and included all women with 2 or more vaginal deliveries of a singleton child in cephalic position, between 22 and 42 weeks of gestation. Descriptive statistics were performed with SPSS version 25.0 (IBM, SPSS Inc., USA). The primary endpoint was the ratio between durations of labor stages in consecutive deliveries of the same parturient.
    RESULTS: A total of 3344 women with 7066 births (2601 first [P0], 2987 s [P1], 1176 third [P2], and 302 fourth [P3]) were included. The ratio of duration of the active first stage of labor between P1 and P0 was 0.49 (95% CI 0.47-0.51, p < 0.001) meaning that the active first stage of labor was 51% shorter. The second stage of labor with a ratio of 0.26 (95% CI 0.24-0.27, p < 0.001) was 74% shorter in P1 compared to P0. Higher birthweight of the first child led to an even greater decrease in duration of the second stage of labor in P1 compared to P0 (p = 0.003). Neuraxial anesthesia was an independent risk factor for a longer duration of labor, irrespective of parity (p < 0.001). Birthweight and HC of the neonates did not significantly differ between the children born by the same women. However, higher birthweight in of the first child significantly augmented the rate of second stage of labor between P0 and P1 (p = 0.003).
    CONCLUSIONS: Up to the third delivery, duration of labor decreased with each consecutive delivery of the same parturient. An individualized assessment of the expected duration of labor in multiparous women should be encouraged.
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  • 文章类型: Journal Article
    目的:确定Carousel模拟器在产科检查医学教育中的可靠性。孕妇宫颈扩张检查培训使患者面临额外的不舒服和健康风险程序,黄金标准,并且不能客观地评估医学生的能力。
    方法:我们研究了产科实习医学生培训的可靠性。参与的学生被分配在模拟器上进行宫颈扩张的数字评估。使用旋转木马模拟器进行12次连续的随机盲预定宫颈扩张检查。记录并分析了精确答案和在±1cm内的确定性答案。考虑到不正确或离群的答案,距离扩张≥2厘米。构建了每个厘米膨胀模拟的色散图。
    结果:66名产科医生参加了,进行396次检查。因此,我们在模拟评估中观察到49个异常值(12.37%)。根据分析,我们没有观察到扩张1~4cm的异常值;扩张7~9cm的异常值测量指数较高.我们没有将任何膨胀模拟色散图视为零相关性。在膨胀1至6cm和膨胀10cm中观察到强相关性。扩张7、8和9cm显示弱相关性。
    结论:旋转木马模拟器模型是学生学习的可靠方法。模拟器是一种必不可少的研究工具,能够减少由于体内数字阴道检查的过多和重复次数而造成的尴尬和可能的伤害。提出了改进模拟器装置和方法的新研究,主要是估计在体内练习之前需要的足够的重复和训练。
    OBJECTIVE: To determine the reliability of the Carousel simulator in medical education for obstetric examinations. Cervical dilation examination training in pregnant women exposes patients to additional uncomfortable and health-risk procedures, a gold standard, and does not objectively evaluate the medical student\'s competence.
    METHODS: We studied the reliability of training internship medical students in obstetrics. Participating students were assigned to take the examination of digital assessment of the cervical dilation on the simulator. Classes performed 12 consecutive randomly blind predetermined cervical dilation examinations using the Carousel simulator. The exact answer and the answer with certainty within ±1 cm were registered and analyzed. Incorrect or outlier answers were considered with a cutoff of ≥2 cm from the dilation. A dispersion graph for each centimeter of dilation simulation was constructed.
    RESULTS: Sixty-six medical obstetricians took part, performing 396 examinations. Thus, we observed 49 outliers (12.37%) in simulated assessments. According to the analysis, we did not observe outliers from dilation 1 to 4 cm; dilation 7 to 9 cm had a higher index of outlier measurements. We did not consider any dilation simulation dispersion graphic as a null correlation. A strong correlation was seen in the dilation 1 to 6 cm and the dilation 10 cm. The dilations 7, 8, and 9 cm showed a weak correlation.
    CONCLUSIONS: The Carousel simulator model is a reliable method for student learning. The simulator is an essential study tool capable of reducing the embarrassment and possible harm caused by the excessive and repetitive number of in vivo digital vaginal examinations. Novel studies are proposed to improve the simulator device and method, mainly to estimate the adequate repetitions and training needed before in vivo practice.
