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  • 文章类型: Journal Article
    孤立的掌侧远端尺尺关节(DRUJ)脱位是一种罕见的疾病,文献中仅报道了少数病例。其诊断在急性期常被忽视,它的管理没有共识。我们介绍了一名20岁的男性患者的情况,该患者患有孤立的掌侧radioulnar脱位,以及文献综述。目的是介绍和总结这种疾病的急性治疗方法,并提出一种治疗算法。
    Isolated volar distal radioulnar joint (DRUJ) dislocation is a rare condition with only a few cases reported in the literature. Its diagnosis is often overlooked in the acute phase, and there is no consensus in its management. We present the case of a 20-year-old male patient with an isolated volar radioulnar dislocation, together with a review of the literature. The aim is to present and summarize the acute management of this condition and propose a therapeutic algorithm.
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  • 文章类型: Case Reports
    肱三头肌腱断裂是罕见但严重的损伤,会损害上肢功能。尽管他们的频率不高,认识到这种情况是至关重要的,因为它严重影响手臂的运动和力量。患者通常表现为肘部后部疼痛,肿胀,还有瘀伤.本报告详细介绍了一名34岁男性受伤后的三头肌腱完全断裂。患者表现出经典症状:肘部后部疼痛,显著肿胀,和可见的瘀伤,最初提示严重的软组织损伤。临床检查和影像学证实三头肌腱完全断裂。该病例强调了在症状相似的患者中考虑肱三头肌腱断裂的重要性,特别是创伤后。早期识别和准确诊断对于及时手术干预至关重要,显著提高功能恢复。延迟诊断和治疗可能导致长期残疾和不良预后。强调需要提高医疗保健提供者对这种罕见但严重的伤害的认识。
    Triceps tendon ruptures are rare but significant injuries that impair upper extremity function. Despite their infrequency, recognizing this condition is crucial due to its severe impact on arm movement and strength. Patients typically present with posterior elbow pain, swelling, and bruising.This report details a complete triceps tendon rupture in a 34-year-old male following trauma. The patient exhibited classic symptoms: posterior elbow pain, significant swelling, and visible bruising, initially suggesting a severe soft tissue injury. Clinical examination and imaging confirmed a complete triceps tendon rupture. This case highlights the importance of considering triceps tendon rupture in patients with similar symptoms, particularly after trauma. Early recognition and accurate diagnosis are essential for timely surgical intervention, significantly improving functional recovery. Delayed diagnosis and treatment can lead to prolonged disability and poor outcomes, emphasizing the need for heightened awareness among healthcare providers regarding this rare but serious injury.
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  • 文章类型: Case Reports
    孤立的自发性肠系膜上动脉(SMA)夹层相对罕见。经常在横断面成像上偶然发现,经常非手术管理。我们介绍了一名出现胸痛并被发现患有SMA夹层的患者。
    Isolated spontaneous superior mesenteric artery (SMA) dissection is relatively rare. Often found incidentally on cross-sectional imaging, often managed non-operatively. We present a patient who presented with chest pain and was found to have a SMA dissection.
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  • 文章类型: Journal Article
    孤独,抑郁症,焦虑在美国成年人中非常普遍,特别是在社会人口脆弱人群中。虚拟对等支持具有潜在的成本效益,可扩展的干预。这项研究前瞻性地评估了数字支持对243名有症状抑郁症的脆弱成年人的心理健康结果和估计的医疗费用降低的影响。焦虑,和显著的孤独。我们发现来自不同种族/民族的参与者,性别和社会经济群体在同伴支持下参与,他们的精神健康在统计和临床上都有显著改善,估计每位参与者每年的医疗费用减少1,025美元。我们相信,这项工作将为正在进行的讨论提供信息,这些讨论涉及使用数字支持的同伴支持来解决美国的心理健康危机。
    This study prospectively evaluated the effects of digitally enabled peer support on mental health outcomes and estimated medical cost reductions among vulnerable adults with symptomatic depression, anxiety, and significant loneliness to address the mental health crisis in the United States.
