Health informatics

健康信息学
  • 文章类型: Journal Article
    将健康信息集成到大学信息系统中对于增强学生的支持和福祉具有巨大的潜力。尽管越来越多的研究强调了大学生面临的问题,包括压力,抑郁症,残疾,在信息学领域,很少在机构层面纳入卫生技术。
    本研究旨在调查大学系统内健康信息集成的现状,并提供设计建议以解决现有的差距和机会。
    我们使用以用户为中心的方法与利益相关者进行访谈和焦点小组会议,以收集对系统的全面见解和要求。方法涉及数据收集,分析,和建议的工作流的开发。
    这项研究的发现揭示了当前在大学信息系统中处理健康和残疾数据的过程中存在的缺陷。在我们的结果中,我们讨论了将健康相关信息集成到学生信息系统中的一些要求,如隐私和保密,及时沟通,任务自动化,残疾资源。我们提出了一个工作流程,将流程分为两个不同的组成部分:健康和残疾系统以及生活质量和健康的衡量标准。拟议的工作流程强调了学术顾问在促进支持和加强利益相关者之间的协调方面的重要作用。
    为了简化工作流程,利益相关者之间的有效协调和重新设计大学信息系统至关重要。然而,实施新系统将需要大量资金和资源。我们强烈强调加强标准化和监管以支持健康和残疾信息系统要求的重要性。通过采用标准化的做法和条例,我们可以确保所需支持系统的顺利有效实施。
    UNASSIGNED: Integrating health information into university information systems holds significant potential for enhancing student support and well-being. Despite the growing body of research highlighting issues faced by university students, including stress, depression, and disability, little has been done in the informatics field to incorporate health technologies at the institutional level.
    UNASSIGNED: This study aims to investigate the current state of health information integration within university systems and provide design recommendations to address existing gaps and opportunities.
    UNASSIGNED: We used a user-centered approach to conduct interviews and focus group sessions with stakeholders to gather comprehensive insights and requirements for the system. The methodology involved data collection, analysis, and the development of a suggested workflow.
    UNASSIGNED: The findings of this study revealed the shortcomings in the current process of handling health and disability data within university information systems. In our results, we discuss some requirements identified for integrating health-related information into student information systems, such as privacy and confidentiality, timely communication, task automation, and disability resources. We propose a workflow that separates the process into 2 distinct components: a health and disability system and measures of quality of life and wellness. The proposed workflow highlights the vital role of academic advisors in facilitating support and enhancing coordination among stakeholders.
    UNASSIGNED: To streamline the workflow, it is vital to have effective coordination among stakeholders and redesign the university information system. However, implementing the new system will require significant capital and resources. We strongly emphasize the importance of increased standardization and regulation to support the information system requirements for health and disability. Through the adoption of standardized practices and regulations, we can ensure the smooth and effective implementation of the required support system.
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  • 文章类型: Journal Article
    近年来,电子健康记录(EHR)的使用在医疗机构中变得越来越普遍,包括急诊科(ED)。EHR提供了许多优势,例如改进的文档,简化通信,加强病人护理。此外,EHR包含有关患者护理和治疗结果的重要信息,这开启了令人兴奋的研究机会。这项研究的目的是提供一个数据库,其中包含有关大型医院急诊科收治的患者的信息。在这项研究中,我们正在引入一个开放的数据库,该数据库来自伊斯法罕一所普通大学医院的电子健康记录,伊朗。这些数据是从2017年3月至2022年3月期间进入急诊科的患者中收集的,得出的数据库包含143,582例ED住院。该数据库包括分诊信息,ED入院患者,和服务。为了确保患者的隐私,所有患者特异性信息已从记录中删除.
