■由于需要延长静脉治疗,外周插入的中心静脉导管(PICC)广泛用于血液系统恶性肿瘤患者。然而,越来越多的PICCs的使用导致了许多并发症,如感染和血栓形成,导致住院时间延长和发病率增加。本研究旨在确定血液恶性肿瘤患者PICC相关并发症的发生率和相关因素。
■这项前瞻性队列研究是在一个学术机构进行的。纳入标准涉及所有新插入PICC的血液恶性肿瘤成年患者。观察患者的最小持续时间为60天,以评估PICC相关感染和血栓形成的发生率。以及机械并发症。
■85例患者共植入119个PICC。其中,超过一半的患者被诊断为淋巴瘤(55.0%).中位停留时间为61天(四分位距:98天)。PICC相关并发症的发生率为58.0%(6.9/1,000导管天)。具体来说,43个PICCs(36.1%,4.3/1,000导管-天)经历感染性并发症,25(21.1%,每1000个导管天2.5个)遇到机械性并发症和1个(0.8%,每1,000个导管天0.1个)出现血栓性并发症。此外,急性白血病的潜在诊断与PICC相关感染的发生率显著相关.
■我们的研究显示,与其他研究相比,成人血液系统恶性肿瘤患者PICC相关并发症的发生率更高。值得注意的是,潜在急性白血病患者的PICC相关感染发生率较高.这些发现强调了实施适当干预措施和进行彻底的根本原因分析以有效减轻这种并发症并改善患者预后的重要性。
UNASSIGNED: Peripherally inserted central venous catheters (PICC) are widely used in patients with haematological malignancies owing to the requirement for prolonged intravenous therapy. However, the growing use of PICCs has resulted in a multitude of complications such as infections and thrombosis, leading to prolonged hospitalisation periods and increased morbidity. This study aimed to determine the incidence of and factors associated with PICC-related complications in patients with haematological malignancies.
UNASSIGNED: This prospective cohort study was conducted at a single academic institution. The inclusion criteria involved all adult patients with haematological malignancies who had newly inserted PICCs. The patients were observed for a minimum duration of 60 days to evaluate the incidence of PICC-related infections and thrombosis, as well as mechanical complications.
UNASSIGNED: A total of 119 PICCs were implanted in 85 patients. Among them, more than half of the patients were diagnosed with lymphoma (55.0%). The median dwell time was 61 days (interquartile range: 98 days). The incidence of PICC-related complications was 58.0% (6.9 per 1,000 catheter-days). Specifically, 43 PICCs (36.1%, 4.3 per 1,000 catheter-days) experienced infective complications, 25 (21.1%, 2.5 per 1,000 catheter-days) encountered mechanical complications and 1 (0.8%, 0.1 per 1,000 catheter-days) exhibited thrombotic complications. Furthermore, an underlying diagnosis of acute leukaemia was significantly associated with a higher incidence of PICC-related infections.
UNASSIGNED: Our study revealed higher incidence rates of PICC-related complications in adult patients with haematological malignancies compared to the finding of other studies. Notably, patients with underlying acute leukaemia displayed a higher incidence of PICC-related infections. These findings underscore the importance of implementing appropriate interventions and conducting thorough root cause analyses to effectively mitigate this complication and improve patient outcomes.