背景:下呼吸道感染(LRTIs)对老年人的发病率和死亡率有直接的显著影响。然而,LRTI在感染期后的影响仍未得到充分研究。我们旨在评估LRTIs对住院的短期至长期影响,死亡率,以及老年人的医疗保健利用率。
方法:分析了瑞典国家Kungsholmen老龄化与护理研究(SNAC-K)的数据,2001年至2019年的死亡率数据和2001年至2016年的医疗保健利用数据。根据社会人口统计学,确定LRTI暴露的参与者并与LRTI未暴露的参与者进行匹配,生活方式因素,以及功能和临床特征。统计模型评估了LRTI后住院风险,住院天数,医疗保健访问,和死亡率。
结果:在研究期间有567名LRTIs暴露的参与者,与1.701名未暴露的个体相匹配。暴露于LRTI的个体在1年时表现出住院风险增加(HR2.14,CI1.74,2.63),3年(HR1.74,CI1.46,2.07),和5年(HR1.59,CI1.33,1.89)。他们还经历了LRTI后住院时间更长(IRR1.40,CI1.18,1.66),更多医疗保健访问(IRR1.47,CI1.26,1.71),专科护理就诊(IRR1.46,CI1.24,1.73),和住院(IRR1.57,CI1.34,1.83)相比,非暴露参与者超过16年的潜在随访。此外,LRTI暴露参与者的19年死亡风险较高(HR1.45,CI1.24,1.70).与女性相比,男性与这些风险的关联更强。
结论:LRTI对老年人构成短期和长期风险,包括死亡风险增加,住院治疗,以及急性感染后的医疗保健访问,尽管这些影响随着时间的推移而减弱。与女性相比,男性在这些结果中表现出更高的风险。鉴于LRTI的潜在可预防性,有必要采取进一步的公共卫生措施来减轻感染风险。
BACKGROUND: Lower respiratory tract infections (LRTIs) have an immediate significant impact on morbidity and mortality among older adults. However, the impact following the infectious period of LRTI remains understudied. We aimed to assess the short- to long-term impact of LRTIs on hospitalization, mortality, and healthcare utilization in older adults.
METHODS: Data from the Swedish National Study of Aging and Care in Kungsholmen (SNAC-K) was analyzed, with data from 2001 to 2019 for mortality and 2001-2016 for healthcare utilization. LRTI-exposed participants were identified and matched with LRTI-nonexposed based on sociodemographics, lifestyle factors, and functional and clinical characteristics. Statistical models evaluated post-LRTI hospitalization risk, days of inpatient hospital admissions, healthcare visits, and mortality.
RESULTS: 567 LRTIs-exposed participants during the study period and were matched with 1.701 unexposed individuals. LRTI-exposed individuals exhibited increased risk of hospitalization at 1-year (HR 2.14, CI 1.74, 2.63), 3-years (HR 1.74, CI 1.46, 2.07), and 5-years (HR 1.59, CI 1.33, 1.89). They also experienced longer post-LRTI hospital stays (IRR 1.40, CI 1.18, 1.66), more healthcare visits (IRR 1.47, CI 1.26, 1.71), specialist-care visits (IRR 1.46, CI 1.24, 1.73), and hospital admissions (IRR 1.57, CI 1.34, 1.83) compared to nonexposed participants over 16-years of potential follow-up. Additionally, the 19-year risk of mortality was higher among LRTI-exposed participants (HR 1.45, CI 1.24, 1.70). Men exhibited stronger associations with these risks compared to women.
CONCLUSIONS: LRTIs pose both short- and long-term risks for older adults, including increased risks of mortality, hospitalization, and healthcare visits that transpire beyond the acute infection period, although these effects diminish over time. Men exhibit higher risks across these outcomes compared to women. Given the potential preventability of LRTIs, further public health measures to mitigate infection risk are warranted.