目的:糜烂性手部骨关节炎(eHOA)是手部OA的一种亚型,在手指关节中发展,并通过临床特征(手部疼痛/残疾,炎症,和糜烂)提示炎症或代谢过程。
方法:这是一个纵向嵌套病例队列设计,在基线和48个月时有手部X光片的骨关节炎倡议参与者中,和基线时收集的生物标本。我们对Kellgren-Lawrence≥2个关节≥1个关节且在48个月时存在中央侵蚀但在基线时未出现的个体进行了入射射线照相eHOA分类。我们使用随机代表性样本(n=1,282)进行比较。我们测量了炎症的血清生物标志物,胰岛素抵抗和血糖异常,和脂肪因子使用免疫测定和酶比色程序,对案件状态视而不见。
结果:86名参与者开发了入射射线照相eHOA。在根据年龄调整的多变量分析中,性别,种族,吸烟,BMI,经过多次分析的调整,射入影像学eHOA与白细胞介素-7水平升高相关(每SD的RR=1.30[95%CI1.09,1.55]p趋势0.01).
结论:这项探索性研究表明,白细胞介素-7是一种炎性细胞因子,EHOA事件,而代谢炎症的其他细胞因子或生物标志物则不相关。白细胞介素7可能介导易感骨关节炎手指关节的炎症和组织损伤,并参与糜烂进程。
OBJECTIVE: Erosive hand osteoarthritis (eHOA) is a subtype of hand osteoarthritis (OA) that develops in finger joints with pre-existing OA and is differentiated by clinical characteristics (hand pain/disability, inflammation, and erosions) that suggest inflammatory or metabolic processes.
METHODS: This was a longitudinal nested case-cohort design among Osteoarthritis Initiative participants who had hand radiographs at baseline and 48-months, and biospecimens collected at baseline. We classified incident radiographic eHOA in individuals with ≥1 joint with Kellgren-Lawrence ≥2 and a central erosion present at 48-months but not at baseline. We used a random representative sample (n = 1282) for comparison. We measured serum biomarkers of inflammation, insulin resistance and dysglycemia, and adipokines using immunoassays and enzymatic colorimetric procedures, blinded to case status.
RESULTS: Eighty-six participants developed incident radiographic eHOA. In the multivariate analyses adjusted for age, gender, race, smoking, and body mass index, and after adjustment for multiple analyses, incident radiographic eHOA was associated with elevated levels of interleukin-7 (risk ratio (RR) per SD = 1.30 [95% confidence interval (CI) 1.09, 1.55] p trend 0.01).
CONCLUSIONS: This exploratory study suggests an association of elevated interleukin-7, an inflammatory cytokine, with incident eHOA, while other cytokines or biomarkers of metabolic inflammation were not associated. Interleukin-7 may mediate inflammation and tissue damage in susceptible osteoarthritic finger joints and participate in erosive progression.