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  • 文章类型: Journal Article
    研究无创因素和预测维持妊娠,以及那些将这些因素与侵入性羊水标志物在预测抢救环扎后妊娠维持中的有用性进行比较的人,缺乏。因此,这项研究旨在确定C反应蛋白(CRP)水平,白细胞(WBC)计数,中性粒细胞绝对计数(ANC),和母亲血液中的血小板与淋巴细胞比率(PLR),它们是无创的和容易获得的临床标志物,可以预测宫颈功能不全(CI)患者抢救环扎术后的妊娠维持情况。回顾性评估了142例接受CI抢救环扎的单胎孕妇(15-28周)。羊水白细胞介素(IL)-6浓度;CRP水平,白细胞计数,ANC,母亲外周血中的PLR;并在环扎前评估宫颈扩张程度。主要结果是抢救环扎术后妊娠是否维持>4周。在142名患者中,在107例(75.35%)中观察到紧急环扎后>4周的延长妊娠,而35人(24.65%)在4周内分娩。这项研究表明,诊断时宫颈扩张的程度;白细胞计数,ANC,成功组和失败组孕妇外周血CRP水平和羊水IL-6浓度差异有统计学意义(P均<0.05)。羊水IL-6浓度的曲线下面积(AUC)为0.795,用于预测抢救环扎后4周内的自发性早产。此外,CRP水平的AUC,宫颈扩张,白细胞计数,ANC,PLR分别为.795、.703、.695、.682和.625。这些发现表明,术前CRP水平可被认为是与羊水IL-6浓度相当的有用的非侵入性标志物,可用于识别处于抢救环扎后自发性早产高危CI的孕妇。
    Studies on noninvasive factors and predicting the maintenance of pregnancy, and those comparing the usefulness of these factors with invasive amniotic fluid markers in predicting the maintenance of pregnancy following rescue cerclage, are lacking. Therefore, this study aimed to determine whether C-reactive protein (CRP) levels, White blood cell (WBC) count, absolute neutrophil count (ANC), and platelet-to-lymphocyte ratio (PLR) in maternal blood, which are noninvasive and readily available clinical markers, can predict the maintenance of pregnancy following rescue cerclage in patients with cervical insufficiency (CI). A total of 142 singleton pregnant women (15-28 wk) who underwent rescue cerclage for CI were retrospectively evaluated. The interleukin (IL)-6 concentration in the amniotic fluid; CRP levels, WBC count, ANC, and PLR in the maternal peripheral blood; and degree of cervical dilatation were evaluated before cerclage. The primary outcome was whether the pregnancy was maintained for >4 weeks after rescue cerclage. Among the 142 patients, prolonged pregnancy for >4 weeks following emergent cerclage was observed in 107 (75.35%), while 35 (24.65%) gave birth within 4 weeks. This study demonstrated that the degree of cervical dilatation at diagnosis; WBC count, ANC, and CRP levels in the maternal peripheral blood; and IL-6 concentration in the amniotic fluid significantly differed between the successful and failure groups (all P < .05). The area under the curve (AUC) of the amniotic fluid IL-6 concentration was .795 for the prediction of spontaneous preterm birth within 4 weeks after rescue cerclage. Additionally, the AUC of the CRP level, cervical dilatation, WBC count, ANC, and PLR were .795, .703, .695, .682, and .625, respectively. These findings suggest that the preoperative CRP levels can be considered a useful noninvasive marker comparable to amniotic fluid IL-6 concentration for identifying pregnant women with CI at high risk of spontaneous preterm birth following rescue cerclage.
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  • 文章类型: Systematic Review
    目的:进行了系统的范围审查,目的是1)确定和描述说明宫颈扩张随时间变化的产程曲线;2)绘制任何证据,以及用于评估曲线的准确性和有效性的结果;3)确定需要进一步调查的研究领域。
    方法:对截至2023年5月的出版物进行了三步系统的文献检索。我们搜查了Medline,妇幼保健,Embase,科克伦图书馆,认识论,CINAHL,Scopus,和非洲指数医学数据库,用于描述劳动曲线的研究,评估其改善分娩结果的有效性,或评估其作为筛查或诊断工具的准确性。包括原始研究文章和系统综述。我们排除了回顾性调查不良出生结局的研究,以及那些研究镇痛相关干预措施对产程进展的影响的人。评估了研究资格,并使用试点图表表格从纳入的研究中提取数据。这些发现是根据为所包括的研究创建的描述性摘要来呈现的。
    在26,073项潜在符合条件的研究中,共纳入108项研究。七十三项研究描述了劳动力曲线,其中13个中的10个主要基于美国安全劳工联盟。分娩曲线终点为69项研究中宫颈扩张10cm,4项研究中阴道分娩。在26项研究中评估了分娩曲线的准确性,其中1986年以后出版的所有15个来自低收入和中等收入国家。最近缺乏对高收入国家劳动力曲线准确性的研究。在13项研究中评估了劳动曲线的有效性,未能证明任何曲线的优越性。患者报告的健康和福祉是劳动力曲线评估中代表性不足的结果。劳动曲线的有用性仍然是一个争论的问题,因为研究未能证明其准确性或有效性。
    OBJECTIVE: This systematic scoping review was conducted to 1) identify and describe labor curves that illustrate cervical dilatation over time; 2) map any evidence for, as well as outcomes used to evaluate the accuracy and effectiveness of the curves; and 3) identify areas in research that require further investigation.
