最近,与靶向基因治疗和诊断相关的主题在疾病研究中变得越来越重要。许多疾病的进展与特定的基因信号通路有关。因此,在各种疾病中识别精确的基因靶标对于开发有效的治疗方法至关重要。层粘连蛋白亚基β3(LAMB3),层粘连蛋白5的组成部分,在细胞外基质中起粘附蛋白的作用,在调节细胞增殖中起着至关重要的作用,迁移,和某些疾病的细胞周期。先前的研究表明,LAMB3在许多肿瘤和非肿瘤条件下高度表达,包括肾纤维化;皮肤鳞状细胞癌,甲状腺,肺,胰腺,卵巢,结肠直肠,胃,乳房,子宫颈,鼻咽,膀胱,前列腺癌;和胆管癌。相反,它在其他条件下被低估了,比如肝细胞癌,大疱性表皮松解症,和牙釉质发育不全。因此,LAMB3可能通过参与关键基因信号通路作为多种疾病的分子诊断和治疗靶点。本文就LAMB3的研究现状及其在相关疾病中的作用作一综述。
Recently, topics related to targeted gene therapy and diagnosis have become increasingly important in disease research. The progression of many diseases is associated with specific gene signaling pathways. Therefore, the identification of precise gene targets in various diseases is crucial for the development of effective treatments. Laminin subunit beta 3 (LAMB3), a component of laminin 5, functions as an adhesive protein in the extracellular matrix and plays a vital role in regulating cell proliferation, migration, and cell cycle in certain diseases. Previous studies have indicated that LAMB3 is highly expressed in numerous tumorous and non-tumorous conditions, including renal fibrosis; squamous cell carcinoma of the skin, thyroid, lung, pancreatic, ovarian, colorectalr, gastric, breast, cervical, nasopharyngeal, bladder, prostate cancers; and cholangiocarcinoma. Conversely, it is underexpressed in other conditions, such as hepatocellular carcinoma, epidermolysis bullosa, and amelogenesis imperfecta. Consequently, LAMB3 may serve as a molecular diagnostic and therapeutic target for various diseases through its involvement in critical gene signaling pathways. This paper reviews the research status of LAMB3 and its role in related diseases.