视-肌阵鸣综合征(OMS),也被称为Kinsbourne综合症或跳舞的眼睛综合症,是一种极为罕见的神经系统疾病,包括一系列异质性症状,包括视阵鸣以及弥漫性或局灶性肌阵鸣。它通常被称为副肿瘤实体,但它也可能与传染病有关,新陈代谢,或特发性原因。肺小细胞癌是最常见的与OMS相关的恶性肿瘤。作者描述了一例69岁男性出现共济失调步态的病例,语音和畏光,眩晕,头晕,嗜睡,恶心,和呕吐。考试期间,快速,多向眼球运动;轻微构音障碍;并注意到面部肌阵鸣。他被送进了医院,经过彻底的研究,建立了OMS的诊断。开始静脉注射皮质类固醇,除了物理治疗,并注意到他的症状略有改善。成像显示左肺有可疑病变,伴随淋巴结病和骨转移.组织学证实诊断为IV期小细胞肺癌(SCLC)。开始使用卡铂和依托泊苷进行化疗(ChT),并注意到他的神经系统疾病逐渐改善。经过六个周期,疾病进展,并开始了与托普替康的二线ChT。经过两个周期,患者经历了显著的临床恶化并最终死亡.总之,OMS是一种鲜为人知的疾病,神经系统预后不确定。原发性肿瘤的治疗可以改善神经症状。副肿瘤综合征的识别至关重要,因为恶性肿瘤的早期诊断与更好的预后有关。
Opsoclonus-myoclonus syndrome (OMS), also known as Kinsbourne syndrome or dancing eyes syndrome, is an extremely rare neurological condition that comprises a heterogenous constellation of symptoms including opsoclonus along with diffuse or focal body myoclonus. It is usually referred to as a paraneoplastic entity, but it may also be associated to an infectious, metabolic, or idiopathic cause. Small-cell carcinoma of the lung is the most commonly reported malignancy associated with OMS. The authors describe a case of a 69-year-old male that presented with ataxic gait, phono- and photophobia, vertigo, dizziness, lethargy, nausea, and vomiting. During examination, rapid, multidirectional eye movements; slight dysarthria; and facial myoclonus were noted. He was admitted to the hospital, and after a thorough study, a diagnosis of OMS was established. Intravenous corticosteroids were started, alongside physiotherapy, and a slight improvement of his symptoms was noted. Imaging revealed a suspicious lesion in the left lung, along with lymphadenopathies and bone metastases. Histology confirmed the diagnosis of stage IV small-cell lung cancer (SCLC). Chemotherapy (ChT) with carboplatin and etoposide was started, and a gradual improvement of his neurological complaints was noted. After six cycles, the disease progressed, and second-line ChT with topotecan was started. After two cycles, the patient experienced significant clinical deterioration and eventually died. In conclusion, OMS is a poorly understood condition with uncertain neurological prognosis. The treatment of the primary neoplasm may improve neurological symptoms. The recognition of paraneoplastic syndromes is of utmost importance since early diagnosis of a malignancy relates to better outcomes.