背景:COVID-19与各种心血管和代谢紊乱之间的相互关系一直是研究的关键领域。越来越需要了解心血管疾病(CVD)和代谢紊乱等合并症如何影响COVID-19的风险和严重程度。
目的:本研究的目的是系统分析COVID-19与心血管和代谢紊乱的关系。重点是合并症,检查心血管疾病的作用,如栓塞,血栓形成,高血压,心力衰竭,以及代谢紊乱,如葡萄糖和铁代谢紊乱。
方法:我们的研究涉及在PubMed中对2000年至2022年发表的文献进行系统搜索。我们建立了2个数据库:一个是COVID-19相关文章,另一个是CVD相关文章,确保所有人都经过同行评审。在数据分析方面,应用统计学方法比较了2个数据库之间MeSH(医学主题词)术语的频率和相关性.这包括分析这些术语使用的差异和比率,并采用统计检验来确定它们与COVID-19研究背景下关键CVD的相关性。
结果:该研究表明,“心血管疾病”和“营养和代谢疾病”与COVID-19合并症研究中的1级医学主题词高度相关。第2级和第3级的详细分析显示,“血管疾病”和“心脏病”是CVD下的主要描述词。重要的是,“葡萄糖代谢紊乱”经常与COVID-19并发症如栓塞相关,血栓形成,和心力衰竭。此外,缺铁(ID)在COVID-19和CVD文章之间的发生率显着不同,强调其在COVID-19合并症背景下的重要性。统计分析强调了这些差异,强调COVID-19研究中葡萄糖和铁代谢紊乱的重要性。
结论:这项工作为未来的研究奠定了基础,该研究利用基于知识的方法来阐明这些条件之间的复杂关系,旨在面对持续的大流行挑战,制定更有效的医疗保健战略和干预措施。
BACKGROUND: The interrelation between COVID-19 and various cardiovascular and metabolic disorders has been a critical area of study. There is a growing need to understand how comorbidities such as cardiovascular diseases (CVDs) and metabolic disorders affect the risk and severity of COVID-19.
OBJECTIVE: The objective of this study is to systematically analyze the association between COVID-19 and cardiovascular and metabolic disorders. The focus is on comorbidity, examining the roles of CVDs such as embolism, thrombosis, hypertension, and heart failure, as well as metabolic disorders such as disorders of glucose and iron metabolism.
METHODS: Our study involved a systematic search in PubMed for literature published from 2000 to 2022. We established 2 databases: one for COVID-19-related articles and another for CVD-related articles, ensuring all were peer-reviewed. In terms of data analysis, statistical methods were applied to compare the frequency and relevance of MeSH (Medical Subject Headings) terms between the 2 databases. This involved analyzing the differences and ratios in the usage of these terms and employing statistical tests to determine their significance in relation to key CVDs within the COVID-19 research context.
RESULTS: The study revealed that \"Cardiovascular Diseases\" and \"Nutritional and Metabolic Diseases\" were highly relevant as level 1 Medical Subject Headings descriptors in COVID-19 comorbidity research. Detailed analysis at level 2 and level 3 showed \"Vascular Disease\" and \"Heart Disease\" as prominent descriptors under CVDs. Significantly, \"Glucose Metabolism Disorders\" were frequently associated with COVID-19 comorbidities such as embolism, thrombosis, and heart failure. Furthermore, iron deficiency (ID) was notably different in its occurrence between COVID-19 and CVD articles, underlining its significance in the context of COVID-19 comorbidities. Statistical analysis underscored these differences, highlighting the importance of both glucose and iron metabolism disorders in COVID-19 research.
CONCLUSIONS: This work lays the foundation for future research that utilizes a knowledge-based approach to elucidate the intricate relationships between these conditions, aiming to develop more effective health care strategies and interventions in the face of ongoing pandemic challenges.