■本研究旨在使用基于电导的模型分析健康灵长类动物和帕金森病中超直接途径中丘脑下核和苍白球偶联的尖峰模式。还研究了钙膜电位的影响。
■使用MATLAB7.14中的ODE45对基于电导的模型产生的耦合微分方程系统进行了仿真,以分析尖峰模式。
■对尖峰模式的分析表明,丘脑底核在超直接途径中具有来自苍白球的突触输入,能够显示两种类型的尖峰模式-不规则和有节奏。在健康和帕金森情况下,尖峰模式的表征已经根据它们的频率完成,趋势,和尖峰率。结果表明,节律模式不能解释帕金森病。Further,钙膜电位是确定该病病因的重要指标。
■这项工作表明,超直接途径中的丘脑底核和苍白球偶联可以解释帕金森病的症状。然而,谷氨酸和GABA受体引起的激发和抑制的整个过程受到模型去极化时间的限制。通过增加钙膜电位,健康模式和帕金森模式之间的相关性有所改善,然而,在有限的时间内。
UNASSIGNED: This study aimed to analyze the spiking patterns of subthalamic nucleus and globus pallidus coupling in hyperdirect pathway in healthy primates and in Parkinson\'s disease using a conductance-based model. The effect of calcium membrane potential has also been investigated.
UNASSIGNED: System of coupled differential equation arising from the conductance-based model has been simulated using ODE45 in MATLAB 7.14 to analyze the spiking patterns.
UNASSIGNED: Analysis of spiking patterns suggests that subthalamic nucleus with synaptic input from globus pallidus in hyperdirect pathways is capable of showing two types of spiking pattern - irregular and rhythmic. Characterization of spiking patterns in healthy and Parkinson condition has been done based on their frequency, trend, and spiking rate. Results indicate that rhythmic patterns does not account for Parkinson\'s disease. Further, calcium membrane potential is an important parameter to target for identifying the cause of this disease.
UNASSIGNED: This work demonstrates that subthalamic nucleus and globus pallidus coupling in hyperdirect pathway can account for Parkinson\'s symptoms. However, the entire process of excitations and inhibition caused by glutamate and GABA receptors is limited by the timing of depolarization of the model. There is improvement in the correlation between healthy and Parkinson\'s patterns by increase in calcium membrane potential, however, for a limited time.