全球范围内胃癌的死亡率仍然很高。免疫球蛋白样结构域含受体1(ILDR1)属于一个进化保守的蛋白质家族,对胃癌中的这个基因知之甚少。在本文中,我们使用公开数据库分析了ILDR1在胃癌中的表达及其与临床结局的关系.ONCOMINE,GEPIA2,UALCAN,Kaplan-Meier绘图仪,cBioPortal,GeneMANIA和LinkedOmics数据库用于分析表达,预后值,胃癌中ILDR1的突变和功能网络。我们观察到ILDR1在胃癌中比正常组织中高表达。在基于癌症分期的亚组分析中,胃癌患者的ILDR1表达明显高于正常对照组,病人的种族,性别,年龄,肿瘤分级,幽门螺杆菌感染,组织学亚型,淋巴结转移状态。生存分析显示ILDR1表达上调与不良预后显著相关。使用cBioPortal分析ILDR1的基因组改变,使用GeneMANIA和共表达的基因构建蛋白质-蛋白质相互作用(PPI)网络,基因本体论,和ILDR1的途径是使用LinkedOmics网络工具确定的。ILDR1在胃癌组织和正常组织中的表达存在显著差异,因此,可能是一个有希望的胃癌预后的生物标志物。
The worldwide mortality rate of gastric cancer worldwide remains high. Immunoglobulin-like domain containing receptor 1 (
ILDR1) belongs to an evolutionarily conserved protein family, and little is known about this gene in gastric cancer. In this paper, we analyzed the expression of
ILDR1 and its relationship with clinical outcomes in gastric cancer using publicly available databases. ONCOMINE, GEPIA2, UALCAN, Kaplan-Meier Plotter, cBioPortal, GeneMANIA and LinkedOmics databases were used to analyze the expression, prognostic values, mutations and functional networks of ILDR1 in gastric cancer. We observed that
ILDR1 was overexpressed in gastric cancer than in normal tissues.
ILDR1 expression was significantly higher in patients with gastric cancer than in normal controls during subgroup analysis based on cancer stage, patient\'s race, sex, age, tumor grade, H. pylori infection, histological subtype, and nodal metastasis status. Survival analysis showed that upregulation of
ILDR1 expression was significantly associated with poor prognosis. Genomic alterations in ILDR1 were analyzed using cBioPortal, protein-protein interaction (PPI) networks were constructed using GeneMANIA and the co-expressed genes, gene ontology, and pathways of ILDR1 were determined using the LinkedOmics web tool. ILDR1 showed significant differences in expression between gastric cancer and normal tissues and, thus, may be a promising prognostic biomarker for gastric cancer.