背景:KRT80是人类上皮中间丝II型基因;其表达产物是细胞内中间丝(IF)的组成部分,并参与细胞骨架的组装。有证据表明,IFs主要在核周区域形成密集的网络,但它们也可以到达大脑皮层。它们对于细胞的机械缓冲是必不可少的,细胞器定位,细胞凋亡,迁移,附着力,以及与其他细胞骨架成分的相互作用。人类拥有54个功能性角蛋白基因,而KRT80是比较独特的基因之一。它在几乎所有的上皮细胞中广泛表达,尽管在结构上与II型上皮角蛋白更相似。
目的:在这篇综述中,我们总结了角蛋白家族和KRT80的基本事实,KRT80在肿瘤中的重要作用,以及它作为治疗靶点的潜力。我们希望这篇综述能激励研究人员至少部分关注这一领域。
结果:在许多肿瘤疾病中,KRT80的高表达状态及其在调节癌细胞生物学功能中的作用已经很好地确立。KRT80能有效增强增殖,癌细胞的侵袭和迁移。然而,KRT80对各种癌症患者预后和临床相关指标的影响尚未得到广泛研究,在同一癌症的不同研究中,甚至得出了相反的结论。基于此,我们应该增加更多的临床相关研究,以阐明KRT80的临床应用前景。许多研究人员在研究KRT80的作用机制方面取得了很大进展。然而,他们的研究应该扩展到更多的癌症,以发现不同癌症中KRT80的共同调节因子和信号通路.KRT80可能对人体产生深远的影响,这种标志物可能在癌细胞的功能和癌症患者的预后中起着至关重要的作用,因此,它在肿瘤领域具有广阔的前景。
结论:在肿瘤疾病中,KRT80在许多癌症中过度表达,并在促进增殖方面发挥重要作用。迁移,侵袭性和预后不良。已经部分阐明了KRT80在癌症中的作用机制。表明KRT80是一个潜在有用的癌症治疗靶点。然而,更系统,在这一领域仍需要深入和全面的研究。
KRT80 is a human epithelial intermediate filament type II gene; its expression product is a component of intracellular intermediate filaments (IFs) and is involved in the assembly of the cytoskeleton. There is evidence that IFs form a dense network mainly in the perinuclear area, but they can also reach the cortex. They are essential for mechanical cushioning of cells, organelle positioning, cell apoptosis, migration, adhesion, and interactions with other cytoskeletal components. Humans possess 54 functional keratin genes, and
KRT80 is one of the more unique genes. It is widely expressed in almost all epithelial cells, although it is structurally more similar to type II hair keratins than to type II epithelial keratins.
In this review, we summarize the basic facts about the keratin family and KRT80, the essential role of
KRT80 in neoplasms, and its potential as a therapeutic target. We hope that this review will inspire researchers to at least partially focus on this area.
In many neoplastic diseases, the high expression status of KRT80 and its role in regulating the biological functions of cancer cells have been well established. KRT80 can effectively enhance the proliferation, invasiveness and migration of cancer cells. However, the effects of KRT80 on prognosis and clinically relevant indices in patients with various cancers have not been extensively studied, and even opposite conclusions have been reached in different studies of the same cancer. Based on this, we should add more clinically relevant studies to clarify the prospect of clinical application of KRT80. Many researchers have made great progress in studying the mechanism of action of
KRT80. However, their studies should be extended to more cancers to find common regulators and signaling pathways of KRT80 in different cancers. KRT80 may have far-reaching effects on the human body, and this marker may play a crucial role in the function of cancer cells and the prognosis of cancer patients, so it has a promising future in the field of neoplasms.
In neoplastic diseases, KRT80 is overexpressed in many cancers and plays an essential role in promoting proliferation, migration, invasiveness and poor prognosis. The mechanisms of
KRT80 functions in cancer have been partially elucidated, suggesting that
KRT80 is a potentially useful cancer therapeutic target. However, more systematic, in-depth and comprehensive studies are still needed in this field.