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  • 文章类型: Case Reports
    背景:恶性黑色素瘤是一种高侵袭性肿瘤,预后极差。MM的常见转移见于肺部,中枢神经系统,肝脏,淋巴结和孤立的脊柱转移瘤极为罕见。据我们所知,仅报道了一例MM的孤立性腰椎转移瘤。
    方法:一名80岁女性,表现为上胸椎疼痛和双侧下肢进行性无力。她给出了鼻子复发性MM的病史,为此她接受了两次肿瘤切除。经检查,她的步态痉挛,下肢反射过度,下肢运动等级为3/5。胸椎的MRI扫描显示分叶状增强肿块,涉及T3椎体的右半部分和相应的后部元素。患者接受了姑息性脊柱减压术和肿瘤切除术。组织病理学证实MM。术后进行的PET扫描排除了任何其他转移部位。
    结论:尽管MM脊柱转移瘤的孤立表现极为罕见,临床怀疑和先进的影像学检查有助于早期诊断。治疗策略应以目前的神经状况为指导,肿瘤的性质,存在机械不稳定和患者接受手术干预的适应性。
    结论:诊断为MM的患者应密切随访,即使原发部位没有任何复发。即使在疾病晚期,手术减压也可以改善神经系统症状并减轻疼痛,从而改善生活质量。
    BACKGROUND: Malignant melanoma is a highly invasive tumor with very poor prognosis. Common metastases of MM are noted in lungs, Central nervous system, liver, lymph nodes and isolated spinal metastases are extremely rare. To our knowledge only one case of isolated lumbar spinal metastases of MM was reported.
    METHODS: An 80-year-old female presented with pain at upper thoracic spine and progressive weakness of bilateral lower limbs. She gives history of recurrent MM of nose, for which she underwent excision of tumor twice. On examination she had spastic gait with exaggerated lower limb reflexes and lower limb motor grade of 3/5. The MRI scan of thoracic spine revealed lobulated enhancing mass involving the right half of the T3 vertebral body and corresponding posterior elements. The patient underwent palliative spinal decompression and excision of tumor. Histopathology confirmed MM. The PET scan done post operatively ruled out any other sites of metastases.
    CONCLUSIONS: Though the incidence of isolated manifestation of spinal metastases of MM is extremely rare, clinical suspicion and advanced imaging can help to diagnose early. The treatment strategy should be guided by current neurological status, nature of the tumor, presence of mechanical instability and patient\'s fitness to undergo surgical intervention.
    CONCLUSIONS: Patient diagnosed with MM should be closely followed up even in absence of any recurrence at the primary site. Surgical decompression can improve neurological symptoms and decrease pain to improve quality of life even at advanced stage of the disease.
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  • 文章类型: Journal Article
    包括糖尿病足溃疡(DFU)的糖尿病伤口感染是主要的全球健康问题和非创伤性截肢的主要原因。许多细菌物种在DFU中建立感染,和抗生素治疗通常由于广泛的抗生素耐药性和生物膜形成而失败。确定存在于DFU中的细菌种类及其毒力潜力对于告知治疗选择至关重要。这里,我们在科罗拉多大学Anschutz医学中心从糖尿病患者的清创组织中分离细菌.最常见的物种是革兰氏阳性,包括粪肠球菌,金黄色葡萄球菌,和无乳链球菌,也称为B族链球菌(GBS)。大多数组织具有一种以上的用粪肠球菌和GBS分离的物种,其经常发生在金黄色葡萄球菌的多微生物感染中。金黄色葡萄球菌是最佳的生物膜产生物种,粪肠球菌和GBS分离株表现出很少至没有生物膜形成。抗生素敏感性在金黄色葡萄球菌中具有高水平青霉素抗性的菌株之间存在差异,GBS中的克林霉素抗性和粪肠球菌中的万古霉素抗性。最后,我们利用了糖尿病伤口感染的小鼠模型,发现与单一感染的小鼠相比,金黄色葡萄球菌的存在导致GBS和粪肠球菌的恢复显著更高.
