■对羟基苯甲酸酯,它们是化妆品和药品中用作防腐剂的化学物质,据报道,在动物和人体模型中,精子质量低。尽管尼日利亚男性大量接触含有对羟基苯甲酸酯的产品,在这个国家,没有已知的研究调查对羟基苯甲酸酯与精子质量的关系。
■确定对羟基苯甲酸酯代谢物的尿水平与精子数量和质量的关系。
■尼日利亚南部五家医院的肥沃和不育男性的多中心病例对照研究。将总共136名被诊断为男性不育症(病例)的男性与154名正常生育能力的对照进行了比较。对羟基苯甲酸酯(对羟基苯甲酸乙酯,对羟基苯甲酸甲酯,对羟基苯甲酸丙酯,和对羟基苯甲酸丁酯)使用液相色谱质谱法测量,而精液分析和激素测定是使用世界卫生组织标准和放射免疫测定法进行的,分别。数据采用非参数统计和非参数线性回归分析。
■结果显示对羟基苯甲酸酯在病例和对照中均有高水平的存在。然而,对羟基苯甲酸乙酯的尿水平没有统计学上的显著差异,对羟基苯甲酸甲酯,对羟基苯甲酸丙酯,病例和对照之间的对羟基苯甲酸丁酯。相比之下,在两组中,对羟基苯甲酸丙酯与总运动性的相关性均降低,但效果仅在男性不育的情况下具有统计学意义。回归分析的结果表明,对羟基苯甲酸丙酯的单位增加可显着降低病例(不育男性)的总动力。同样,在未调整的不育男性模型中,对羟基苯甲酸丙酯的单位增加显着降低了形态学。只有血清睾酮与尿对羟基苯甲酸酯无明显相关性。
■我们得出结论,对羟基苯甲酸尿酯与精子质量差的特征-运动性有关,形态学,和音量。在尼日利亚减少男性接触含有对羟基苯甲酸酯的药物的措施可能会降低该国男性不育症的患病率。
UNASSIGNED: Parabens, which are chemicals used as preservatives in cosmetic and pharmaceutical products, have been reported to be associated with low sperm quality in animal and human models. Despite the high exposure of men to paraben-containing products in Nigeria, there are no known studies that investigate the association of parabens with sperm quality in the country.
UNASSIGNED: To determine the association of urinary levels of metabolites of parabens with sperm count and quality.
UNASSIGNED: A multicenter case-control study among fertile and infertile men in five hospitals in southern Nigeria. A total of 136 men diagnosed with male infertility (cases) were compared with 154 controls with normal fertility. Urinary levels of parabens (ethyl-paraben, methylparaben, propylparaben, and butylparaben) were measured using liquid chromatography mass spectrometry, while semen analysis and hormone assays were carried out using World Health Organization standards and radioimmunoassay, respectively. Data were analyzed with non-parametric statistics and non-parametric linear regression.
UNASSIGNED: The results showed high levels of parabens in both cases and controls. However, there was no statistically significant difference in urinary levels of ethyl-paraben, methylparaben, propylparaben, and butylparaben between cases and controls. In contrast, propylparaben had a decreasing association with total motility in both groups, but the effect was only statistically significant in the case of male infertility. The results of the regression analysis showed that a unit increase in propylparaben significantly decreased total motility in the cases (infertile men). Similarly, a unit increase in propylparaben decreased morphology significantly in the unadjusted model for infertile men. Only serum testosterone showed an insignificant correlation with urinary parabens.
UNASSIGNED: We conclude that urinary parabens are associated with features of poor sperm quality - motility, morphology, and volume. Measures to reduce exposure of men to agents containing parabens in Nigeria may reduce the prevalence of male infertility in the country.