背景:在这项研究中,我们研究了中国年轻人中高尿酸血症(HU)与高血压(HTN)之间的关联.此外,在HTN患者中发现左心室壁增厚与HU之间的相关性.
方法:总之,研究纳入了360例HTN患者和1991例血压正常(NBP)的年轻人。收集参与者特征。单变量和多变量逻辑回归检验用于确定HU和HTN的存在之间的相关性。以及HTN患者室间隔增厚与HU的相关性。
结果:中国青年HTN患者的HU患病率明显高于青年NBP(36.39%vs.16.93%)。单变量分析显示,有8个因素与HTN的存在相关,p值<0.001,包括HU,男性,体重指数(BMI)≥24kg/m2,总胆固醇(TC)>5.17mmol/L,甘油三酯(TG)>1.70mmol/L,高密度脂蛋白胆固醇(HDL-C)<1.0mmol/L,空腹血糖(FBG)>6.10mmol/L和脂肪肝。调整这些协变量后,多变量分析显示,HU[优势比(OR):1.47,95%置信区间(CI):1.10-1.95,p=0.008]在年轻人中与HTN保持独立关联。此外,单变量和多变量逻辑分析显示,HU对年轻HTN患者室间隔增厚(校正OR=1.81,95%CI:1.05-3.11,P=0.03)和左心室后壁增厚(校正OR=2.28,95%CI:1.28-4.08,P=0.005)的存在保持独立作用。
结论:HU与青年HTN独立相关。HU与左心室壁增厚独立相关,包括室间隔和左心室后壁,在患有HTN的年轻人中。
BACKGROUND: In this study, we examine the association between the hyperuricemia(HU) and hypertension(HTN) in Chinese young adults. Besides, the correlation between the occurrence of thickened left ventricular wall and HU was identified in patients with HTN.
METHODS: In all, 360 patients with HTN and 1991 young adults with normal blood pressure(NBP) were enrolled in the study. Participant characteristics were collected. Univariable and multivariable logistic regression tests were utilized to identify the correlation between the presence of HU and HTN, and the correlation between the occurrence of thickened ventricular septum and HU in patients with HTN.
RESULTS: The prevalence of HU in Chinese young adults with HTN was significantly higher than young adults with NBP(36.39% vs. 16.93%). Univariable analyses revealed that 8 factors were related with the presence of HTN with p value < 0.001, including HU, male, body mass index(BMI) ≥ 24 kg/m2, total cholesterol(TC) > 5.17mmol/L, triglyceride(TG) > 1.70mmol/L, high density lipoprotein cholesterol(HDL-C) < 1.0mmol/L, fasting blood glucose(FBG) > 6.10mmol/L and fatty liver. After adjusting these covariates, multivariable analysis revealed that HU[odds ratio(OR):1.47, 95% confidence interval(CI): 1.10-1.95, p = 0.008] remained independent association with HTN in young adults. Additionally, univariable and multivariable logistic analyses revealed that HU kept the independent effect on the presence of thickened interventricular septum(adjusted OR = 1.81, 95% CI: 1.05-3.11, P = 0.03) and thickened left ventricular posterior wall(adjusted OR = 2.28, 95% CI: 1.28-4.08, P = 0.005) in young adults with HTN.
CONCLUSIONS: HU was independently associated with HTN in young adults. HU was independently correlated with thickened left ventricular wall, including interventricular septum and left ventricular posterior wall, in young adults with HTN.