    In recent years, the use of electronic health records (EHRs) has become increasingly prevalent in healthcare settings, including emergency departments (EDs). EHRs offer numerous advantages, such as improved documentation, streamlined communication, and enhanced patient care. Additionally, EHRs contain vital information about patient care and treatment outcomes, which opens up exciting research opportunities. The objective of this study was to present a database comprising information regarding patients admitted to the emergency department of a large hospital. In this study, we are introducing an open-access database sourced from the electronic health records of a general university hospital in Isfahan, Iran. The data were collected from patients admitted to the emergency department between March 2017 and March 2022, resulting in a database containing 143,582 ED stays. The database includes triage information, ED admission patients, and services. To ensure patient privacy, all patient-specific information has been removed from the records.
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  • 文章类型: Journal Article
    根据以前的报道,在沙特阿拉伯,非常高比例的个体未被诊断为2型糖尿病(T2DM).尽管进行了几次筛查和宣传活动,这些努力缺乏充分的可及性,消耗了大量的人力和物力。因此,开发机器学习(ML)模型可以增强基于人群的筛查过程。该研究旨在将新开发的ML模型的结果与经过验证的美国糖尿病协会(ADA)风险评估进行比较,以预测T2DM高危人群。
    患者年龄,性别,和从国家健康信息中心的数据集获得的风险因素用于构建和训练ML模型。为了评估开发的ML模型,在三个初级卫生保健中心进行了一项外部验证研究.从非糖尿病个体中选择随机样本(N=3400)。
    结果显示在AROC值为0.803的受试者工作特征(ROC)曲线中表示的灵敏度/100-特异性的绘图数据,95%CI:0.779-0.826。
    当前的研究揭示了一种新的ML模型,用于人群水平分类,该模型可以成为识别T2DM高危人群或已经患有T2DM但尚未诊断的人群的适当工具。
    UNASSIGNED: According to previous reports, very high percentages of individuals in Saudi Arabia are undiagnosed for type 2 diabetes mellitus (T2DM). Despite conducting several screening and awareness campaigns, these efforts lacked full accessibility and consumed extensive human and material resources. Thus, developing machine learning (ML) models could enhance the population-based screening process. The study aims to compare a newly developed ML model\'s outcomes with the validated American Diabetes Association\'s (ADA) risk assessment regarding predicting people with high risk for T2DM.
    UNASSIGNED: Patients\' age, gender, and risk factors that were obtained from the National Health Information Center\'s dataset were used to build and train the ML model. To evaluate the developed ML model, an external validation study was conducted in three primary health care centers. A random sample (N = 3400) was selected from the non-diabetic individuals.
    UNASSIGNED: The results showed the plotted data of sensitivity/100-specificity represented in the Receiver Operating Characteristic (ROC) curve with an AROC value of 0.803, 95% CI: 0.779-0.826.
    UNASSIGNED: The current study reveals a new ML model proposed for population-level classification that can be an adequate tool for identifying those at high risk of T2DM or who already have T2DM but have not been diagnosed.
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  • 文章类型: Journal Article
    目的:数字技术在外科手术中的使用正在迅速增加,从术前计划到术后性能评估的各种新应用。了解这些技术的临床和经济价值对于制定适当的卫生政策和购买决策至关重要。我们探索数字技术在外科手术中的潜在价值,并就如何评估这一价值达成专家共识。
    方法:采用改进的德尔菲和共识会议方法。Delphi轮用于生成优先主题和共识声明以供讨论。
    方法:组建了一个由14名专家组成的国际小组,代表相关利益相关者群体:临床医生,健康经济学家,卫生技术评估专家,政策制定者和行业。
    方法:使用范围界定问卷生成待回答的研究问题。第二份问卷被用来评估这些研究问题的重要性。最后的调查表用于生成供三个共识会议讨论的声明。经过讨论,小组就他们的协议级别从1到9进行了投票;其中1=强烈不同意,9=强烈同意。共识被定义为>7的平均协议水平。
    结果:确定了四个优先主题:(1)如何在数字手术中使用数据,(2)数字化外科技术的现有证据基础,(3)数字技术如何帮助外科培训和教育,以及(4)评估这些技术的方法。产生和完善了七项协商一致声明,最终共识级别为7.1至8.6。
    结论:数字技术在外科手术中的潜在好处包括减少外科手术实践中不必要的变化,增加手术机会和减少健康不平等。从整体上考虑整个外科生态系统的价值的评估至关重要,尤其是许多数字技术可能在手术室中同时进行交互。
    OBJECTIVE: The use of digital technology in surgery is increasing rapidly, with a wide array of new applications from presurgical planning to postsurgical performance assessment. Understanding the clinical and economic value of these technologies is vital for making appropriate health policy and purchasing decisions. We explore the potential value of digital technologies in surgery and produce expert consensus on how to assess this value.
