■米糠阿拉伯木聚糖化合物(RBAC)是一种具有抗癌特性的天然免疫调节剂。
■这项研究严格评估了有关RBAC生物学途径及其对癌症治疗的影响的现有证据。
■对范围审查的二次分析包括评估RBAC对健康或恶性细胞的机制的研究,动物模型,或人类用于癌症预防或治疗。对生存率和生活质量结局的随机对照试验数据进行荟萃分析。
■证据综合基于38篇文章。RBAC通过促进癌症患者的细胞凋亡和恢复免疫功能来增强炎症和细胞毒性反应以阻断肿瘤发生而表现出抗肿瘤特性。RBAC通过上调药物转运与化疗剂协同作用。在临床试验中,RBAC联合化疗栓塞治疗肝癌疗效改善,降低复发率,和延长生存期。RBAC还增强内源性抗氧化系统以防止氧化应激并防止辐射副作用。此外,RBAC具有化学保护作用。动物和人类已经表现出降低的化疗毒性和副作用。Meta分析表明,RBAC治疗在第一年增加了4.02倍(95%CI:1.67,9.69),在第二年增加了2.89倍(95%CI:1.56,5.35)。
■RBAC是一种天然产品,在癌症治疗中具有巨大潜力。需要额外的研究来表征,量化、并标准化RBAC中负责抗癌作用的活性成分。更精心设计,需要大规模的临床试验来进一步证实治疗效果。
UNASSIGNED: Rice bran arabinoxylan compound (RBAC) is a natural
immunomodulator with anticancer properties.
UNASSIGNED: This study critically evaluates the available evidence on the biological pathways of RBAC and its effects on cancer treatment.
UNASSIGNED: This secondary analysis of a scoping review includes studies evaluating the mechanisms of RBAC on healthy or malignant cells, animal models, or humans for cancer prevention or treatment. Data from randomized controlled trials on survival and quality of life outcomes were subjectd to meta analysis.
UNASSIGNED: The evidence synthesis was based on 38 articles. RBAC exhibited antitumor properties by promoting apoptosis and restoring immune function in cancer patients to enhance inflammatory and cytotoxic responses to block tumorigenesis. RBAC works synergistically with chemotherapeutic agents by upregulating drug transport. In a clinical trial, combining RBAC with chemoembolization in treating liver cancer showed improved response, reduced recurrence rates, and prolonged survival. RBAC also augments the endogenous antioxidant system to prevent oxidative stress and protect against radiation side effects. In addition, RBAC has chemoprotective effects. Animals and humans have exhibited reduced toxicity and side effects from chemotherapy. Meta analysis indicates that RBAC treatment increases the survival odds by 4.02-times (95% CI: 1.67, 9.69) in the first year and 2.89-times (95% CI: 1.56, 5.35) in the second year.
UNASSIGNED: RBAC is a natural product with immense potential in cancer treatment. Additional research is needed to characterize, quantify, and standardize the active ingredients in RBAC responsible for the anticancer effects. More well-designed, large-scale clinical trials are required to substantiate the treatment efficacies further.