    METHODS: A three-step systematic literature search was conducted for publications up to May 2023. We searched the Medline, Maternity & Infant Care, Embase, Cochrane Library, Epistemonikos, CINAHL, Scopus, and African Index Medicus databases for studies describing labor curves, assessing their effectiveness in improving birth outcomes, or assessing their accuracy as screening or diagnostic tools. Original research articles and systematic reviews were included. We excluded studies investigating adverse birth outcomes retrospectively, and those investigating the effect of analgesia-related interventions on labor progression. Study eligibility was assessed, and data were extracted from included studies using a piloted charting form. The findings are presented according to descriptive summaries created for the included studies.
    UNASSIGNED: Of 26,073 potentially eligible studies, 108 studies were included. Seventy-three studies described labor curves, of which ten of the thirteen largest were based mainly on the United States Consortium on Safe Labor cohort. Labor curve endpoints were 10 cm cervical dilatation in 69 studies and vaginal birth in 4 studies. Labor curve accuracy was assessed in 26 studies, of which all 15 published after 1986 were from low- and middle-income countries. Recent studies of labor curve accuracy in high-income countries are lacking. The effectiveness of labor curves was assessed in 13 studies, which failed to prove the superiority of any curve. Patient-reported health and well-being is an underrepresented outcome in evaluations of labor curves. The usefulness of labor curves is still a matter of debate, as studies have failed to prove their accuracy or effectiveness.
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  • 文章类型: Journal Article
    分娩的第二阶段从宫颈完全扩张延伸到分娩。在这个阶段,当胎儿被动地通过产道通过时,就会发生先兆部分的下降和旋转。一般来说,在扩张的减速阶段开始下降,因为子宫颈被向上拉动围绕胎儿先兆部分。评估第二阶段劳动正常性的最常见方法是测量其持续时间,但是通过测量胎儿位置随时间的变化,可以更有意义地衡量进展。准确的临床识别和评估胎儿下降模式的差异对于评估第二产程进展和对干预的必要性做出合理的判断是必要的。可以确定第二产程的三个明显的图形异常:长期下降,逮捕血统,和失败的下降。所有的异常都与头盆不相称有很强的关联,但也可能发生在母亲肥胖的情况下,子宫感染,过度镇静,和胎儿错位。必须在其他临床上可识别的事件和观察的背景下解释胎儿下降的进展。这些包括胎儿大小,position,态度,颅骨成型程度和骨盆结构和适应胎儿能力的相关评估,子宫收缩力,和胎儿的健康.催产素输注通常可以解决由抑制因素引起的下降停止或下降失败或长时间下降,如密集的神经轴块。只有在对胎骨盆关系进行彻底评估后发现头盆比例失衡的可能性较低的情况下,才应使用该方法。强迫瓦尔萨尔瓦的价值,眼底压力,常规会阴切开术也受到质疑。它们应该有选择性地使用,并在有指示的地方使用。
    The second stage of labor extends from complete cervical dilatation to delivery. During this stage, descent and rotation of the presenting part occur as the fetus passively negotiates its passage through the birth canal. Generally, descent begins during the deceleration phase of dilatation as the cervix is drawn upward around the fetal presenting part. The most common means of assessing the normality of the second stage of labor is to measure its duration, but progress can be more meaningfully gauged by measuring the change in fetal station as a function of time. Accurate clinical identification and evaluation of differences in patterns of fetal descent are necessary to assess second stage of labor progress and to make reasoned judgments about the need for intervention. Three distinct graphic abnormalities of the second stage of labor can be identified: protracted descent, arrest of descent, and failure of descent. All abnormalities have a strong association with cephalopelvic disproportion but may also occur in the presence of maternal obesity, uterine infection, excessive sedation, and fetal malpositions. Interpretation of the progress of fetal descent must be made in the context of other clinically discernable events and observations. These include fetal size, position, attitude, and degree of cranial molding and related evaluations of pelvic architecture and capacity to accommodate the fetus, uterine contractility, and fetal well-being. Oxytocin infusion can often resolve an arrest or failure of descent or a protracted descent caused by an inhibitory factor, such as a dense neuraxial block. It should be used only if thorough assessment of fetopelvic relationships reveals a low probability of cephalopelvic disproportion. The value of forced Valsalva pushing, fundal pressure, and routine episiotomy has been questioned. They should be used selectively and where indicated.