    METHODS: A modified Delphi and consensus conference approach was adopted. Delphi rounds were used to generate priority topics and consensus statements for discussion.
    METHODS: An international panel of 14 experts was assembled, representing relevant stakeholder groups: clinicians, health economists, health technology assessment experts, policy-makers and industry.
    METHODS: A scoping questionnaire was used to generate research questions to be answered. A second questionnaire was used to rate the importance of these research questions. A final questionnaire was used to generate statements for discussion during three consensus conferences. After discussion, the panel voted on their level of agreement from 1 to 9; where 1=strongly disagree and 9=strongly agree. Consensus was defined as a mean level of agreement of >7.
    RESULTS: Four priority topics were identified: (1) how data are used in digital surgery, (2) the existing evidence base for digital surgical technologies, (3) how digital technologies may assist surgical training and education and (4) methods for the assessment of these technologies. Seven consensus statements were generated and refined, with the final level of consensus ranging from 7.1 to 8.6.
    CONCLUSIONS: Potential benefits of digital technologies in surgery include reducing unwarranted variation in surgical practice, increasing access to surgery and reducing health inequalities. Assessments to consider the value of the entire surgical ecosystem holistically are critical, especially as many digital technologies are likely to interact simultaneously in the operating theatre.
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  • 文章类型: Journal Article
    调查通过数字应用程序自我报告的长期COVID(LC)症状。探索各种人口统计学因素与LC症状强度之间的关联。
    回顾性病例系列研究。我们分析了2020年11月30日至2022年3月23日之间1008名LC患者的自我报告症状。
    英格兰和威尔士。
    在31家COVID-19后诊所使用医疗保健应用程序并自我报告LC症状的LC患者。
    报告的LC症状最高,与人口统计学因素和症状强度相关。
    确定了109个症状类别,疼痛(26.5%),神经心理问题(18.4%),疲劳(14.3%)和呼吸困难(7.4%)最普遍。自登记以来,报告的症状强度每月增加3.3%。年龄组68-77和78-87经历了更高的症状强度(32.8%和86%高,分别)与18-27岁年龄组相比。女性报告的症状比男性多9.2%,非白人LC患者报告的症状比白人LC患者高23.5%。较高的教育水平(国家职业资格(NVQ)3至NVQ5)与较少的症状强度(27.7%,减少62.8%和44.7%,分别)与受教育程度最低的(NVQ1-2)相比。较贫穷地区的人的症状比最贫穷地区的人少。在多重剥夺指数(IMD)十分位数和症状数量之间没有发现显着关联。
    治疗计划必须优先解决普遍的LC症状;我们建议持续支持LC诊所。人口统计学因素显著影响症状严重程度,强调需要有针对性的干预措施。这些发现可以为医疗保健政策提供信息,以更好地管理LC。
    UNASSIGNED: To investigate long COVID (LC) symptoms self-reported via a digital application. Explore associations between various demographic factors and intensity of LC symptoms.
    UNASSIGNED: A retrospective case series study. We analysed self-reported symptoms from 1008 individuals with LC between November 30, 2020, and March 23, 2022.
    UNASSIGNED: England and Wales.
    UNASSIGNED: Individuals with LC using the healthcare application in 31 post-COVID-19 clinics and self-reporting LC symptoms.
    UNASSIGNED: Highest reported LC symptoms, associations with demographic factors and intensity of symptoms.
