背景:BCAAs(异亮氨酸,亮氨酸,和缬氨酸)与心脑血管疾病已被研究人员广泛认可,但支持老年BCAA与多种慢性疾病(MCC)之间关系的证据有限.本研究旨在探讨老年人饮食中BCAA水平与MCC之间的相关性。
方法:基于深圳市南山区健康管理队列项目,从2018年5月至2019年12月,通过多阶段分层抽样选择4278名65岁以上的个体作为参与者。使用经过验证的半定量食物频率问卷收集数据,以及人体测量和慢性病报告。MCC被定义为两种或两种以上慢性疾病并存,即,高血压,血脂异常,糖尿病,CAD,中风,CKD,和CLD。采用多因素非条件logistic回归分析老年人膳食BCAAs与MCCs的关系,然后,进行性别分层分析.使用受限的三次样条模型(拟合的平滑曲线)来确定异亮氨酸与MCC的剂量反应关系。
结果:本研究共纳入4278名65岁及以上的老年人,平均年龄72.73±5.49岁。该队列包括1861名男性(43.50%)。不管混杂因素是否得到纠正,异亮氨酸是MCCs的危险因素(OR=3.388,95CI:1.415,8.109)。性别分层后,女性饮食中异亮氨酸与MCCs(OR=6.902,95CI:1.875,25.402)和亮氨酸(OR=0.506,95CI:0.309,0.830)与MCCs的关系显著,但不是男人。未观察到缬氨酸和MCC之间的显著关联。此外,当异亮氨酸摄入量大于4.297g/d时,是MCC的危险因素。
结论:异亮氨酸可能在调节年龄相关疾病中起重要作用。BCAAs如异亮氨酸可用作老年人MCC的风险标志物。
BACKGROUND: The association of BCAAs (
isoleucine, leucine, and valine) with cardiovascular and cerebrovascular diseases has been widely recognized by researchers, but there is limited evidence to support the relationship between BCAAs and multiple chronic conditions (MCCs) in older adults. This study aimed to explore the correlation between BCAA levels in the diets of older adults and MCCs.
METHODS: Based on a health management cohort project in Nanshan District of Shenzhen, 4278 individuals over 65 years old were selected as participants via multi-stage stratified sampling from May 2018 to December 2019. Data were collected using a validated semi-quantitative food frequency questionnaire, as well as anthropometric and chronic disease reports. MCC was defined as the coexistence of two or more chronic diseases, namely, hypertension, dyslipidemia, diabetes, CAD, stroke, CKD, and CLD. Multivariate unconditional logistic regression analysis was used to analyze the relationship between dietary BCAAs and MCCs in older adults, and then, gender stratification analysis was performed. A restricted cubic spline model (a fitted smooth curve) was used to determine the dose-response relationship of isoleucine with MCCs.
RESULTS: A total of 4278 older adults aged 65 and above were included in this study, with an average age of 72.73 ± 5.49 years. The cohort included 1861 males (43.50%). Regardless of whether confounding factors were corrected,
isoleucine was a risk factor for MCCs (OR = 3.388, 95%CI:1.415,8.109). After gender stratification, the relationships between dietary isoleucine and MCCs (OR = 6.902, 95%CI:1.875,25.402) and between leucine (OR = 0.506,95%CI:0.309,0.830) and MCCs were significant in women, but not in men. No significant association between valine and MCCs was observed. In addition,
isoleucine was a risk factor for MCCs when its intake was greater than 4.297 g/d.
CONCLUSIONS: Isoleucine may play an important role in regulating age-related diseases. BCAAs such as
isoleucine can be used as risk markers for MCCs in older adults.