■真菌性鼻-鼻窦炎(FRS)病例在世界范围内并不罕见。然而,他们作为后COVID后遗症的飙升震惊了世界,尤其是印度。在此类免疫功能低下的患者中,与急性侵袭性真菌性鼻-鼻窦炎(AIFR)相关的高死亡率和不良预后加剧了困境。在这种情况下,AIFR的早期和精确诊断是患者和医生所依赖的。KOH和组织病理学是FRS诊断的两个前线研究。我们的研究旨在通过组织病理学分析FRS的病例,并将其与KOH进行比较。
■前瞻性纵向研究,包括疑似COVID后FRS患者,为期1.5个月。他们的临床,组织病理学,和KOH的发现然后相关。
■在组织病理学上发现约72.5%的临床疑似真菌感染标本对真菌元素呈阳性。其中,只有30例KOH贴装阳性。最大的患者年龄为40-70岁;男性(67%)多于女性。涉及的部位是鼻旁窦(100%),鼻部(88%),和轨道(25%)。组织病理学显示毛霉菌病(100%)和曲霉病(16%)。在38%的毛霉菌病病例中发现了血管侵袭。
■在危机状态下,当真菌鉴定的黄金标准,即培养可能需要多达21天的最终报告,早期和明智的抗真菌治疗是恢复的必要条件,就真菌元素及其侵袭的早期和精确诊断而言,组织病理学已证明比KOH更好。
UNASSIGNED: Fungal rhinosinusitis (FRS) cases are not exiguous for the world. However, their spike as a postCOVID sequelae has alarmed the world, especially India. Adding to the woes is the high mortality rate and poor prognosis associated with acute invasive fungal rhinosinusitis (AIFR) in such immunocompromised patients. In such a scenario, early and precise diagnosis of AIFR is what a patient and physician banks upon.
KOH and histopathology are the two frontline investigations for the diagnosis of FRS. Our study aimed at analyzing the cases of FRS by histopathology and comparing these with
KOH.
UNASSIGNED: Prospective longitudinal study including suspected postCOVID FRS patients over a period of 1.5 months. Their clinical, histopathological, and
KOH findings were then correlated.
UNASSIGNED: About 72.5% clinically suspected fungal infection specimens were found to be positive for fungal elements on histopathology. Of these, only 30 cases were positive by
KOH mount. Maximum patients belonged to 40-70 years of age; males (67%) more than females. Sites involved were paranasal sinuses (100%), nasal (88%), and orbital (25%). Histopathology revealed mucormycosis (100%) and aspergillosis (16%). Angioinvasion was identified in 38% of the mucormycosis cases.
UNASSIGNED: In a state of crisis, when the gold standard for fungal identification i.e., culture can take as many as 21 days for final report and early and judicious antifungal treatment is sine qua non of recovery, histopathology has proved to be better than
KOH as far as early and precise diagnosis of fungal elements and their invasion is concerned.