    UNASSIGNED: 109 symptom categories were identified, with pain (26.5%), neuropsychological issues (18.4%), fatigue (14.3%) and dyspnoea (7.4%) the most prevalent. The intensity of reported symptoms increased by 3.3% per month since registration. Age groups 68-77 and 78-87 experienced higher symptom intensity (32.8% and 86% higher, respectively) compared to the 18-27 age group. Women reported 9.2% more intense symptoms than men, and non-white individuals with LC reported 23.5% more intense symptoms than white individuals with LC. Higher education levels (national vocational qualification (NVQ) 3 to NVQ 5) were associated with less symptom intensity (27.7%, 62.8% and 44.7% less, respectively) compared to the least educated (NVQ 1-2). People in less deprived areas had less intense symptoms than those in the most deprived area. No significant association was found between index of multiple deprivation (IMD) decile and number of symptoms.
    UNASSIGNED: Treatment plans must prioritise addressing prevalent LC symptoms; we recommend sustained support for LC clinics. Demographic factors significantly influence symptom severity, underlining the need for targeted interventions. These findings can inform healthcare policies to better manage LC.
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  • 文章类型: Journal Article
    背景:人工智能和聊天机器人技术在医疗保健中的集成由于其改善患者护理和简化历史记录的潜力而引起了极大的关注。作为人工智能驱动的对话代理,聊天机器人提供了彻底改变历史的机会,需要全面检查它们对医疗实践的影响。
    目的:本系统综述旨在评估角色,有效性,可用性,以及患者在病史记录中接受聊天机器人。它还研究了融入临床实践的潜在挑战和未来机遇。
    方法:系统搜索包括PubMed,Embase,MEDLINE(通过Ovid),中部,Scopus,和开放科学,并涵盖到2024年7月的研究。审查的研究的纳入和排除标准是基于PICOS(参与者,干预措施,比较器,结果,和研究设计)框架。人口包括使用医疗保健聊天机器人进行病史记录的个人。干预措施的重点是旨在促进病史记录的聊天机器人。感兴趣的结果是可行性,接受,以及基于聊天机器人的病史采集的可用性。未报告这些结果的研究被排除。除会议论文外,所有研究设计均符合纳入条件。只考虑了英语学习。对研究持续时间没有具体限制。主要搜索词包括“chatbot*”,“”对话代理*,\"\"虚拟助手,\"\"人工智能聊天机器人,\"\"病史,“和”历史记录。“观察性研究的质量使用STROBE(加强流行病学观察性研究的报告)标准进行分类(例如,样本量,设计,数据收集,和后续行动)。RoB2(风险偏倚)工具评估了随机对照试验(RCTs)中偏倚的领域和水平。
    结果:该综述包括15项观察性研究和3项RCT,以及来自不同医学领域和人群的综合证据。聊天机器人通过有针对性的查询和数据检索系统地收集信息,提高患者参与度和满意度。结果表明,聊天机器人具有很大的历史记录潜力,并且可以通过24/7自动数据收集来提高医疗保健系统的效率和可访问性。偏见评估显示,在15项观察性研究中,5项(33%)研究质量高,5项(33%)研究质量中等,5项(33%)研究质量低。在RCT中,2具有较低的偏见风险,1有高风险。
    结论:本系统综述为使用聊天机器人获取病史的潜在益处和挑战提供了重要见解。纳入的研究表明,聊天机器人可以增加患者的参与度,简化数据收集,改善医疗保健决策。为了有效地融入临床实践,设计用户友好的界面至关重要,确保强大的数据安全,并保持有同情心的患者-医生互动。未来的研究应该集中在改进聊天机器人算法上,提高他们的情绪智力,并将其应用扩展到不同的医疗保健环境,以充分发挥其在现代医学中的潜力。
    背景:PROSPEROCRD42023410312;www.crd.约克。AC.英国/普洛佩罗。
    BACKGROUND: The integration of artificial intelligence and chatbot technology in health care has attracted significant attention due to its potential to improve patient care and streamline history-taking. As artificial intelligence-driven conversational agents, chatbots offer the opportunity to revolutionize history-taking, necessitating a comprehensive examination of their impact on medical practice.
