文献显示,基于脂肪组织过量的伴随存在,肌肉减少症通常与不同的表型一起发生(即,肌肉减少性肥胖,SO),或骨量减少/骨质疏松症(骨量减少症,操作系统),或者两个条件的组合,所谓的骨营养不良性肥胖(OSO)。这项研究旨在评估肌肉减少症表型的患病率(SO,操作系统,OSO),他们的相关危险因素及其对居住在意大利北部的门诊病人和住院病人的健康影响。年龄≥18岁的男性和女性受试者被纳入研究。收集血液样本以测量目标血液制造者。全面的人体测量学临床评估(身高,体重,身体质量指数,BMI和双能X线吸收法,DXA)进行测量,骨头,脂肪,和肌肉状态。共有1510人参加了这项研究(女性,n=1100;72.85%)。肌肉减少症是最普遍的表型(17%),其次是骨量减少症(14.7%)和少肌症性肥胖。只有1.9%的样品受到OSO的影响。根据Logistic回归分析,肌肉减少症与年龄有关,红细胞沉降率(ESR),C反应蛋白(CRP)(阳性)和BMI,铁(Fe),总胆固醇,白蛋白(%),白蛋白(g),和γ蛋白(负)。肌肉减少性肥胖与年龄有关,铁蛋白,ESR,CRP(正)和BMI,Fe,和白蛋白(%)(负)。骨质减少症与年龄有关,ESR(正)和BMI,总胆固醇,白蛋白(%),白蛋白(g),和Ca(负)。骨性肥胖与血糖和γ-谷氨酰转移酶(gGT)(正)相关。根据随机森林分析,较高的BMI是肌少症最重要的保护因素,用于减少肌少症的肥胖(与铁一起)和骨减少症(与白蛋白一起)。此外,骨量减少性肥胖与GgT和血糖呈正相关。获得这些信息的可能性,尤其是在年轻人口中,可以帮助防止这类疾病的发作和最适合病人的需要,根据精准医学的方法。
The literature shows how sarcopenia often occurs along with different phenotypes based either on the concomitant presence of adipose tissue excess (i.e., sarcopenic obesity, SO), or osteopenia/osteoporosis (osteosarcopenia, OS), or the combination of the two conditions, so-called osteosarcopenic obesity (OSO). This research aimed to assess the prevalence of sarcopenia phenotypes (SO, OS, OSO), their associated risk factors and their health impact in a population of out- and inpatients living in the North of Italy. Male and female subjects aged ≥18 years were enrolled for the study. A blood sample was collected to measure targeted blood makers. A comprehensive anthropometric clinical assessment (height, weight, Body Mass Index, BMI and Dual Energy X-ray Absorptiometry, DXA) was performed to measure ponderal, bone, fat, and muscle status. A total of 1510 individuals participated to the study (females, n = 1100; 72.85%). Sarcopenia was the most prevalent phenotype (17%), followed by osteosarcopenia (14.7%) and sarcopenic obesity. Only 1.9% of the sample was affected by OSO. According to logistic regression analysis, sarcopenia was associated with age, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) (positively) and BMI, Iron (Fe), Total Cholesterol, albumin (%), albumin (g), and gamma proteins (negatively). Sarcopenic obesity was associated with age, ferritin, ESR, CRP (positively) and BMI, Fe, and albumin (%) (negatively). Osteosarcopenia was associated with age, ESR (positively) and BMI, Total Cholesterol, albumin (%), albumin (g), and Ca (negatively). Osteosarcopenic obesity was associated with glycemia and gamma-glutamyl transferase (gGT) (positively). According to random forest analysis, a higher BMI was the most important protective factor for sarcopenia, for sarcopenic obesity (along with Iron) and for osteosarcopenia (along with albumin). Moreover, osteosarcopenic obesity was positively associated with GgT and glycaemia. The possibility of gaining such information, especially in the younger population, could help to prevent the onset of such diseases and best fit the patient\'s needs, according to a precision-medicine approach.