    Diabetic wound infections including diabetic foot ulcers (DFUs) are a major global health concern and a leading cause of non-traumatic amputations. Numerous bacterial species establish infection in DFUs, and treatment with antibiotics often fails due to widespread antibiotic resistance and biofilm formation. Determination of bacterial species that reside in DFU and their virulence potential is critical to inform treatment options. Here, we isolate bacteria from debridement tissues from patients with diabetes at the University of Colorado Anschutz Medical Center. The most frequent species were Gram-positive including Enterococcus faecalis, Staphylococcus aureus, and Streptococcus agalactiae, also known as Group B Streptococcus (GBS). Most tissues had more than one species isolated with E. faecalis and GBS frequently occurring in polymicrobial infection with S. aureus. S. aureus was the best biofilm producing species with E. faecalis and GBS isolates exhibiting little to no biofilm formation. Antibiotic susceptibility varied amongst strains with high levels of penicillin resistance amongst S. aureus, clindamycin resistance amongst GBS and intermediate vancomycin resistance amongst E. faecalis. Finally, we utilized a murine model of diabetic wound infection and found that the presence of S. aureus led to significantly higher recovery of GBS and E. faecalis compared to mice challenged in mono-infection.
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  • 文章类型: Journal Article
    结节病是一种多器官炎性疾病,可在多达80%的病例中累及肝脏。很少,结节病可以表现为仅局限于肝脏的疾病。虽然大多数肝结节病患者在临床上是沉默的,某些病例可能有隐匿性发作,导致肝硬化和继发性并发症。这里,我们描述了3例孤立性肝结节病,以说明可能与这种情况相关的表现范围。在调查未分化肝病患者时,临床医生应警惕肝结节病是罪魁祸首。
    Sarcoidosis is a multi-organ inflammatory disease that can have hepatic involvement in up to 80% of cases. Rarely, sarcoidosis can manifest with only confined disease to the liver. While most patients with hepatic sarcoidosis are clinically silent, certain cases can have insidious onset leading to cirrhosis and secondary complications. Here, we describe three cases of isolated hepatic sarcoidosis to illustrate the range of presentations that may be associated with this condition. Clinicians should be vigilant in consideration of hepatic sarcoidosis as a culprit when investigating patients with undifferentiated liver disease.
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  • 文章类型: Journal Article
    胫骨关节固定术(TCA)可以通过内固定(髓内钉或钢板)实现,外固定,或组合。最佳方法的证据是有限的。本系统综述检查了这些不同方法的结果,以指导手术管理。
    使用“胫骨,\"\"脚踝,\"\"融合或关节固定术。“主要结果是工会。次要结果包括术后并发症的发生率,负重状态,翻修手术率,我们纳入了任何随访超过6个月的研究,其中包含我们的主要结局和至少1个次要结局.
    最初的搜索产生了164篇文章,其中9项研究共53例符合标准。大多数文章被排除在外,因为它们是非手术研究,或者不是关于孤立的TCA,而是用于胫骨关节固定术,更复杂的重建(例如,Charcot),病例报告,和/或不包括预定的结果度量。外固定术后TCA愈合率为86.2%,82.4%用于髓内钉固定,钢板固定占83.3%。一名患者接受了外固定和内固定的混合治疗,结果是不团结。术后并发症发生率为69.8%。
    关于孤立胫骨关节固定术的最佳手术方法的证据有限。外固定和内固定方法的愈合率相当。外固定有频繁的并发症和更具挑战性的术后方案。3D打印笼子和距骨置换等新技术可能成为一种有希望的替代方案,但需要进一步研究。
    UNASSIGNED: Tibiocalcaneal arthrodesis (TCA) can be achieved by internal fixation (intramedullary nail or plate), external fixation, or a combination. Evidence for the optimal approach is limited. This systematic review examines the outcomes of these different approaches to guide surgical management.
    UNASSIGNED: A MEDLINE and Oxford SOLO search was performed using \"tibiocalcaneal,\" \"ankle,\" \"fusion OR arthrodesis.\" The primary outcome was union. Secondary outcomes included rates of postoperative complications, weightbearing status, rates of revision surgery, and PROMs. We included any studies with follow-up greater than 6 months that contained our primary outcome and at least 1 secondary outcome.