    OBJECTIVE: This systematic review aims to assess the role, effectiveness, usability, and patient acceptance of chatbots in medical history-taking. It also examines potential challenges and future opportunities for integration into clinical practice.
    METHODS: A systematic search included PubMed, Embase, MEDLINE (via Ovid), CENTRAL, Scopus, and Open Science and covered studies through July 2024. The inclusion and exclusion criteria for the studies reviewed were based on the PICOS (participants, interventions, comparators, outcomes, and study design) framework. The population included individuals using health care chatbots for medical history-taking. Interventions focused on chatbots designed to facilitate medical history-taking. The outcomes of interest were the feasibility, acceptance, and usability of chatbot-based medical history-taking. Studies not reporting on these outcomes were excluded. All study designs except conference papers were eligible for inclusion. Only English-language studies were considered. There were no specific restrictions on study duration. Key search terms included \"chatbot*,\" \"conversational agent*,\" \"virtual assistant,\" \"artificial intelligence chatbot,\" \"medical history,\" and \"history-taking.\" The quality of observational studies was classified using the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) criteria (eg, sample size, design, data collection, and follow-up). The RoB 2 (Risk of Bias) tool assessed areas and the levels of bias in randomized controlled trials (RCTs).
    RESULTS: The review included 15 observational studies and 3 RCTs and synthesized evidence from different medical fields and populations. Chatbots systematically collect information through targeted queries and data retrieval, improving patient engagement and satisfaction. The results show that chatbots have great potential for history-taking and that the efficiency and accessibility of the health care system can be improved by 24/7 automated data collection. Bias assessments revealed that of the 15 observational studies, 5 (33%) studies were of high quality, 5 (33%) studies were of moderate quality, and 5 (33%) studies were of low quality. Of the RCTs, 2 had a low risk of bias, while 1 had a high risk.
    CONCLUSIONS: This systematic review provides critical insights into the potential benefits and challenges of using chatbots for medical history-taking. The included studies showed that chatbots can increase patient engagement, streamline data collection, and improve health care decision-making. For effective integration into clinical practice, it is crucial to design user-friendly interfaces, ensure robust data security, and maintain empathetic patient-physician interactions. Future research should focus on refining chatbot algorithms, improving their emotional intelligence, and extending their application to different health care settings to realize their full potential in modern medicine.
    BACKGROUND: PROSPERO CRD42023410312; www.crd.york.ac.uk/prospero.
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  • 文章类型: Journal Article
    背景:根据护士分诊记录预测住院有可能增加护理。然而,需要仔细考虑为此目标选择哪些模型。具体来说,卫生系统将有不同程度的可用计算基础设施和预算限制。
    目标:为此,我们比较了深度学习的性能,基于变压器(BERT)模型的双向编码器表示,Bio-Clinical-BERT,使用包含术语频率-逆文档频率(TF-IDF)的词袋(BOW)逻辑回归(LR)模型。这些选择代表不同级别的计算要求。
    方法:使用2017年至2022年在西奈山卫生系统急诊科就诊的1,391,988名患者的数据进行了回顾性分析。这些模型在4家医院的数据上进行了训练,并在第五家医院的数据上进行了外部验证。
    结果:与BOW-LR-TF-IDF模型(0.81、0.83和0.84)相比,Bio-Clinical-BERT模型在受试者工作特征曲线下实现了更高的面积(0.82、0.84和0.85),在10,000;100,000;和〜1,000,000名患者的训练集中,分别。值得注意的是,这两个模型在使用分诊笔记进行预测方面都被证明是有效的,尽管业绩差距不大。
    结论:我们的研究结果表明,更简单的机器学习模型,如BOW-LR-TF-IDF,可以在资源有限的环境中充分发挥作用。鉴于对患者护理和医院资源管理的潜在影响,有必要进一步探索替代模型和技术,以增强这一关键领域的预测性能。
    RR2-10.1101/2023.08.07.23293699。
    BACKGROUND: Predicting hospitalization from nurse triage notes has the potential to augment care. However, there needs to be careful considerations for which models to choose for this goal. Specifically, health systems will have varying degrees of computational infrastructure available and budget constraints.
