背景:1996年,美国国家癌症研究所(NCI)提出了五个类别的乳腺细胞学诊断,以便为诊断报告带来一定程度的一致性。其中,第3类和第4类被稀疏研究。
目的:本研究旨在评估乳腺肿块中C3和C4的细针穿刺细胞学(FNAC)类别及其组织病理学相关性。
方法:在回顾性研究中,根据NCI对728个FNAC进行了分类;其中,将28例C3类和65例C4类与组织病理学诊断进行比较。
结果:在C3类的组织病理学检查中,18例(64.3%)例显示良性病变,10例(35.7%)例显示恶性肿瘤,在C4类别中,良性病变9例(13.8%),恶性肿瘤56例(86.2%)。细胞学分类为C3(64.3%)和C4(86.2%)的良恶性诊断例数之间存在显着统计学差异(P<0.001)。敏感性,特异性,正预测值,C4类别在恶性肿瘤诊断中的阴性预测值为84.8%,66.7%,86.2%,和64.3%,分别。
结论:FNAC的乳房是一个简单的,成本效益高,准确,快,相对不那么痛苦的过程,它继续在乳腺病变的管理中发挥着不可或缺的作用。我们的研究得出结论,C3和C4类别的良性和恶性诊断数量之间存在统计学上的显着差异。
BACKGROUND: In 1996, National Cancer Institute (NCI) proposed five categories for the diagnosis of breast cytology in order to bring a degree of uniformity to the diagnostic reporting. Of these, categories 3 and 4 were sparsely studied.
OBJECTIVE: The present study was undertaken for the evaluation of the fine needle aspiration cytology (FNAC) categories of C3 and C4 in the breast lump and its histopathological correlation.
METHODS: In the retrospective study, a total number of 728 FNACs were categorized according to the NCI; of these, 28 cases of category C3 and 65 cases of category C4 were compared with histopathological diagnoses.
RESULTS: On histopathological examination of category C3, 18 (64.3%) cases showed benign lesions and 10 (35.7%) cases showed malignancy and among the C4 category, benign lesions found in nine (13.8%) and malignancy found in 56 (86.2%) cases. There was a significant statistical difference between the number of benign and malignant diagnoses for cytological categories of C3 (64.3%) and C4 (86.2%) (P < 0.001). The sensitivity, specificity, positive predictive value, and negative predictive value of C4 category in the diagnoses of malignancy were 84.8%, 66.7%, 86.2%, and 64.3%, respectively.
CONCLUSIONS: FNAC of the breasts is a simple, cost-effective, accurate, quick, and relatively less painful procedure, and it continues to play an integral part in the management of breast lesions. Our study concluded that there was a statistically significant difference between the number of benign and malignant diagnoses for categories of C3 and C4.