    UNASSIGNED: The initial search yielded 164 articles, of which 9 studies totaling 53 cases met the criteria. The majority of articles were excluded because they were nonsurgical studies, or were not about isolated TCA but were for tibiotalocalcaneal arthrodesis, more complex reconstructions (eg, Charcot), case reports, and/or did not include the predetermined outcome measures.TCA union rate was 86.2% following external fixation, 82.4% for intramedullary nail fixation, and 83.3% for plate fixation. One patient underwent a hybrid of external and internal fixation, and the outcome was nonunion. The rate of complications following TCA was 69.8%.
    UNASSIGNED: There is limited evidence on the best operative approach for isolated tibiocalcaneal arthrodesis. Both external and internal fixation methods had comparable union rates. External fixation had frequent complications and a more challenging postoperative protocol. Novel techniques such as 3D-printed cages and talus replacement may become a promising alternative but require further investigation.
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  • 文章类型: Journal Article
    背景:肺动脉高压(PH)的血流动力学分类具有重要的临床意义。然而,只有少数超声心动图变量已用于对狗的PH进行血液动力学分类。
    目的:评估PH犬的超声心动图肺与左心房比值指数(ePLAR)。
    方法:46只PH概率中等到高的狗。
    方法:横断面研究。比较了毛细血管前PH[PrePH(n=24)]与毛细血管后PH[PostPH(n=22)]的狗之间的变量,并且使用t-,组合PH[CombPH(n=14)]与分离PH[IsoPH(n=8)],Mann-Whitney,皮尔森的志,或者费希尔的精确检验。受试者工作特征曲线和Youden指数用于确定最佳ePLAR截止值,以区分各组,使用组内相关系数(ICC)来确定测量的可靠性.
    结果:前PH组的平均值(SD)高于后PH组[0.36(0.13)对0.26(0.09),分别为;P=0.005]。CombPH的中位数(四分位距)ePLAR高于IsoPH亚组[0.29(0.24-0.38),vs.0.20(0.16-0.23),分别为;P=.001]。用于鉴定IsoPH的ePLAR的最佳截断值为<0.245[截止点AUC=0.86;灵敏度(95%置信区间[CI])=0.71(0.47-0.95);特异性(95%CI)=1(0.76-1)]。ICC分析表明具有高度的可靠性。
    结论:ePLAR可以被认为是一种有效的非侵入性变量,可以对狗的PH进行血液动力学分类,其中PH的概率为中等到高。ePLAR的评估可用于狗的PH的治疗管理。
    BACKGROUND: Hemodynamic classification of pulmonary hypertension (PH) has important clinical implications. However, only a few echocardiographic variables have been used to hemodynamically classify PH in dogs.
    OBJECTIVE: To evaluate the echocardiographic pulmonary to left atrial ratio index (ePLAR) in dogs with PH.
    METHODS: Forty-six dogs with intermediate to high probability of PH.
    METHODS: Cross-sectional study. Variables were compared between dogs with precapillary PH [PrePH (n = 24)] vs postcapillary PH [PostPH (n = 22)], and with combined PH [CombPH (n = 14)] vs isolated PH [IsoPH (n = 8)] using the t-, Mann-Whitney, Pearson\'s Chi, or Fisher\'s exact test. The receiver operating characteristic curve and Youden index were used to identify the optimal ePLAR cutoff value to differentiate among the groups, intraclass correlation coefficients (ICC) were used to determine the reliability of measurements.
    RESULTS: The mean (SD) ePLAR of the PrePH was higher than that of the PostPH group [0.36 (0.13) vs 0.26 (0.09), respectively; P = .005]. The median (interquartile range) ePLAR of the CombPH was higher than that of the IsoPH subgroup [0.29 (0.24-0.38), vs 0.20 (0.16-0.23), respectively; P = .001]. The best cutoff value of ePLAR for identifying IsoPH was <0.245 [AUC at cutoff point = 0.86; sensitivity (95% confidence interval [CI]) = 0.71 (0.47-0.95); specificity (95% CI) = 1 (0.76-1)]. The ICC analysis indicated a high degree of reliability.