    OBJECTIVE: To this end, we compared the performance of the deep learning, Bidirectional Encoder Representations from Transformers (BERT)-based model, Bio-Clinical-BERT, with a bag-of-words (BOW) logistic regression (LR) model incorporating term frequency-inverse document frequency (TF-IDF). These choices represent different levels of computational requirements.
    METHODS: A retrospective analysis was conducted using data from 1,391,988 patients who visited emergency departments in the Mount Sinai Health System spanning from 2017 to 2022. The models were trained on 4 hospitals\' data and externally validated on a fifth hospital\'s data.
    RESULTS: The Bio-Clinical-BERT model achieved higher areas under the receiver operating characteristic curve (0.82, 0.84, and 0.85) compared to the BOW-LR-TF-IDF model (0.81, 0.83, and 0.84) across training sets of 10,000; 100,000; and ~1,000,000 patients, respectively. Notably, both models proved effective at using triage notes for prediction, despite the modest performance gap.
    CONCLUSIONS: Our findings suggest that simpler machine learning models such as BOW-LR-TF-IDF could serve adequately in resource-limited settings. Given the potential implications for patient care and hospital resource management, further exploration of alternative models and techniques is warranted to enhance predictive performance in this critical domain.
    UNASSIGNED: RR2-10.1101/2023.08.07.23293699.
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  • 文章类型: Journal Article
    目标:在2021年,SolentNHSTrust宣传了一位完全远程咨询精神科医生,以满足不断增长的临床需求。对该试点计划进行了评估以确定其成功。工作申请进行了内容分析,招聘和支持人员接受了采访,并对三名现在受雇的虚拟精神科医生进行了深入的滚动访谈。
    结果:我们对这种新的和创新的工作方式有了客观的了解,总的来说,表明在国家卫生服务(NHS)完全远程工作是可行的。
    结论:这些发现用于为远程招聘流程创建分步指南,概述了在保险箱中进行的必要步骤,迅速和成功的方式。本指南可以帮助其他NHS组织做广告,招聘和管理完全远程的员工。
    OBJECTIVE: In 2021, Solent NHS Trust advertised for a fully remote consultant psychiatrist to meet increasing clinical demand. This pilot scheme was evaluated to determine its success. The job applications underwent content analysis, recruitment and support staff were interviewed, and in-depth rolling interviews were conducted with the three now-employed virtual psychiatrists.
    RESULTS: We have gained an objective understanding of this new and innovative way of working and, overall, shown that fully remote working in the National Health Service (NHS) is feasible.
    CONCLUSIONS: The findings were used to create a step-by-step guide for the remote hiring process, which outlines the necessary steps for conducting it in a safe, swift and successful way. This guide could help other NHS organisations to advertise, recruit and manage fully remote employees.
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  • 文章类型: Journal Article
    背景:历史上,疾病和非战斗伤害(DNBI)通常占军事任务期间所有医疗事件的70%-95%。有,然而,瑞典士兵在部署期间没有全面的医疗统计数据。
    方法:在联合国马里多层面综合稳定团期间,气候数据和医疗门诊健康监测数据是为部署到提姆布克托的瑞典士兵编制的,2015年至2019年。分析了气候数据与医疗门诊健康监测数据之间的相关性。
    结果:战斗伤害占医疗保健访问的0.4%,而疾病占53.6%,非战斗伤害为46%,大部分是肌肉骨骼损伤。高温的组合,湿度,湿度太阳辐射和良好的能见度,在夏季轮换周期间,造成的伤害和热应激事件比任何其他时期都多。
    结论:肌肉骨骼损伤是前往瑞典营地医院就诊的主要原因。高温期间损伤和热应激增加,湿度,湿度太阳辐射和良好的能见度。缺乏医疗数据,即未知数量的寻求医疗保健的独特患者,原因代码并不总是与主要诊断相关,重新审视与诊断无关的情况,对健康危险因素的复杂解释。
    BACKGROUND: Historically, diseases and non-battle injuries (DNBI) typically stand for 70%‒95% of all medical events during military missions. There is, however, no comprehensive compilation of medical statistics for Swedish soldiers during deployment.