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  • 文章类型: Journal Article
    目的:评估产程进展的完善的临床实践包括常规腹部触诊和阴道检查(VE)。然而,VE是主观的,可重复性差,女性痛苦。在这项研究中,我们的目的是评估系统地整合经腹和经会阴超声评估胎儿位置的可行性,psAOP,HPD和SCD监测引产(IOL)妇女的分娩进展。我们还旨在确定超声检查是否可以减轻女性在检查期间的疼痛。
    方法:在三个产妇单元中招募妇女进行IOL检查。对100名妊娠37+0至41+6周的女性进行超声评估。进行基线经腹和经会阴联合扫描,包括胎儿生物测定的评估,脐动脉和大脑中动脉多普勒,羊水指数(AFI),胎儿脊柱和枕骨位置,psAOP,火警局,SCD,和宫颈长度。根据方案进行产时扫描而不是VE。参与者被要求在评估期间通过口头给出0-10的疼痛评分(0表示没有疼痛)来表明他们的疼痛水平。通过混合效应模型对重复测量数据进行分析,以确定影响psAOP之间关系的重要因素,火警局,SCD和交付方式。
    结果:223次产时超声扫描,每位参与者的中位数为2次(四分位距(IQR)=1-3),进行了151次评估,每位参与者的中位数为1次(IQR=0-2)。没有不良的胎儿或母体结局。在排除检查期间硬膜外麻醉的患者后,产时扫描的中位疼痛评分为0(IQR=0-1),VE的中位疼痛评分为3(IQR=0-6).剖宫产和硬膜外麻醉与psAOP变化速率较慢显著相关,HPD和SCD。产妇身高,产次和新生儿出生体重不影响超声测量产程进展.
    结论:全面的经腹和经会阴超声评估可以成功地用于评估产程进展,并可以减轻检查过程中的疼痛程度。超声评估可能能够替代分娩期间的一些经腹和VE检查。本文受版权保护。保留所有权利。
    OBJECTIVE: Well-established clinical practice for assessing progress in labor involves routine abdominal palpation and vaginal examination (VE). However, VE is subjective, poorly reproducible and painful for most women. In this study, our aim was to evaluate the feasibility of systematically integrating transabdominal and transperineal ultrasound assessment of fetal position, parasagittal angle of progression (psAOP), head-perineum distance (HPD) and sonographic cervical dilatation (SCD) to monitor the progress of labor in women undergoing induction of labor (IOL). We also aimed to determine if ultrasound can reduce women\'s pain during such examinations.
    METHODS: Women were recruited as they presented for IOL in three maternity units. Ultrasound assessments were performed in 100 women between 37 + 0 and 41 + 6 weeks\' gestation. A baseline combined transabdominal and transperineal scan was performed, including assessment of fetal biometry, umbilical artery and fetal middle cerebral artery Doppler, amniotic fluid index, fetal spine and occiput positions, psAOP, HPD, SCD and cervical length. Intrapartum scans were performed instead of VE, unless there was a clinical indication to perform a VE, according to protocol. Participants were asked to indicate their level of pain by verbally giving a pain score between 0 and 10 (with 0 representing no pain) during assessment. Repeated measures data were analyzed using mixed-effect models to identify significant factors that affected the relationship between psAOP, HPD, SCD and mode of delivery.
