背景:异速体形指数(ABSI)和臀部指数(HI),以及多性状体型表型,尚未比较它们与炎症标志物的关联。这项研究的目的是使用来自欧洲癌症与营养前瞻性调查(EPIC)和英国生物库队列的数据,检查新型和传统人体测量指标与炎症之间的关系。
方法:来自EPIC(n=17,943,69.1%的女性)和UKBiobank(n=426,223,53.2%的女性)的参与者以及人体测量指数和C反应蛋白(CRP)的数据被纳入该横断面分析。EPIC中的一部分女性也有至少一项白细胞介素测量,肿瘤坏死因子α,干扰素γ,瘦素,和脂联素。通过对身高的主成分(PC)分析得出了四种不同的体型表型,体重,体重指数(BMI),腰围(WC)和臀围(HC),腰臀比(WHR)。PC1描述了总体肥胖,PC2高,低WHR,PC3高和中央肥胖,和PC4高BMI和体重,低WC和HC,提示一种运动表型。ABSI,HI,还计算了腰高比和腰臀指数(WHI).分别在EPIC和UKBiobank中进行线性回归模型,按性别分层并调整年龄,吸烟状况,教育,和身体活动。结果也合并在随机效应荟萃分析中。
结果:传统人体测量指数,特别是BMI,WC,体重与CRP水平呈正相关,在男人和女人。体形表型也显示出与CRP的明显关联。具体来说,PC2在EPIC和英国生物银行中显示出与CRP呈负相关,同样的高度。PC3与女性的CRP呈负相关,而在男性中观察到正相关。
结论:体型和体脂分布的具体指标显示出与成人炎症的不同关联。值得注意的是,我们的结果表明,在女性中,身高可以减轻较高的WC和HC对炎症的影响。这表明肥胖亚型在其炎症潜能方面表现出实质性的变化。这可能对炎症相关的慢性疾病有影响。
BACKGROUND: The allometric body shape index (ABSI) and hip index (HI), as well as multi-trait body shape phenotypes, have not yet been compared in their associations with inflammatory markers. The aim of this study was to examine the relationship between novel and traditional anthropometric indexes with inflammation using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts.
METHODS: Participants from EPIC (n = 17,943, 69.1% women) and UK Biobank (n = 426,223, 53.2% women) with data on anthropometric indexes and C-reactive protein (CRP) were included in this cross-sectional analysis. A subset of women in EPIC also had at least one measurement for interleukins, tumour necrosis factor alpha, interferon gamma, leptin, and adiponectin. Four distinct body shape phenotypes were derived by a principal component (PC) analysis on
height, weight, body mass index (BMI), waist (WC) and hip circumferences (HC), and waist-to-hip ratio (WHR). PC1 described overall adiposity, PC2 tall with low WHR, PC3 tall and centrally obese, and PC4 high BMI and weight with low WC and HC, suggesting an athletic phenotype. ABSI, HI, waist-to-
height ratio and waist-to-hip index (WHI) were also calculated. Linear regression models were carried out separately in EPIC and UK Biobank stratified by sex and adjusted for age, smoking status, education, and physical activity. Results were additionally combined in a random-effects meta-analysis.
RESULTS: Traditional anthropometric indexes, particularly BMI, WC, and weight were positively associated with CRP levels, in men and women. Body shape phenotypes also showed distinct associations with CRP. Specifically, PC2 showed inverse associations with CRP in EPIC and UK Biobank in both sexes, similarly to
height. PC3 was inversely associated with CRP among women, whereas positive associations were observed among men.
CONCLUSIONS: Specific indexes of body size and body fat distribution showed differential associations with inflammation in adults. Notably, our results suggest that in women,
height may mitigate the impact of a higher WC and HC on inflammation. This suggests that subtypes of adiposity exhibit substantial variation in their inflammatory potential, which may have implications for inflammation-related chronic diseases.