■L-天冬酰胺酶在治疗小儿急性淋巴细胞白血病(ALL)中很有价值,然而,它的使用与脂质分布紊乱有关。
■我们比较了血脂谱[高密度脂蛋白(HDL)胆固醇,低密度脂蛋白(LDL)胆固醇,总胆固醇,甘油三酯,载脂蛋白-α1(Apo-Α1),载脂蛋白-B100(Αpo-B100),脂蛋白-α(Lp-α),葡萄糖,淀粉酶,和脂肪酶]在新诊断的所有患者之间,所有幸存者,和健康的控制。我们还评估了诱导和巩固治疗期间前面提到的参数的变化。
■我们记录了与对照组相比,诊断为ALL儿童的血脂谱的显着差异(HDL胆固醇,甘油三酯,Apo-A1和Apo-B100水平)。HDL胆固醇,总胆固醇,和Apo-Α1水平在诱导期间在大多数时间点显著增加。Apo-B100、甘油三酯、Lp-α呈下降趋势。在重新感应期间,没有观察到变化。在高危患者的治疗过程中,我们发现任何检查变量均无统计学显著差异.
■为了确认我们的初步结果,L-天冬酰胺酶和其他药物在诊断儿童ALL时血脂变化中的作用需要通过更大规模的多中心研究进一步阐明,包括更多来自不同种族背景的患者。HIPPOKRATIA2023,27(2):41-47.
UNASSIGNED: L-asparaginase is valuable in treating pediatric acute lymphoblastic leukemia (ALL), yet its use has been associated with lipid profile disturbances.
UNASSIGNED: We compared the lipid profile [high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, total cholesterol, triglycerides, apolipoprotein-α1 (Apo-Α1), apolipoprotein-B100 (Αpo-B100), lipoprotein-α (Lp-α), glucose, amylase, and lipase] between newly diagnosed ALL patients, ALL survivors, and healthy controls. We also assessed alterations of the parameters mentioned earlier during induction and consolidation treatment.
UNASSIGNED: We recorded significant differences in the lipid profile at diagnosis of children with ALL compared to controls (HDL cholesterol, triglycerides, Apo-A1, and Apo-B100 levels). HDL cholesterol, total cholesterol, and Apo-Α1 levels increased significantly during induction at most time points. Levels of Αpo-B100, triglycerides, and Lp-α exhibited a downward trend. During re-induction, no change was observed. During the treatment of high-risk patients, we found no statistically significant difference for any of the examined variables.
UNASSIGNED: To confirm our preliminary results, the role of the administration of L-asparaginase and other medications in the variations in the lipid profile at diagnosis of children with ALL needs to be further elucidated with larger multicentre studies, including more patients from diverse ethnic backgrounds. HIPPOKRATIA 2023, 27 (2):41-47.