■据推测,异常的感觉过程有助于功能性神经系统疾病的病理生理学,尽管调查结果不一致。这里,我们利用功能磁共振成像(fMRI)检查了功能性运动障碍(FMD)中感知式注意-意识焦点和身体感觉意识的神经相关性.
■我们使用逐体素分析来比较13名患有多动性口蹄疫的成年人和13名健康对照(HC)在一项需要注意不同身体感觉和外在感受刺激的任务期间的血氧水平依赖性反应。此外,我们检查了组间自我报告的相互感觉测量值的差异,并评估了它们与神经活动的关系.
■互感状况(心跳,胃和“身体”,指示FMD参与者受影响的身体部位或肢体的感觉)激活了涉及前突的网络,后扣带皮质(PCC)和尾状核(CN)两侧,和右前脑岛(aINS)(p<0.05,更正)。大脑活动的群体差异主要是由疾病相关的感受信号的处理驱动的,在FMD组中,与监测胃内感觉相比,它与更广泛的神经激活有关,而在心脏间感觉期间未检测到组差异。在PCC中发现了FMD受试者和HCs之间基于相互感觉焦点(身体与心跳和胃)的差异,CN,角回,丘脑,和中岛(p<0.05,校正)。
■这是,根据我们的知识,第一项研究表明,口蹄疫与参与监测身体状态的区域的异常交互感受处理有关,注意力集中,和稳态推理。
UNASSIGNED: Aberrant interoceptive processing has been hypothesized to contribute to the pathophysiology of functional neurological disorder, although findings have been inconsistent. Here, we utilized functional magnetic resonance imaging (fMRI) to examine neural correlates of interoceptive attention - the conscious focus and awareness of bodily sensations - in functional movement disorder (FMD).
UNASSIGNED: We used voxelwise analyses to compare blood oxygenation level-dependent responses between 13 adults with hyperkinetic FMD and 13 healthy controls (HCs) during a task requiring attention to different bodily sensations and to an exteroceptive stimulus. Additionally, we examined between-group differences in self-reported measures of interoception and evaluated their relationship with neural activity.
UNASSIGNED: Interoceptive conditions (heartbeat, stomach and \'body\', indicating sensations from the body part or limb affected in FMD participants) activated a network involving the precuneus, the posterior cingulate cortex (PCC) and caudate nucleus (CN) bilaterally, and the right anterior
insula (aINS) (p <0.05, corrected). Group differences in brain activity were mainly driven by processing of disease-related interoceptive signals, which in the FMD group was associated with a broader neural activation than monitoring gastric interoception, while no group differences were detected during cardiac interoception. Differences based on interoceptive focus (body vs heartbeat and stomach) between FMD subjects and HCs were found in PCC, CN, angular gyrus, thalamus, and in the mid-
insula (p <0.05, corrected).
UNASSIGNED: This is, to our knowledge, the first study showing that FMD is associated with abnormal interoceptive processing in regions involved in monitoring body state, attentional focus, and homeostatic inference.