背景:心肌缺血再灌注损伤(MIRI)定义为短暂中断血液供应后恢复到心肌的血流,对缺血心肌造成更严重的损害。然而,目前,再灌注疗法是缺血性心肌病的首选疗法,这无疑会导致MIRI,因此,它已成为影响冠状动脉疾病预后的挑战性问题。
方法:在WebofScienceCoreCollection数据库中检索了2000年1月1日至2023年10月1日发表的与MIRI治疗相关的论文。使用VOSviewer和CiteSpace进行了文献计量分析,以阐明进展和热点。
结果:来自64个国家的3304篇论文,2134个研究机构和13228名作者参加了这项研究。其中,中国贡献的论文最多,影响最大,而美国拥有最广泛的伙伴关系。第四军医大学是主要研究机构。最有价值的作者包括Chattipakorn,尼蓬,Chattipakorn,Siripornc,杨,简和杨,杨。
结论:在过去的20年里,MIRI疗法的研究取得了重大进展。需要进一步的研究来探索各种治疗方案之间的相互作用。未来的调查将强调纳米载体,心脏再生,和干细胞疗法。我们的研究从文献计量的角度确定了MIRI的研究热点,预测未来趋势,并为MIRI治疗研究提供了新的见解。
BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) is defined as the restoration of blood flow to the myocardium after a brief interruption of blood supply, causing more severe damage to the ischemic myocardium. However, currently, reperfusion therapy is the preferred therapy for ischemic cardiomyopathy, which undoubtedly causes MIRI, and thus it has become a challenging issue affecting the prognosis of coronary artery disease.
METHODS: A search was conducted in the Web of Science Core Collection database for papers relevant to MIRI therapy published between 1 January 2000 and 1 October 2023. Bibliometric analyses were performed using VOSviewer and CiteSpace to elucidate the progress and hotspots.
RESULTS: 3304 papers from 64 countries, 2134 research institutions and 13,228 authors were enrolled in the study. Of these, China contributed the most papers and had the biggest impact, while the United States had the most extensive partnership. The Fourth Military Medical University was the primary research institution. The most valuable authors include Chattipakorn, Nipon, Chattipakorn, Siriporn c, Yang, Jian and Yang, Yang.
CONCLUSIONS: Over the past 20 years, research on MIRI therapies has made significant strides. Further studies are necessary to explore the interactions between various therapeutic options. Future investigations will emphasize nanocarriers, cardiac regeneration, and stem cell therapies. Our study identifies MIRI research hotspots from a bibliometric perspective, forecasts future trends, and offers fresh insights into MIRI therapy research.