背景:低密度脂蛋白胆固醇(LDL)在控制心血管疾病风险方面至关重要。自1972年以来,Friedewald公式已用于估计LDL浓度,虽然有一些限制。2013年,Martin等人。提出了一个类似但更准确的计算LDL的公式。
目的:为了评估新配方的适用性,我们称之为马丁-霍普金斯公式,在葡萄牙人口中,并将其与使用直接LDL的Friedewald公式进行比较。
方法:横断面研究,包括来自e_COR研究的1689名参与者。我们应用Martin-Hopkins和Friedewald公式估算LDL(LDL-M和LDL-F)。由于甘油三酯≥400mg/dL,12例未应用Friedewald公式。测量直接LDL,接受的显著性水平为p<0.05。
结果:在所有科目中,50.2%为男性,中位年龄为51(34)岁。LDL-D为117.0(44.0)mg/dL,LDL-M为114.6(43.7)mg/dL,LDL-F为113.8(43.2)mg/dL。LDL-M/LDL-D之间的Spearman系数(ρ)为0.987,LDL-F/LDL-D之间的Spearman系数为0.983,p=0.001。在糖尿病组(LDL-M/LDL-Dρ=0.987;LDL-F/LDL-Dρ=0.978,p=0.001)和高甘油三酯血症(LDL-M/LDL-Dρ=0.983;LDL-F/LDL-Dρ=0.982,p=0.001)中保持了这种强相关性。在协议方面,当LDL-D<100mg/dL时,LDL-M的κ=0.90。
结论:马丁-霍普金斯公式表现良好,适用性好,显示出相对于Friedewald公式的优越性,特别是LDL-D值<100mg/dL,糖尿病,和高甘油三酯血症。
BACKGROUND: Low-density lipoprotein cholesterol (LDL) is essential in managing cardiovascular disease risk. Since 1972, the Friedewald formula has been used to estimate LDL concentration, although with some limitations. In 2013, Martin et al. proposed a similar but more accurate formula for calculating LDL.
OBJECTIVE: To assess the applicability of the new formula, which we have named the Martin-Hopkins formula, in the Portuguese population and compare it with the Friedewald formula using direct LDL.
METHODS: Cross-sectional study, including 1689 participants from the e_COR study. We applied the Martin-Hopkins and Friedewald formulas for estimated LDL (LDL-M and LDL-F). The Friedewald formula was not applied in 12 cases due to triglycerides ≥400mg/dL. Direct LDL was measured and the accepted significance level was p<0.05.
RESULTS: Of the total subjects, 50.2% were male and had a median age of 51 (34) years. LDL-D was 117.0 (44.0) mg/dL, LDL-M was 114.6 (43.7) mg/dL and LDL-F was 113.8 (43.2) mg/dL. The Spearman coefficient (ρ) between LDL-M/LDL-D was 0.987 and between LDL-F/LDL-D was 0.983, p=0.001. This strong correlation was maintained in the group with diabetes (LDL-M/LDL-D ρ=0.987; LDL-F/LDL-D ρ=0.978, p=0.001) and hypertriglyceridemia (LDL-M/LDL-D ρ=0.983; LDL-F/LDL-D ρ=0.982, p=0.001). In terms of agreement, the highest value of κ=0.90 was obtained for LDL-M when LDL-D <100 mg/dL.
CONCLUSIONS: The Martin-Hopkins formula performed well and had good applicability, showing superiority in relation to the Friedewald formula, especially for LDL-D values <100 mg/dL, diabetes, and hypertriglyceridemia.