背景:在COVID-19大流行期间,参与基本服务或居住在高风险地区的人员感染的风险增加。我们使用血清阳性率研究评估了奥里萨邦几个高危人群中感染人员的比例。
方法:在7月至11月期间,2020年,来自6个城市多个高危人群的个人(Bhubaneswar,Berhampur,Cuttack,Malkangiri,Paralakhemundi,和Rourkela)在奥里萨邦,印度,在获得书面知情同意书后被招募到研究中。在罗氏Cobase441(罗氏诊断,Rotkreuz,瑞士)。关于社会人口统计学变量的信息,与确诊或疑似病例有关,和其他细节是使用电子数据采集工具收集的,并使用统计软件进行分析。
结果:在5434名个体中,COVID-19血清总阳性率为34.9%(95CI33.6-36.2)。血清阳性率从Rourkela的21.8%(95%CI,19.6-24.1)到Bhubaneswar的54.9%(95%CI,51.5-58.2)不等。囚犯血清阳性率最高(47.7%),其次是市政/环卫人员(43.5%),和其他办公室工作人员(40.8%)。多因素logistic回归显示18-29岁的参与者,30-44岁,贫民窟和自动售货区的居民,市政当局工作人员,囚犯,城市的居民Malkangiri,Cuttack,Paralakhemundi,布巴内斯瓦尔和以前有COVID-19病史的人是血清阳性的独立相关因素。
结论:奥里萨邦高危人群的COVID-19风险各不相同。未来的定期血清阳性率研究对于保护大流行期间参与前线活动的高风险人员至关重要。
Personnel involved in essential services or residing in high-risk areas during the COVID-19 pandemic are at increased risk of getting infected. We evaluated the proportion of personnel infected in several high-risk groups in Odisha using seroprevalence studies.
During July to November, 2020, individuals from multiple high-risk groups in 6 urban cities (Bhubaneswar, Berhampur, Cuttack, Malkangiri, Paralakhemundi, and Rourkela) in Odisha, India, were recruited to the study after obtaining written informed consent. Blood samples collected from the study participants were tested for IgG antibodies against COVID-19 in Roche Cobas e441 (Roche Diagnostics, Rotkreuz, Switzerland). Information on socio-demographic variables, association with a confirmed or suspected case, and other details were collected using an electronic data capture tool and analysed with a statistical software.
The overall COVID-19 seroprevalence was 34.9% (95%CI 33.6-36.2) among the 5434 individuals. The seroprevalence varied from 21.8% (95% CI, 19.6-24.1) in Rourkela to 54.9% (95% CI, 51.5-58.2) in Bhubaneswar. Seropositivity was maximum among prisoners (47.7%), followed by municipality/ sanitation staff (43.5%), and other office going staff (40.8%). Multivariate logistic regression indicated that participants aged 18-29 years, 30-44 years, residents of slums and vending zone, municipality staff, prisoners, residents of urban cities Malkangiri, Cuttack, Paralakhemundi, Bhubaneswar and those with previous history of COVID-19 were independent co-relates of seropositivity.
The risk of COVID-19 varied among the high-risk groups of Odisha. Periodic seroprevalence studies in future are essential to protect the high-risk personnel involved in frontline activities during the pandemic.