    METHODS: During United Nations Multidimensional Integrated Stabilization Mission in Mali, climate data and medical outpatient health surveillance data were compiled for Swedish soldiers deployed to Timbuctoo, between 2015 and 2019. Correlations between climate data and medical outpatient health surveillance data were analysed.
    RESULTS: Battle injuries accounted for 0.4% of the visits to healthcare, while diseases accounted for 53.6%, and non-battle injuries for 46%, the majority being musculoskeletal injuries. The combination of high temperature, humidity, sun radiation and good visibility, during summer rotation weeks, caused more events of injuries and heat stress than any other period.
    CONCLUSIONS: Musculoskeletal injuries were the major cause for visits to the Swedish camp hospital. Injuries and heat stress increased during periods of high temperature, humidity, sun radiation and good visibility. Lack of medical data, i.e. unknown number of unique patients seeking healthcare, cause codes not always connected to a primary diagnosis, and revisits not being connected to a diagnose, complicated interpretation of health risk factors.
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  • 文章类型: Editorial
    蛋白质控制个体患者对药物的反应,是它们的受体,转运蛋白或酶。这些蛋白质受基因控制。这些基因和多个基因之间的相互作用的研究是药物基因组学,单个基因被称为药物基因。对药物遗传学的最大理解是药物代谢酶,细胞色素P450.几乎整个英国人口都可能具有至少一种控制这些P450的遗传变异,从而控制代谢能力的表型。这意味着两个接受相同药物和剂量的患者可能有非常不同的反应,从不良反应到无效。一个军人对药物的反应可以从他们的药物遗传学预测,作为一个例子;对常用的“止痛药”的反应,可待因,曲马多,氢可酮或羟考酮。这些阿片样物质通过细胞色素2D6代谢成其活性形式。四种表型对个体的代谢能力进行分类:超快,广泛的,中级或贫困。代谢不良的人有可能从列出的阿片类药物中缓解疼痛无效,而超快速代谢剂存在过度暴露和随后的依赖性或滥用的风险。在欧洲白人人口中,表型的流行是众所周知的,可以用来指导处方;然而,在尼泊尔或太平洋岛民等其他人群中,这些表型的分布未知。基因分型为英国武装部队提供了精确治疗患者和具有成本效益的药物使用框架,以及可能为少数群体提供公平。
    Proteins control individual patient\'s response to pharmaceutical medication, be they receptors, transporters or enzymes. These proteins are under the control of genes. The study of these genes and the interplay between multiple genes is pharmacogenomics, with individual genes being termed pharmacogenes. The greatest understanding of pharmacogenetics is of the drug metabolising enzymes, the cytochrome P450s. Almost the entire UK population is likely to have at least one genetic variant that controls these P450s and thus the phenotype for metabolic competence. This means two patients receiving the same medication and dose may have very different responses, from adverse reaction to being ineffective. An individual military person\'s response to medications can be predicted from their pharmacogenetics, as an example; the response to the commonly prescribed \'pain killers\', codeine, tramadol, hydrocodone or oxycodone. These opioids are metabolised into their active forms by the cytochrome 2D6. Four phenotypes classify an individual\'s metabolic competency: ultra-rapid, extensive, intermediate or poor. A poor metaboliser is at risk of ineffective pain relief from one of the opioids listed, whereas an ultra-rapid metaboliser is at risk of overexposure and subsequent dependency or abuse. In white European populations, the prevalence of the phenotypes is well known and may be used to guide prescribing; however, in other populations such as Nepalese or Pacific Islander the distribution of these phenotypes is unknown. Genotyping provides a framework for the precise treatment of patients and cost-effective use of medication for the UK Armed Forces, as well as potentially providing equity for minority groups.
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