背景:抑郁症和糖尿病是主要的健康挑战,沉重的经济社会负担,糖尿病患者并发抑郁症可能导致广泛的不良健康结果。尽管许多描述性研究强调了共病抑郁症的患病率及其相关因素,湖南的形势,中国,尚不清楚。因此,本研究旨在了解湖南省住院2型糖尿病(T2DM)患者并发抑郁的患病率及相关因素,中国。
方法:本横断面研究纳入中南大学附属湘雅医院内分泌科496例T2DM患者,湖南。参与者关于社会人口状况的数据,生活方式因素,T2DM相关特性,收集社会支持。使用医院焦虑和抑郁量表-抑郁分量表评估抑郁症。所有统计分析均使用R软件版本4.2.1进行。
结果:湖南地区住院T2DM患者中抑郁共病患病率为27.22%(95%置信区间[CI]:23.3-31.1%)。患有抑郁症的人与没有抑郁症的人在年龄上有显著差异,教育水平,人均家庭月收入,当前工作状态,目前的吸烟状况,饮酒现状,有规律的身体活动,糖尿病的持续时间,高血压,慢性肾病,中风,脂肪肝,糖尿病肾病,糖尿病视网膜病变,胰岛素的使用,HbA1c,和社会支持。多变量logistic回归模型显示胰岛素使用者(校正OR=1.86,95%CI:1.02-3.42)患抑郁症的风险较高,而那些有规律的身体活动(调整后的OR=0.48,95%CI:0.30-0.77)或更高的社会支持(调整后的OR=0.20,95%CI:0.11-0.34)的人患抑郁症的风险较低。基于该模型的受试者操作员特征曲线下面积为0.741,灵敏度为0.785,特异性为0.615。
结论:湖南地区住院2型糖尿病患者中抑郁的发生率为中度,中国。胰岛素治疗策略,有规律的身体活动,和社会支持与抑郁症显著独立相关,基于这三个因素的多变量模型表现出良好的预测性,可应用于临床实践。
Depression and diabetes are major health challenges, with heavy economic social burden, and comorbid depression in diabetes could lead to a wide range of poor health outcomes. Although many descriptive studies have highlighted the prevalence of comorbid depression and its associated factors, the situation in
Hunan, China, remains unclear. Therefore, this study aimed to identify the prevalence of comorbid depression and associated factors among hospitalized type 2 diabetes mellitus (T2DM) patients in
Hunan, China.
This cross-sectional study involved 496 patients with T2DM who were referred to the endocrinology inpatient department of Xiangya Hospital affiliated to Central South University,
Hunan. Participants\' data on socio-demographic status, lifestyle factors, T2DM-related characteristics, and social support were collected. Depression was evaluated using the Hospital Anxiety and Depression Scale-depression subscale. All statistical analyses were conducted using the R software version 4.2.1.
The prevalence of comorbid depression among hospitalized T2DM patients in
Hunan was 27.22% (95% Confidence Interval [CI]: 23.3-31.1%). Individuals with depression differed significantly from those without depression in age, educational level, per capita monthly household income, current work status, current smoking status, current drinking status, regular physical activity, duration of diabetes, hypertension, chronic kidney disease, stroke, fatty liver, diabetic nephropathy, diabetic retinopathy, insulin use, HbA1c, and social support. A multivariable logistic regression model showed that insulin users (adjusted OR = 1.86, 95% CI: 1.02-3.42) had a higher risk of depression, while those with regular physical activity (adjusted OR = 0.48, 95% CI: 0.30-0.77) or greater social support (adjusted OR = 0.20, 95% CI: 0.11-0.34) had a lower risk of depression. The area under the curve of the receiver operator characteristic based on this model was 0.741 with a sensitivity of 0.785 and specificity of 0.615.
Depression was moderately prevalent among hospitalized T2DM patients in
Hunan, China. Insulin treatment strategies, regular physical activity, and social support were significantly independently associated with depression, and the multivariable model based on these three factors demonstrated good predictivity, which could be applied in clinical practice.