■单纯疱疹病毒(HSV),许多眼部病变的原因,可能会影响角膜上皮,基质,或内皮,上皮是最常受影响的位置。我们的目的是确定在Farwaniya医院1年内HSV角膜炎的频率和视觉结果,科威特。
■这个前瞻性观察性病例系列包括2022年9月至2023年9月期间就诊于门诊或眼外伤科的被诊断为HSV角膜炎的患者。完整的历史,人口统计概况,详细的眼睛和裂隙灯检查,在治疗前和治疗后记录视力评估.使用棉缕试验在四个角膜象限中评估基线角膜感觉。
■在227例感染性角膜炎患者中,72例(31.7%)被诊断为HSV角膜炎。平均(SD)年龄为45.86(16.06)岁,48例(66.7%)患者为男性。HSV角膜炎的亚型有27例(37.5%),树突状溃疡22例(30.6%),间质角膜炎有溃疡9例(12.5%),无溃疡8例(11.1%),地理溃疡6例(8.3%)。HSV角膜炎亚型之间的平均基线最佳校正远距视力(BCDVA)差异显着(P<0.001)。大多数患者(n=70,97.2%)有单侧眼睛受累,在1-2周内治疗,并证明BCDVA有所改善。尽管在所有HSV角膜炎亚型中BCDVA的改善,治疗后BCDVA中位数仍有显著差异(P<0.001).配对比较显示,树突状上皮性溃疡的眼睛治疗后BCDVA明显优于HSV间质角膜炎伴溃疡(P=0.003)或地理上皮性溃疡(P=0.005)的眼睛。治疗后,在54例(75.0%)和24例(33.3%)患者中检测到角膜雾霾和新生血管,分别。
■我们在科威特的一个省发现了大量的HSV角膜炎,以内皮炎为最常见的表现。在我们的系列中,基于有效指南的及时标准治疗干预措施导致所有HSV角膜炎亚型的BCDVA改善。表明早期治疗的重要性。然而,树突状上皮性溃疡眼的BCDVA显著优于地区性上皮性溃疡或HSV间质角膜炎伴溃疡的眼,表明初始HSV角膜炎亚型对视觉结局的影响。据我们所知,这是第一项在科威特医院中强调HSV角膜炎频率的研究,需要在该地区进行更大规模的研究,以进一步了解和管理病情。
UNASSIGNED: Herpes simplex virus (HSV), a cause of many ocular pathologies, may affect the corneal epithelium, stroma, or endothelium, with the epithelium as the most frequently affected location. We aimed to determine the frequency and visual outcomes of HSV keratitis over a 1-year period at Farwaniya Hospital, Kuwait.
UNASSIGNED: This prospective observational case series included patients diagnosed with HSV keratitis who presented to the outpatient or eye casualty department between September 2022 and September 2023. Full history, demographic profile, detailed ocular and slit-lamp examinations, and visual acuity assessments were recorded prior to and after treatment. Baseline corneal sensation was assessed in the four corneal quadrants using the cotton wisp test.
UNASSIGNED: Of the 227 patients who presented with infectious keratitis, 72 (31.7%) were diagnosed with HSV keratitis. The mean (SD) age was 45.86 (16.06) years, and 48 (66.7%) patients were male. The subtypes of HSV keratitis were endotheliitis in 27 (37.5%) patients, dendritic ulcer in 22 (30.6%), stromal keratitis with ulceration in 9 (12.5%) and without ulceration in 8 (11.1%), and geographic ulcer in 6 (8.3%). The mean baseline best-corrected distance visual acuity (BCDVA) differed significantly between the HSV keratitis subtypes (P < 0.001). Most patients (n = 70, 97.2%) had unilateral eye involvement, were treated within 1 - 2 weeks, and demonstrated improved BCDVA. Despite the improvement in BCDVA in all HSV keratitis subtypes, a significant difference in the median BCDVA remained after treatment (P < 0.001). Pairwise comparisons revealed a significantly better BCDVA after treatment in eyes with dendritic epithelial ulcers than in eyes with HSV stromal keratitis with ulceration (P = 0.003) or geographic epithelial ulcers (P = 0.005). After treatment, corneal haze and neovascularization were detected in 54 (75.0%) and 24 (33.3%) patients, respectively.
UNASSIGNED: We detected a substantial frequency of HSV keratitis in one of the governorates of Kuwait, with endotheliitis as the most common manifestation. Timely standard treatment interventions based on valid guidelines resulted in BCDVA improvement in all subtypes of HSV keratitis in our series, indicating the importance of early treatment. However, the BCDVA in eyes with dendritic epithelial ulcers remained substantially better than that in eyes with geographic epithelial ulcers or HSV stromal keratitis with ulceration, signifying the effect of the initial HSV keratitis subtype on visual outcomes. To our knowledge, this is the first study to highlight the frequency of HSV keratitis in a Kuwaiti hospital, and larger-scale research in this region is needed to further understand and manage the condition.