背景:乳腺癌是全世界女性中最常见的癌症,在发展中国家死亡率明显不成比例。尽管乳腺癌的临床管理已经得到了极大的改善,在预后和复发标志物的细化仍是需要的。长链非编码RNA(lncRNA)HOTAIR最近与不良预后相关,并可能用作乳腺癌的预后标志物。
方法:我们全面回顾了评估lncRNAHOTAIR与乳腺癌总体和无病生存相关的研究。在Pubmed中进行了系统搜索,ProQuest,ScienceDirect,Scopus,谷歌学者,语义学者,Springer,自然,Sage日志,和Wiley数据库使用组合关键词“长链非编码RNA”,\"\"lncRNA,“”HOX转录本反义RNA,\"\"HOTAIR,\"\"乳房can-cer,“癌症妈妈,“\”预后,“和”生存。“偏见风险评分用于评估研究质量,进行I2检验以评估异质性。采用STATAv.17软件进行Meta分析比较HOTAIR表达与乳腺癌生存率。
结果:在总共1,504项筛选研究中,7项研究纳入了533例患者的荟萃分析.HOTAIR的高表达与低生存率相关(合并HR:1.69;95CI:1.11-2.59;p=0.015),总生存期(OS)较短(合并HR:1.33;95CI:0.78-2.26;p=0.455),无病生存率(DFS)(合并HR:2.40;95CI:1.63-3.53;p<0.001),无远处转移生存率(MFS)较差(HR:1.75;95CI:1.13-2.71;p=0.012)。此外,HOTAIR的过度表达与阳性淋巴结浸润(合并OR:2.38;95CI:0.53-10.69;p=0.26)和导管型癌症(合并OR:3.27;95CI:1.15-9.30;p=0.03)相关.
结论:lncRNAHOTAIR的上调与更差的DFS和MFS相关,这可能被用作乳腺癌患者的预后标志物。
BACKGROUND: Breast cancer is the most frequent cancer among women worldwide with significant disproportionate mortality rates in developing countries. Although clinical management of breast cancer has been immensely improved, refinement in the prognostic and recurrent markers is still needed. Long non-coding RNAs (lncRNA)
HOTAIR has recently been associated with poor outcome and is potentially used as a prognostic marker in breast cancer.
METHODS: We comprehensively reviewed studies evaluating lncRNA
HOTAIR in association with overall and disease-free survivals in breast cancers. Systematic searches were performed in Pubmed, ProQuest, ScienceDirect, Scopus, Google Scholar, Semantic Scholar, Springer, Nature, Sage Journals, and Wiley databases using combination keywords \"long non-coding RNA,\" \"lncRNA,\" \"HOX transcript antisense RNA,\" \"HOTAIR,\" \"breast can-cer,\" \"carcinoma mammae,\" \"prognosis,\" and \"survival.\" Risk of bias score was used to assess quality of studies, I2 test was conducted to assess heterogeneity. Meta-analysis was performed to compare
HOTAIR expression with breast cancer survival rates using STATA v.17 software.
RESULTS: Of the total 1,504 screened studies, seven studies were included in the meta-analysis involving 533 patients. High expression of
HOTAIR was associated with poor survival rates (pooled HR: 1.69; 95%CI: 1.11-2.59; p=0.015), shorter overall survival (OS) (pooled HR: 1.33; 95%CI: 0.78-2.26; p=0.455), poor disease-free survival (DFS) (pooled HR: 2.40; 95%CI: 1.63-3.53; p<0.001), poor distant metastatic-free survival (MFS) (HR: 1.75; 95%CI: 1.13-2.71; p=0.012). In addition, overexpression of
HOTAIR was associated with positive lymph node infiltration (pooled OR: 2.38; 95%CI: 0.53-10.69; p=0.26) and ductal type cancer (pooled OR: 3.27; 95%CI: 1.15-9.30; p=0.03).
CONCLUSIONS: Upregulation of lncRNA HOTAIR is associated with worse DFS aand MFS that can potentially be used as a prognostic marker in breast cancer patients.