■血管内大B细胞淋巴瘤(IVLBCL)是一种罕见且侵袭性的B细胞淋巴瘤,大细胞在血管腔内生长。尽管以前的报道显示,由于各种器官中肿瘤细胞的小血管阻塞引起的症状高度可变,关于垂体受累的IVLBCL的报道很少。
■我们介绍了我们机构的一例患有垂体浸润的IVLBCL,并对类似病例进行了文献综述,以更好地了解这种罕见的涉及垂体的IVLBCL病例。
我们的病例和相关文献表明,垂体受累的IVLBCL主要发生在平均年龄为64岁的女性中。大多数患者在鞘内注射甲氨蝶呤的含利妥昔单抗的化疗标准治疗后表现为可逆的全垂体功能减退.值得注意的是,我们病例的垂体活检显示血管和垂体内发现的非典型大B细胞的细胞间粘附分子1阴性。细胞间粘附分子1阴性淋巴样细胞可能通过外渗到垂体组织中而导致全垂体功能减退。没有血脑屏障并获得丰富的血流。
■垂体的IVLBCL是一种罕见的非特异性表现和预后不良的淋巴瘤。临床病理特征的识别对于早期临床诊断和适当治疗是必要的。
UNASSIGNED: Intravascular large B-cell lymphoma (IVLBCL) is a rare and aggressive type of B-cell lymphoma with large cells growing within the lumen of blood vessels. Although previous reports revealed highly variable symptoms resulting from small-vessel occlusion by neoplastic cells in a variety of organs, there are few reports of IVLBCL with pituitary involvement.
UNASSIGNED: We present a case of IVLBCL with pituitary infiltration from our institution together with a literature review of similar cases to better understand this rare case of IVLBCL involving the pituitary gland.
UNASSIGNED: Our case and the pertinent literature demonstrated that IVLBCL with pituitary involvement predominantly occurred in women at a mean age of 64 years, and most of them showed panhypopituitarism that was reversible after standard therapy of rituximab-containing chemotherapy with intrathecal methotrexate. Notably, the pituitary biopsy in our case revealed that atypical large B-cells found within blood vessels and the pituitary gland were negative for intercellular adhesion molecule 1. Intercellular adhesion molecule 1-negative lymphoid cells may have contributed to panhypopituitarism by extravasation into the pituitary tissues, which do not have a blood-brain barrier and receive abundant blood flow.
UNASSIGNED: IVLBCL of the pituitary gland is a rare lymphoma with nonspecific manifestations and a dismal prognosis. Recognition of the clinicopathological features is necessary for early clinical diagnosis and appropriate treatment.