背景:慢性胰腺炎(CP)在英国可卡犬(ECS)中很常见。它在组织学上与人类的IgG4相关疾病(IgG4-RD)相似,并以导管破坏为特征。小叶间纤维化,和致密的导管周围和静脉周围淋巴细胞聚集体。然而,ECS中CP的临床表现以前没有描述过.
目的:表征一组ECS中CP的临床表现,包括与人类IgG4-RD的异同。
方法:104个带有CP的ECS和44个客户拥有的无CP的控制ECS(健康和患病的对照)。
方法:受影响的狗根据诊断CP的方法分为2组。搜查了案件记录以寻找信号,临床,和临床病理发现,和干燥性角膜结膜炎(KCS)的证据,蛋白尿,其他免疫介导的疾病,和肛门关节炎.
结果:涉及其他器官是常见的。受影响的ECS呈现高频率的KCS(n=49),蛋白尿(n=47),肛门腺病(n=36),特应性(n=21),和其他免疫介导的疾病(n=16)。那些有某种颜色的头发外套,尤其是蓝罗,与CP有很强的联系,表明该品种的皮毛颜色和自身免疫状况之间存在联系。
结论:患有CP的英国可卡犬与患有IgG4-RD和其他器官共同受累的人类表现出临床相似性。临床医生应评估受影响的可卡猎犬的蛋白尿,干燥性角膜结膜炎,和其他潜在的免疫介导的疾病。
BACKGROUND: Chronic pancreatitis (CP) is common in English cocker spaniels (ECS). It is histologically similar to IgG4-related disease (IgG4-RD) in humans and is characterized by duct destruction, interlobular fibrosis, and dense periductular and perivenous lymphocytic aggregates. However, the clinical manifestations of CP in ECS have not been previously described.
OBJECTIVE: Characterize the clinical manifestations of CP in a group of ECS, including similarities and differences to IgG4-RD in humans.
METHODS: One-hundred four ECS with CP and 44 client owned control ECS without CP (both healthy and diseased controls).
METHODS: Affected dogs were divided into 2 groups according to the methods used to diagnose CP. Case records were searched for signalment, clinical, and clinicopathological findings, and evidence of keratoconjunctivitis sicca (KCS), proteinuria, other immune-mediated diseases, and anal sacculitis.
RESULTS: Involvement of other organs was common. Affected ECS presented with a high frequency of KCS (n = 49), proteinuria (n = 47), anal gland disease (n = 36), atopy (n = 21), and other immune-mediated diseases (n = 16). Those with parti-color hair coats, particularly blue roan, had a strong association with CP, suggesting a link between coat color and autoimmune conditions in this breed.
CONCLUSIONS: English cocker spaniels with CP show clinical similarities to humans with IgG4-RD and common involvement of other organs. Clinicians should evaluate affected Cocker Spaniels for proteinuria, keratoconjunctivitis sicca, and other potential immune-mediated diseases.