目的：评估使用OculusKeratograph5M（K5M）和SBMSistemiIDRA（IDRA）进行干眼测量的可重复性和一致性。
方法：共纳入108名参与者，评估108只眼。使用K5M和IDRA（随机分配顺序）测量撕裂半月板高度（TMH）以及第一和平均非侵入性破裂时间（NIBUT）。TMH是使用内置卡尺工具测量的，而NIBUT是通过仪器的自动算法计算的。
结果：BlandAltman图分析显示，TMH的两种仪器之间具有良好的一致性（95％协议限制（LoA），-0.17至0.16），但不是第一个NIBUT(95%LoA，-8.13至14.79）和平均NIBUT（95%LoA，-7.89至10.32）。使用IDRA测量的首次和平均NIBUT的值明显短于K5M（差异=中位数（IQR）-2.75（-6.48--0.28）s，p<0.001，差异=中位数（IQR）-1.65（-3.97-1.89）s，p分别=0.008)。用K5M测量的TMH(p=0.037)和NIBUT平均值(p=0.033)，以及IDRA测得的TMH(p=0.040)，在三个测量时间内表现出不稳定的测量结果。其余参数在三次重复测量时表现出稳定性。
结论：NIBUT测量值在IDRA和K5M之间不可互换，而TMH在两种仪器之间差异不大。使用不同的眼表分析仪时，请务必谨慎，以最大程度地减少比较多个测量结果时的误差。
OBJECTIVE: To evaluate the repeatability and agreement in dry eye measurements using Oculus Keratograph 5M (K5M) and SBM Sistemi
IDRA (
IDRA).
METHODS: A total of 108 participants were enrolled and 108 eyes were evaluated. Tear meniscus height (TMH) and first and average non-invasive break-up time (NIBUT) were measured using the K5M and
IDRA (order randomly assigned). TMH was measured using the built-in caliper tool while NIBUT was computed by the automatic algorithm of the instruments.
RESULTS: The Bland Altman plots analysis showed a good agreement between the two instruments for TMH (95 % Limits of Agreement (LoA), -0.17 to 0.16), but not the first NIBUT (95 % LoA, -8.13 to 14.79) and average NIBUT (95 % LoA, -7.89 to 10.32). The values of the first and average NIBUT measured using
IDRA were significantly shorter than in K5M (difference = median (IQR) -2.75 (-6.48- -0.28)s, p < 0.001 and difference = median (IQR) -1.65 (-3.97-1.89)s, p = 0.008 respectively). The TMH (p = 0.037) and NIBUT average (p = 0.033) measured by K5M, as well as the TMH (p = 0.040) measured by IDRA, exhibited unstable measurements across the three measurement times. The remaining parameters exhibited stability with three repeated measurements.
CONCLUSIONS: The NIBUT measurements are not interchangeable between
IDRA and K5M, while the TMH was little difference between the two instruments. It is important to exercise caution when using different ocular surface analyzers to minimize errors in comparing multiple measurements.
