■使用多种成像方式研究年龄相关性黄斑变性患者网状假性玻璃疣(RPD)的存在和患病率,并比较这些方式在检测RPD中的敏感性和特异性。
■对总共198名连续患者的图像进行了前瞻性分析。彩色眼底摄影,无红色成像,谱域光学相干层析成像(SD-OCT),红外和蓝色反射(BR)成像,眼底自发荧光(FAF),增强深度成像OCT(EDI-OCT),进行荧光素眼底血管造影(FFA)和吲哚菁绿血管造影。在使用的至少两种成像方法中存在相关发现的情况下诊断RPD。
■在149只眼中检测到RPD(37.6%)。在RPD的检测中,彩色眼底摄影,无红色摄影,SD-OCT,红外线,FAF,BR,FFA成像的灵敏度值为50%,57.7%,91.6%,95%,74.6%,65.7%,和28.2%和99.6%的特异性值,100%,98.4%,94.6%,100%,99.6%,和69.8%,分别。
■红外成像具有最高的灵敏度。SD-OCT联合红外成像是检测RPD最灵敏的成像技术。FAF的高特异性,无红色,和BR成像可能有助于确认RPD的诊断。
To investigate the presence and prevalence of reticular pseudodrusen (RPD) in patients with age-related macular degeneration using multiple imaging modalities and to compare the sensitivity and specificity of these modalities in the detection of RPD.
Images from a total of 198 consecutive patients were analyzed prospectively. Color fundus photography, red-free imaging, spectral domain optical coherence tomography (SD-OCT), infrared and blue reflectance (BR) imaging, fundus autofluorescence (FAF), enhanced-depth imaging OCT (EDI-OCT), fundus fluorescein angiography (FFA) and indocyanine green angiography were performed. RPD was diagnosed in the presence of relevant findings in at least two of the imaging methods used.
RPD were detected in 149 eyes (37.6%). In the detection of RPD, color fundus photography, red-free photography, SD-OCT, infrared, FAF, BR, and FFA imaging had sensitivity values of 50%, 57.7%, 91.6%, 95%, 74.6%, 65.7%, and 28.2% and specificity values of 99.6%, 100%, 98.4%, 94.6%, 100%, 99.6%, and 69.8%, respectively.
Infrared imaging had the highest sensitivity. SD-OCT combined with infrared imaging was the most sensitive imaging technique for detecting RPD. The high specificity of FAF, red-free, and BR imaging may be useful to confirm a diagnosis of RPD.