    CONCLUSIONS: ePLAR can be considered a valid noninvasive variable to hemodynamically classify PH in dogs with an intermediate to high probability of PH. Assessment of ePLAR can be useful in the therapeutic management of PH in dogs.
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  • 文章类型: Clinical Study
    背景:孤立性脾静脉血栓形成(iSVT)是胰腺疾病的常见并发症。虽然患者仍然无症状,如果没有再通,则有发生左侧门脉高压和随后胃底静脉曲张出血的风险。iSVT治疗有很大差异,甚至在单一中心内。我们报告了三级转诊肝胆胰(HPB)单位的iSVT结果,包括抗凝对再通率和随后的静脉曲张出血风险的影响。
    方法:一项回顾性队列研究,包括2011年至2019年间来自两个机构的在腹部和骨盆的对比增强CT扫描中诊断为iSVT的所有患者。排除诊断时同时存在SVT和门静脉血栓形成以及继发于恶性肿瘤的孤立性脾静脉血栓形成的患者。抗凝治疗的结果,再通率,使用CT扫描腹部和骨盆并对比检查出血和门静脉血栓形成的风险。
    结果:纳入98例iSVT患者,其中39例患者接受抗凝治疗(40%)。iSVT的最常见原因是急性胰腺炎,n=88(90%)。抗凝组的再通率为46%,而未接受抗凝治疗的患者为15%(p=0.0008,OR=4.7,95%CI1.775至11.72)。接受抗凝治疗的患者中,上腹部血管侧支(CT扫描血管造影显示)明显较少(p=0.03,OR=0.4,95%CI0.1736至0.9288)。上消化道静脉曲张相关出血的总发生率为3%(n=3/98),与抗凝治疗无关。其中两名患者接受了治疗性抗凝治疗。
    结论:目前的数据支持治疗性抗凝与脾静脉再通率的显著增加相关,随后放射学左侧门静脉高压症的减少。然而,所有患者发生静脉曲张破裂出血的风险都很低,无论是否抗凝治疗.这项回顾性研究的结果值得在大规模随机临床试验中进一步研究。
    BACKGROUND: Isolated splenic vein thrombosis (iSVT) is a common complication of pancreatic disease. Whilst patients remain asymptomatic, there is a risk of sinistral portal hypertension and subsequent bleeding from gastric varices if recanalisation does not occur. There is wide variation of iSVT treatment, even within single centres. We report outcomes of iSVT from tertiary referral hepatobiliary and pancreatic (HPB) units including the impact of anticoagulation on recanalisation rates and subsequent variceal bleeding risk.
    METHODS: A retrospective cohort study including all patients diagnosed with iSVT on contrast-enhanced CT scan abdomen and pelvis between 2011 and 2019 from two institutions. Patients with both SVT and portal vein thrombosis at diagnosis and isolated splenic vein thrombosis secondary to malignancy were excluded. The outcomes of anticoagulation, recanalisation rates, risk of bleeding and progression to portal vein thrombosis were examined using CT scan abdomen and pelvis with contrast.
    RESULTS: Ninety-eight patients with iSVT were included, of which 39 patients received anticoagulation (40%). The most common cause of iSVT was acute pancreatitis n = 88 (90%). The recanalisation rate in the anticoagulation group was 46% vs 15% in patients receiving no anticoagulation (p = 0.0008, OR = 4.7, 95% CI 1.775 to 11.72). Upper abdominal vascular collaterals (demonstrated on CT scan angiography) were significantly less amongst patients who received anticoagulation treatment (p = 0.03, OR = 0.4, 95% CI 0.1736 to 0.9288). The overall rate of upper GI variceal-related bleeding was 3% (n = 3/98) and it was independent of anticoagulation treatment. Two of the patients received therapeutic anticoagulation.
    CONCLUSIONS: The current data supports that therapeutic anticoagulation is associated with a statistically significant increase in recanalisation rates of the splenic vein, with a subsequent reduction in radiological left-sided portal hypertension. However, all patients had a very low risk of variceal bleeding regardless of anticoagulation. The findings from this retrospective study should merit further investigation in large-scale randomised clinical trials.
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