活石马铃薯(PlectranthusesculenthusN.E.Br)对血清葡萄糖的影响,糖化血红蛋白(HbA1C),血清甘油三酯,总胆固醇,高密度脂蛋白(HDL),低密度脂蛋白(LDL),极低密度脂蛋白(VLDL),肝苹果酸酶(ME),使用标准技术研究了链脲佐菌素诱导的糖尿病大鼠的异柠檬酸脱氢酶(IDH)和过氧化氢酶活性。以LDL与HDL和总胆固醇与HDL的比值计算大鼠的动脉粥样硬化指数(AI)和冠状动脉危险指数(CRI),分别。非糖尿病患者的血清葡萄糖,糖尿病对照和糖尿病大鼠给予livingstone马铃薯掺入饲料(测试饲料)分别为92.58±3.97、352.30±4.88和165.50±7.88mg/dl,分别。第3组糖尿病大鼠摄入试验饲料,使其血糖显著下降(P<0.05),HbA1c,甘油三酯,胆固醇,LDL,VLDL,AI和CRI,但显著增加(P<0.05)肝脏的ME水平,IDH,过氧化氢酶和血清HDL与糖尿病对照大鼠相比,这些参数与非糖尿病大鼠相比有显着变化(P<0.05)。非糖尿病患者的饲料摄入量,在实验的最后一周,接受测试饲料的糖尿病对照和糖尿病大鼠分别为133.34±1.32、137.84±5.77和146.38±4.33g/大鼠/周。尽管采食量增加,但与非糖尿病大鼠相比,糖尿病对照大鼠记录到显著的体重减轻(P<0.05)。标准饲料和试验饲料的化学分析表明,标准大鼠饲料含有15.00±0.78%的蛋白质,7.24±1.20%脂肪,31.55±2.62%碳水化合物,能量值为290.65±4.77千卡/100克,10%粗纤维和0.12±0.04mg没食子酸当量,而试验饲料含有40.10±0.16%碳水化合物,17.22±0.40%蛋白质,22.16±0.34%脂肪,能量值为428.70±2.12千卡/100克,8.51±0.16%粗纤维,1.3±0.2mg没食子酸当量/g样品和与标准槲皮素相当的强抗氧化活性。该研究显示了livingstone马铃薯在糖尿病和高脂血症管理中的潜力。
The effect of livingstone potato (Plectranthus esculenthus N.E.Br) on serum glucose, glycated hemoglobin (HbA1C), serum triglyceride, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), hepatic malic enzyme (ME), isocitrate dehydrogenase (IDH) and catalase activities of Streptozotocin induced diabetic rats were investigated using standard techniques. The atherogenic index (AI) and coronary risk index (CRI) of the rats were calculated as the ratios of LDL to HDL and total cholesterol to HDL, respectively. The serum glucose of the non-diabetic, diabetic control and diabetic rats given livingstone potato incorporated feeds (test feed) were 92.58 ± 3.97, 352.30 ± 4.88 and 165.50 ± 7.88 mg/dl, respectively. Intake of the test feed by the diabetic rats of group 3, resulted in significant (P < 0.05) decrease of their serum glucose, HbA1c, triglyceride, cholesterol, LDL, VLDL, AI and CRI but significant increase (P < 0.05) of hepatic levels of ME, IDH, catalase and serum HDL compared with the diabetic control rats that had significant alteration of these parameters (P < 0.05) compared with the non-diabetic rats. The feed intakes of the non-diabetic, diabetic control and diabetic rats given the test feed were 133.34 ± 1.32, 137.84 ± 5.77 and 146.38 ± 4.33 g/rat/week by the last week of experimentation. The diabetic control rats recorded significant loss of weight (P < 0.05) compared with the non diabetic rats despite increased feed intake. Chemical analysis of the standard and test feeds showed that the standard rat feed contained 15.00 ± 0.78% protein, 7.24 ± 1.20% fat, 31.55 ± 2.62% carbohydrates, energy value of 290.65 ± 4.77 kcal/100 g, 10% crude fiber and 0.12 ± 0.04 mg Gallic Acid Equivalent while the test feed contained 40.10 ± 0.16% carbohydrates, 17.22 ± 0.40% protein, 22.16 ± 0.34% fat, energy value of 428.70 ± 2.12 kcal/100 g, 8.51 ± 0.16% crude fiber, 1.3 ± 0.2 mg Gallic Acid Equivalent/g of sample and strong antioxidant activity comparable to standard quercetin. The study shows the potentials of livingstone potato in the management of diabetes and hyperlipidemia.