■多囊卵巢综合征(PCOS)是导致不孕的最重要因素之一。PCOS的诊断不是一个简单的过程,因为体征和症状是异质的,病因不明。只有少数已发表的研究针对抗苗勒管激素在包括苏丹在内的撒哈拉以南非洲的PCOS诊断中的诊断性能。
■本研究旨在评估抗苗勒管激素(AMH),促黄体生成与促卵泡激素比例(LH:FSH),总睾酮(TT),和PCOS中的催乳素(PRL)水平。此外,我们确定AMH是否可作为苏丹女性PCOS的预测因子.
■有600名妇女参加了这项观察性横断面研究,其中300人患有PCOS,300名健康女性;PCOS使用鹿特丹标准诊断。在月经周期的第2-4天,血清LH,FSH,AMH,TT,测量所有参与者的PRL水平。通过受试者工作特征(ROC)曲线确定这些参数对PCOS的诊断性能。
■在PCOS中,关于他们的BMI,AMH;LH:FSH比值;TT;PRL,而与正常排卵妇女相比,FSH明显相反。在ROC分析中,AMH在截止值>3.95ng/mL时具有最大的工作特性曲线;AUC=0.999,Youden指数为0.99%,其次是LH:FSH比值,截止0.749;AUC=0.932;尤登指数0.813%,TT截止0.82mIU/L,AUC=0.852,Youden指数为0.58,而PRL显示最低AUC=0.627,截止值15.3ng/mL,尤登指数为0.18%,P.值<0.001。
■苏丹PCOS妇女血清AMH水平较高,LH:FSH比率,TT级别。此外,AMH水平对苏丹人PCOS的诊断具有较好的判别力和较好的诊断效能。
UNASSIGNED: Polycystic ovary syndrome (PCOS) is one of the most important contributing factors to infertility. The diagnosis of PCOS is not an easy procedure, as the signs and symptoms are heterogeneous and of undefined etiology. There are only a few published studies that address the diagnostic performance of anti-Müllerian hormone in diagnosis of PCOS in sub-Saharan Africa including Sudan.
UNASSIGNED: This study aims to assess anti-Müllerian hormone (AMH), luteinizing to follicle-stimulating hormone ratio (LH: FSH), total testosterone (TT), and prolactin (PRL) levels among PCOS. In addition, we determine if AMH can be used as a predictor of PCOS among Sudanese women.
UNASSIGNED: There were 600 women enrolled in this observational cross-sectional study, 300 of whom had PCOS, and 300 of whom healthy women; PCOS was diagnosed using the Rotterdam criteria. On days 2-4 of the menstrual cycle, serum LH, FSH, AMH, TT, and PRL levels were measured for all participants. Diagnostic performance of these parameters for PCOS was determined by receiver operating characteristic (ROC) curve.
UNASSIGNED: Significantly higher means among PCOS regarding their BMI, AMH; LH: FSH ratio; TT; PRL, whereas significantly inverse in FSH compared with normal ovulatory women. On ROC analysis, AMH had the largest operating characteristic curve at cut-off >3.95 ng/mL; AUC = 0.999 with Youden\'s index 0.99%, followed by LH: FSH ratio at cut-off 0.749; AUC=0.932; Youden\'s index 0.813%, TT cut-off 0.82 mIU/L, AUC=0.852 with Youden\'s index 0.58, while PRL showed the lowest AUC=0.627 with cut-off 15.3 ng/mL, Youden\'s index was 0.18%, P. value<0.001.
UNASSIGNED: Sudanese women with PCOS had higher serum AMH level, LH:FSH ratio, and TT level. Moreover, AMH level has better discriminative power and good diagnostic potency for the diagnosis of PCOS among Sudanese.