    RESULTS: A total of 100 women were included in the study. Of these, 20% delivered by Cesarean section, 65% vaginally and 15% by instrumental delivery. There were no adverse fetal or maternal outcomes. A total of 223 intrapartum ultrasound scans were performed in 87 participants (13 women delivered before intrapartum ultrasound was performed), with a median of two scans per participant (interquartile range (IQR), 1-3). Of these, 76 women underwent a total of 151 VEs with a median of one VE per participant (IQR, 0-2), with no significant difference between vaginal- or Cesarean-delivery groups. After excluding those with epidural anesthesia during examination, the median pain score for intrapartum scans was 0 (IQR, 0-1) and for VE it was 3 (IQR, 0-6). Cesarean delivery was significantly associated with a slower rate of change in psAOP, HPD and SCD.
    CONCLUSIONS: Comprehensive transabdominal and transperineal ultrasound assessment can be used to assess progress in labor and can reduce the level of pain experienced during examination. Ultrasound assessment may be able to replace some transabdominal and vaginal examinations during labor. © 2024 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
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  • 文章类型: Journal Article
    背景:诊断为进展失败,最常见的剖宫产指征,是基于宫颈扩张和站随着时间的评估。分娩曲线可作为扩张和胎儿下降的预期变化的参考。弗里德曼的劳动曲线,Zhang等人和其他人是基于单独的时间,来自自发分娩的母亲。然而,引产现在很普遍,临床医生在评估分娩进展时也会考虑其他因素.考虑使用诱导和其他影响分娩进展的因素的分娩曲线有可能更准确,更接近临床决策。
    目的:使用2种建模方法:混合效应回归,比较基于单因素(时间)或多个临床相关因素的劳动曲线的预测误差,一种标准的统计方法,和高斯过程,一种机器学习方法。
    方法:这是一项关于扩张和体位变化的纵向队列研究,该研究基于8022例未分娩妇女的数据,单身人士,妊娠≥35周伴阴道分娩的胎儿顶点。通过10倍交叉验证,生成了新的扩张和站点劳动曲线。使用地理上独立的组进行外部验证。模型变量包括从交付前20小时的第一次检查开始的时间;膨胀,在先前检查中记录的消退和位置;累积收缩计数;以及硬膜外麻醉和引产的使用。要评估模型准确性,我们计算了每个模型的预测值与其相应的观察值之间的差异。使用平均绝对误差和均方根误差统计来总结这些预测误差。
    结果:(1)基于多个参数的扩张曲线比单独从时间得出的扩张曲线更准确。(2)多因素方法的平均绝对误差优于(低于)单因素方法[多因素机器学习法0.826cm(95%CI,0.820-0.832),多因素混合效应法0.893cm(95%CI,0.885-0.901),单因素法2.122cm(95%CI,2.108-2.136);两者比较P<0.0001]。(3)多因素方法的均方根误差也优于(低于)单因素方法的均方根误差[机器学习为1.126cm(95%CI,1.118-1.133)P<0.0001,混合效应为1.172cm(95%CI,1.164-1.181),单因素为2.504cm(95%CI,2.487-2.521);两者比较P<0.01]。(4)与混合效应回归模型相比,多因子机器学习膨胀模型在准确性上显示出较小但具有统计学意义的改进(P<0.0001)。(5)多因素机器学习方法产生的下降曲线平均绝对误差为0.512cm(95%CI,0.509-0.515),均方根误差为0.660cm(95%CI,0.655-0.666)。(6)使用独立数据的外部验证产生了类似的发现。
    结论:(1)与仅基于时间的模型相比,基于多个临床相关参数的宫颈扩张模型显示出改善(更低)的预测误差;(2)平均预测误差降低了50%以上;(3)对预期扩张和定位偏离的更准确评估可能有助于临床医生优化产期管理。
    The diagnosis of failure to progress, the most common indication for intrapartum cesarean delivery, is based on the assessment of cervical dilation and station over time. Labor curves serve as references for expected changes in dilation and fetal descent. The labor curves of Friedman, Zhang et al, and others are based on time alone and derived from mothers with spontaneous labor onset. However, labor induction is now common, and clinicians also consider other factors when assessing labor progress. Labor curves that consider the use of labor induction and other factors that influence labor progress have the potential to be more accurate and closer to clinical decision-making.
    This study aimed to compare the prediction errors of labor curves based on a single factor (time) or multiple clinically relevant factors using two modeling methods: mixed-effects regression, a standard statistical method, and Gaussian processes, a machine learning method.
