A型肉毒杆菌毒素(BoNT-A)和透明质酸(HA)皮肤填充剂越来越多地用于牙科治疗和美学目的。然而,缺乏对其临床应用和牙科适应症的全面综合。本系统综述旨在分析BoNT-A和HA真皮填充剂在牙科的临床应用及适应证。提供对其功效的见解,安全概况,和限制。
■在PubMed/MEDLINE数据库中进行了系统搜索,以确定2018年至2024年之间发表的相关研究。与BoNT-A相关的医学主题词(MeSH)术语和关键词,HA真皮填充物,牙科,临床应用,并使用了适应症。研究选择标准包括随机对照试验(RCT)和非RCT,涉及任何年龄组的人类参与者。数据提取和综合遵循既定准则,注重学习特点,参与者人口统计,干预细节,结果衡量标准,以及与BoNT-A和HA真皮填充剂在牙科临床应用相关的关键发现。
■跨电子数据库和灰色文献的系统搜索确定了857条记录,另有73人来自手工搜索。筛选标题和摘要后,542条记录被排除在外,留下374份全文出版物供评估。最终,包括12个RCT和13个非RCT。系统审查涵盖了不同的地理位置:巴西,意大利,西班牙,叙利亚,印度,埃及,韩国,还有荷兰,涉及14至143名参与者的样本量。这篇综述综合了HA在各个领域的疗效发现,包括骨修复,牙龈炎的管理,颞下颌关节病,术后消肿,牙周缺损治疗,下巴和检查投影和嘴唇增加。BoNT-A在治疗口面部疼痛方面表现出有希望的疗效,软糖微笑治疗和下三分之一肌肉的神经调节。不同研究的安全状况各不相同,一些人报告不良反应最小,而另一些人则指出剂量相关问题。
■BoNT-A和HA真皮填充剂在牙科领域提供了广泛的临床应用,从治疗干预到美学增强。尽管疗效有希望,在将这些干预措施纳入临床实践时,仔细考虑和监测安全性结局至关重要.需要进一步研究解决方法上的局限性和安全性问题,以优化其利用率并改善牙科患者护理。
UNASSIGNED: Botulinum toxin type A (BoNT-A) and hyaluronic acid (HA) dermal fillers are increasingly utilized in dentistry for therapeutic and aesthetic purposes. However, a comprehensive synthesis of their clinical applications and
indications in dentistry is lacking. This systematic review aimed to analyze the clinical application and
indications of BoNT-A and HA dermal fillers in dentistry, providing insights into their efficacy, safety profiles, and limitations.
UNASSIGNED: A systematic search was conducted in PubMed/MEDLINE databases to identify relevant studies published between 2018 and 2024. Medical Subject Headings (MeSH) terms and keywords related to BoNT-A, HA dermal fillers, dentistry, clinical applications, and
indications were used. Study selection criteria included randomized controlled trials (RCTs) and non-RCTs involving human participants of any age group. Data extraction and synthesis followed established guidelines, focusing on study characteristics, participant demographics, intervention details, outcome measures, and key findings related to BoNT-A and HA dermal fillers\' clinical application in dentistry.
UNASSIGNED: Systematic searches across electronic databases and grey literature identified 857 records, with an additional 73 from hand searches. After screening titles and abstracts, 542 records were excluded, leaving 374 full-text publications for evaluation. Ultimately, 12 RCTs and 13 non-RCTs were included. The systematic review encompassed diverse geographic locations: Brazil, Italy, Spain, Syria, India, Egypt, Korea, and the Netherlands, involving samples sizes ranging from 14 to 143 participants. The review synthesized findings on HA\'s efficacy in various areas, including bone repair, gingivitis management, temporomandibular joint disorders, postoperative swelling reduction, periodontal defect treatment, chin and check projection and lips augmentation. BoNT-A exhibited promising efficacy in managing orofacial pain conditions, gummy smile treatment and neuromodulation of the lower third muscles. Safety profiles varied among studies, with some reporting minimal adverse effects while others noted dose-related concerns.
UNASSIGNED: BoNT-A and HA dermal fillers offer a wide array of clinical applications in dentistry, ranging from therapeutic interventions to aesthetic enhancements. Despite promising efficacy, careful consideration and monitoring of safety outcomes are essential when integrating these interventions into clinical practice. Further research addressing methodological limitations and safety concerns is warranted to optimize their utilization and improve patient care in dentistry.