血管紧张素转换酶(ACE)与心脏代谢危险因素和动脉粥样硬化密切相关。本研究旨在探讨ACE基因的插入/缺失(I/D)变异是否影响心脏代谢危险因素。早发冠状动脉疾病(PCAD),和冠状动脉病变的严重程度。PubMed,科克伦图书馆,中央,CINAHL,和ClinicalTrials.gov被搜索到2023年12月22日。94,270人被纳入分析。DD基因型的携带者有较高的甘油三酯(TG)水平,总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),收缩压(SBP),舒张压(DBP),体重指数(BMI),和腰围(WC)比II或ID基因型的携带者。此外,DD基因型携带者是PCAD和多血管病变的高危人群。ACEI/D变体对血脂水平的影响在美国个体中显着,但在男性个体中则更强。相比之下,ACEI/D变体对PCAD和冠状动脉病变严重程度的影响在白种人个体中主要显著.这项研究表明,ACEI/D变体对心脏代谢危险因素有轻微但显著的影响,PCAD,和冠状动脉病变的严重程度。血管紧张素转换酶抑制剂(ACEI)可能使ACEDD基因型的高危人群受益,以预防PCAD和多血管病变。PROSPERO注册号:CRD42023426732。
Angiotensin-converting enzyme (ACE) is closely related to cardiometabolic risk factors and atherosclerosis. This study aims to investigate whether the insertion/deletion (I/D) variant of ACE gene impacts cardiometabolic risk factors, premature coronary artery disease (PCAD), and severity of coronary lesions. PubMed, Cochrane Library, Central, CINAHL, and ClinicalTrials.gov were searched until December 22, 2023. 94,270 individuals were included for the analysis. Carriers of DD genotype had higher levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), and waist circumference (WC) than carriers of II or ID genotypes. In addition, carriers of DD genotype were at high risk of PCAD and multiple vessel lesions. The impacts of ACE I/D variant on lipid levels were significant in American individuals but stronger in male individuals. In contrast, the impacts of ACE I/D variant on PCAD and severity of coronary lesions were primarily significant in Caucasian individuals. This study indicates that the ACE I/D variant has a slight but significant impact on cardiometabolic risk factors, PCAD, and severity of coronary lesions. Angiotensin-converting enzyme inhibitors (ACEI) may benefit high-risk populations with ACE DD genotype to prevent PCAD and multiple vessel lesions.PROSPERO registration number: CRD42023426732.