目的:为了描述基线特征,临床表现,影像学检查和结果,并确定潜在的预后因素在队列诊断为脑静脉血栓形成(CVT)。
方法:回顾性,单中心,纳入2016年1月至2020年12月诊断为CVT的成年患者的观察性研究.通过电子病历审查变量。
结果:共纳入35例患者,诊断时的中位年龄为50.3(+/-17.8)岁,大多数是女性(74.4%)。几乎95%的患者表现出至少一种CVT发展的危险因素。急性期使用肝素的比例为97.1%;其中,75%为低分子量肝素。复合事件(死亡,重症监护室入院,美国国立卫生研究院出院时卒中量表>3,CVT复发,大出血,或存在并发症)在前两周内发生了28.6%(10例患者)。在平均3.3年的随访中,14.3%死亡(其中,只有一名患者的死亡是由CVT引起的),1例患者出现大出血,无患者出现CVT复发.
结论:在我们的队列中,CVT更频繁地影响具有至少一个CVT发展风险因素的年轻女性。CT上水肿的存在和皮质类固醇治疗与不良的短期预后相关。在死亡率方面观察到良好的长期预后,复发,和出血。
OBJECTIVE: To describe the baseline characteristics, clinical presentation, imaging tests and outcomes, and identify potential prognostic factors in a cohort of patients diagnosed with cerebral venous thrombosis (CVT).
METHODS: This retrospective, single-center, observational study included adult patients diagnosed with CVT from January 2016 to December 2020. The variables were reviewed using electronic medical records.
RESULTS: A total of 35 patients were included, with a median age at diagnosis of 50.3 (+/- 17.8) years, and the majority being women (74.4%). Nearly 95% of the patients presented at least one risk factor for the development of CVT. Heparins were used for the acute phase in 97.1% of cases, with 75% of those being low molecular weight heparins.During the first two weeks, a compound event (death, intensive care unit admission, National Institute of Health Stroke Scale at discharge >3, CVT recurrence, major bleeding, or the presence of complications) occurred in 28.6% of patients (10 patients).Over the mean follow-up period of 3.3 years, 14.3% of the patients died (with only one death attributed to CVT), one patient experienced major bleeding, and no patients had a recurrence of CVT.
CONCLUSIONS: In our cohort, CVT predominantly affected young women with at least one risk factor for its development. The presence of edema on CT and corticosteroid treatment were associated with a poor short-term prognosis. However, we observed a favorable long-term prognosis in terms of mortality, recurrence, and bleeding.