    This was a longitudinal cohort study of changes in dilation and station based on data from 8022 births in nulliparous women with a live, singleton, vertex-presenting fetus ≥35 weeks of gestation with a vaginal delivery. New labor curves of dilation and station were generated with 10-fold cross-validation. External validation was performed using a geographically independent group. Model variables included time from the first examination in the 20 hours before delivery; dilation, effacement, and station recorded at the previous examination; cumulative contraction counts; and use of epidural anesthesia and labor induction. To assess model accuracy, differences between each model\'s predicted value and its corresponding observed value were calculated. These prediction errors were summarized using mean absolute error and root mean squared error statistics.
    Dilation curves based on multiple parameters were more accurate than those derived from time alone. The mean absolute error of the multifactor methods was better (lower) than those of the single-factor methods (0.826 cm [95% confidence interval, 0.820-0.832] for the multifactor machine learning and 0.893 cm [95% confidence interval, 0.885-0.901] for the multifactor mixed-effects method and 2.122 cm [95% confidence interval, 2.108-2.136] for the single-factor methods; P<.0001 for both comparisons). The root mean squared errors of the multifactor methods were also better (lower) than those of the single-factor methods (1.126 cm [95% confidence interval, 1.118-1.133] for the machine learning [P<.0001] and 1.172 cm [95% confidence interval, 1.164-1.181] for the mixed-effects methods and 2.504 cm [95% confidence interval, 2.487-2.521] for the single-factor [P<.0001 for both comparisons]). The multifactor machine learning dilation models showed small but statistically significant improvements in accuracy compared to the mixed-effects regression models (P<.0001). The multifactor machine learning method produced a curve of descent with a mean absolute error of 0.512 cm (95% confidence interval, 0.509-0.515) and a root mean squared error of 0.660 cm (95% confidence interval, 0.655-0.666). External validation using independent data produced similar findings.
    Cervical dilation models based on multiple clinically relevant parameters showed improved (lower) prediction errors compared to models based on time alone. The mean prediction errors were reduced by more than 50%. A more accurate assessment of departure from expected dilation and station may help clinicians optimize intrapartum management.
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  • 文章类型: Journal Article
    目的:探讨从潜伏到积极分娩的过渡持续时间与各种产科,母性,胎儿,和新生儿结局。
    方法:对足月进行了回顾性队列研究,2013年至2018年在索罗卡大学医学中心分娩。数据是从电子病历中提取的。暴露变量被定义为延长过渡,它本身被定义为从4到6厘米的扩张持续时间的上10个百分位数。使用χ2检验比较临床和人口统计学特征。使用多变量逻辑回归来估计延长过渡与每种不良结局的贡献,以调整潜在的混杂因素。
    结果:总而言之,12104次交付符合纳入标准。从4到6cm的扩张持续时间的平均值±标准偏差为03:07:58±03:03:42(小时:分钟:秒)。在具有不同产科和人口统计学特征的患者中,进展曲线差异显着。延长的过渡与剖宫产的风险增加显着相关(调整后的几率为2.607,95%置信区间为2.171-3.130,曲线下面积0.689)以及更高的孕产妇和新生儿发病率。
    结论:经历超过90分的过渡阶段的患者面临剖宫产和产后并发症的风险增加。未来的研究应集中在过渡阶段的干预措施,以改善妊娠结局并提高患者安全性。
    OBJECTIVE: To explore the relationship between the duration of transition from latent to active labor and various obstetric, maternal, fetal, and neonatal outcomes.
    METHODS: A retrospective cohort study was conducted on term, singleton deliveries at Soroka University Medical Center from 2013 to 2018. Data were extracted from electronic medical records. The exposure variable was defined as prolonged transition, which was itself defined as the upper 10th centile of dilation duration from 4 to 6 cm. Clinical and demographic characteristics were compared using χ2 test. Multivariate logistic regression was used to estimate the contribution of a prolonged transition with each adverse outcome adjusting for potential confounders.
    RESULTS: In all, 12 104 deliveries met the inclusion criteria. The mean ± standard deviation of duration of dilation from 4 to 6 cm was 03:07:58 ± 03:03:42 (hours:minutes:seconds). Progress curves varied significantly among patients with different obstetrical and demographic characteristics. Prolonged transition was significantly linked to an increased risk of cesarean delivery (adjusted odds raito 2.607, 95% confidence interval 2.171-3.130, area under the curve 0.689) and higher rates of maternal and neonatal morbidity.
    CONCLUSIONS: Patients experiencing transition phases exceeding the 90th centile faced an elevated risk of cesarean delivery and postpartum complications. Future studies should focus on interventions during the transition phase to improve pregnancy outcomes and enhance patient safety.
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