■疲劳是最常见的症状之一,在全球范围内增加,没有针对疲劳的特定药物。伊朗传统医学(ITM)或者波斯医学,是发现疾病及其症状的天然药物的可靠来源。MyrtuscommunisL.(默特尔),MalusdomesticaBorkh.(苹果),和香菇(L.)合并。&L.M.Perry(丁香)已被用作ITM的脑和心脏补品。基于ITM,心脏补品通过增强心脏功能和增加组织的血流量来减少疲劳。这些植物,尤其是桃金娘浆果,已被用作减少精神疲劳的有效活跃剂。
■这项研究旨在研究这些植物的水提取物对慢性睡眠剥夺动物模型中的负重强迫游泳(WLFS)测试和三种剂量的桃金娘水提取物的影响。
■对五组大鼠(n=6)进行了评估:假,control,苹果处理,丁香处理,和桃金娘治疗组。治疗28天后,进行了WLFS测试,记录游泳时间。随后,慢性睡眠剥夺21天可引起大鼠中枢疲劳。评估了五组大鼠(n=6):假,控制(睡眠不足,收到水),和三个睡眠不足+治疗组,接受桃金娘水提取物(350、700和1000mg/kg)。在第20天进行空场测试,在第21天进行WLFS测试。
■桃金娘浆果显著增加了葡萄糖,乳酸脱氢酶(LDH)水平降低,增加游泳时间。慢性睡眠剥夺引起的疲劳增加丙二醛(MDA),肿瘤坏死因子-α(TNF-α),白细胞介素-1β(IL-1β),和LDH,而减少超氧化物歧化酶(SOD),葡萄糖,游泳时间在所有治疗组中,SOD水平和游泳时间增加,而MDA,IL-1β,TNF-α水平明显下降。仅1000mg/kg剂量显著降低LDH水平(P<0.001)。该处理显著提高了开场试验中移动的速度和总距离。
■根据结果,桃金娘浆果减少了两种动物模型的疲劳,可能是由于它的酚类化合物,黄酮类化合物,和多糖。
UNASSIGNED: Fatigue is one of the most prevalent symptoms, increasing worldwide with no specific medication for fatigue. Iranian traditional medicine (ITM), or Persian medicine, is a reliable source for discovering natural medicine for diseases and their symptoms. Myrtus communis L. (Myrtle), Malus domestica Borkh. (Apple), and Syzygium aromaticum (L.) Merr. & L. M. Perry (Clove) have been utilized as brain and heart tonics in ITM. Based on ITM, cardiac tonics decrease fatigue by enhancing heart function and increasing blood flow to tissues. These plants, particularly myrtle berries, have been utilized as potent enlivening agents that reduce mental fatigue.
UNASSIGNED: This study aims to investigate the effects of aqueous extracts of these plants on weight-loaded forced swimming (WLFS) tests and three doses of aqueous myrtle extract in an animal model of chronic sleep deprivation-induced fatigue.
UNASSIGNED: Five groups of rats (n = 6) were evaluated: Sham, control, apple-treated, clove-treated, and myrtle-treated groups. After 28 days of treatment, the WLFS test was performed, and swimming time was recorded. Subsequently, central fatigue was induced in rats by chronic sleep deprivation for 21 days. Five groups of rats (n = 6) were evaluated: Sham, control (sleep-deprived, which received water), and three sleep-deprived + treatment groups, which received aqueous myrtle extract (350, 700, and 1000 mg/kg). An open field test on the 20th day and a WLFS test on the 21st day were performed.
UNASSIGNED: The myrtle berries significantly increased glucose, reduced lactate dehydrogenase (LDH) levels, and enhanced swimming time. Fatigue caused by chronic sleep deprivation increased malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and LDH while decreased superoxide dismutase (SOD), glucose, and swimming time. In all treatment groups, SOD levels and swimming time were increased, whereas MDA, IL-1β, and TNF-α levels were decreased significantly. Only the 1000 mg/kg dose significantly reduced LDH levels (P < 0.001). The treatment significantly improved the velocity and the total distance moved in the open-field test.
UNASSIGNED: According to the results, the myrtle berries reduced fatigue in two animal models, probably due to its phenolic compounds, flavonoids, and polysaccharides.