双(吲哚基)甲烷是一类主要的杂环,具有相当大的技术和生物应用前景,也是荧光活性的。考虑到各种合成技术的大量工作,这项研究的目的是测量与不同类型的双(吲哚基)甲烷(BIM)衍生物相关的研究的先前和当前状态。目前,研究的重点是制定可靠的绿色合成策略,可持续和环境友好的合成工艺。本文献描述了使用常规反应程序从合适的前体开始形成BIM部分。以及微波介导的反应,超声波,有机催化剂,过渡金属催化剂,无金属离子液体催化剂,和其他环境友好的反应方案。当前的评论讨论了在过去的几十年中,双(吲哚基)甲烷及其类似物的不同环保合成路线的爆炸性发展。此外,这项研究包括生物活性,如抗菌,抗癌,抗炎,等。,BIM衍生物,近年来一直在调查。
Bis(indolyl)Methanes are a major class of heterocycles with considerable promise for technological and biological applications and being fluorescent active as well. Considering the extensive quantity of work on various synthetic techniques, the objective of this study is to measure the previous and current status of research studies related to different types of Bis(indolyl)methane (BIM) derivatives. Currently, research is focused on developing green synthetic strategies for dependable, sustainable and environmentally friendly synthetic processes. The present literature describes the formation of BIM moieties starting from suitable precursors using conventional reaction procedures, as well as reactions mediated by microwaves, ultrasounds, organocatalysts, transition metal catalysts, metal-free ionic liquid catalysts, and other environmentally friendly reaction protocols. The current review discusses the explosive development of different environmentally friendly synthesis routes for bis(indolyl)methane and its analogues during the past few decades. Moreover, this study includes the biological activities such as antibacterial, anticancer, anti-inflammatory, etc., of BIM derivatives, which have been investigated in recent years.