目的:比较无肾炎和肾损害的过敏性紫癜(HSP)患儿的尿酸水平,和不同的病理等级。
方法:本研究共纳入451名儿童,其中64例HSP无肾炎,387例HSP有肾损害。年龄,性别,尿酸,尿素,对肌酐和胱抑素C水平进行了综述.还回顾了肾损害患者的病理学发现。
结果:在患有肾损害的HSP儿童中,44是I级,167为II级,176为III级。年龄差异显著,尿酸,尿素,两组肌酐和胱抑素C水平比较(P<0.05,均)。相关性分析显示,无肾炎HSP患儿尿酸水平与尿素、肌酐水平呈正相关(p<0.05)。HSP肾损害患儿尿酸水平与年龄呈正相关,尿素,肌酐和胱抑素C水平(p<0.05,均)。回归分析发现,不添加任何校正因子,两组之间的尿酸水平存在显着差异;然而,在调整病理等级后,不再有显著差异。
结论:无肾炎和肾功能损害的HSP患儿尿酸水平存在显著差异。肾损害组的尿酸水平明显高于无肾炎HSP组。尿酸水平仅与肾损害的存在或不存在有关,没有达到病理等级。
To compare uric acid levels in children with Henoch-Schonlein purpura (HSP)without nephritis and with renal damage, and at different pathological grades.
A total of 451 children were enrolled in this study, including 64 with HSP without nephritis and 387 HSP with kidney damage. Age, gender, uric acid, urea, creatinine and cystatin C levels were reviewed. Pathological findings of those with renal impairment were also reviewed.
Among the HSP children with renal damage, 44 were grade I, 167 were grade II and 176 were grade III. There were significant differences in age, uric acid, urea, creatinine and cystatin C levels between the two groups (p<0.05, all). Correlation analysis showed that uric acid levels in children with HSP without nephritis were positively correlated with urea and creatinine levels (p<0.05). Uric acid levels in HSP children with renal damage was positively correlated with age, urea, creatinine and cystatin C levels (p<0.05, all). Regression analysis found that, without adding any correction factors, there were significant differences in uric acid levels between the two groups; however, after adjusting for pathological grade, there was no longer a significant difference.
There were significant differences of uric acid levels in children with HSP without nephritis and with renal impairment. Uric acid levels in the renal impairment group were significantly higher than that in the HSP without nephritis group. Uric acid levels were related to only the presence or absence of renal damage, not to the pathological grade.