背景:无菌性腹膜炎是局部免疫系统的反应,旨在排斥异物,which,具有抗原特性,不会(与病原体不同)抵消免疫系统。缝合材料,即羊肠线,用于腔内外科手术具有异种特性,可用于腹膜腔免疫系统的抗原刺激。因此,我们决定使用羊肠线缝合对腹膜腔的免疫系统进行抗原性刺激,并研究白化病大鼠无菌性腹膜炎实验模型结果的形态学特征。
方法:本研究涉及15只Wistar白化病雄性大鼠,重286,13±6,26g。为了研究实验动物腹膜腔中肠线植入物的破坏性变化的动力学,根据实验第3,7和14天安乐死的时间间隔,将动物分为三组。
结果:无菌性腹膜炎建模后,腹腔调查显示,第一组五只动物中有四只,也就是说,在实验的第三天,肠线植入物粘附在大网膜上。对第五个植入物的搜索导致了一个意想不到的发现:我们发现它与内脏腹膜的二阶导数相结合,结构类似于大网膜,但与睾丸有关.第7天,植入物嵌入动物的腹膜腔,在所有五种情况下都坚持睾丸的浆液形成(100%,其中三个-左侧附睾网膜,和另外两个-右边一个)。在第14天(n=5),发现在三种情况下,它已经粘附到睾丸的浆液形成(60%,其中一个在左附睾网膜,另外两个-向右一个),在两种情况下,它粘附在大网膜上(40%)。
结论:在将由羊肠线制成的扁平束形式的异种基质植入性成熟雄性大鼠腹膜腔的实验中,第一次发现它们的受体不仅是大网膜,还有腹膜的两种衍生物,与它同态并与附睾相关,我们合理地称之为附睾网膜并详细描述。
BACKGROUND: Aseptic peritonitis is a reaction of the local immune system aimed at rejection of a foreign body, which, having antigenic properties, does not (unlike a pathogen) counteract the immune system. The suture materials, namely catgut thread, used in intracavitary surgical operations possess xenogenic properties and can be used for antigenic stimulation of the immune system of the peritoneal cavity. Consequently, we decided to use a catgut suture for antigenic stimulation of the immune system of the peritoneal cavity and to study the morphological features of the results of experimental modeling of aseptic peritonitis in albino rats.
METHODS: The study involved 15 Wistar albino male rats, weighing 286,13 ± 6,26 g. To study the dynamics of destructive changes made by the catgut implant in the peritoneal cavity of the experimental animals, the animals were assigned into three groups in accordance with the time interval of their euthanasia at 3, 7, and 14 days of the experiment.
RESULTS: After modeling an aseptic peritonitis, the investigation the abdominal cavity showed that in four out of five animals of the first group, that is, on day 3 of the experiment, the catgut implant had adhered to the greater omentum. The search for the fifth implant led to an unexpected discovery: we found it conjoined with the second derivative of the visceral peritoneum, similar in structure to the greater omentum, but related to the testes. On day 7, the implant embedded into the peritoneal cavity of the animals, had adhered to the serous formations of the testes in all five cases (100%, three of them - to the left epididymal omentum, and another two - to the right one). On day 14 (n = 5) it was found that in three cases it had adhered to the serous formations of the testes (60%, one of them to the left epididymal omentum, another two - to the right one) and in two cases it had adhered to the greater omentum (40%).
CONCLUSIONS: During the experiment on implantation of a xenogenic substrate in the form of flat bundles made from the catgut thread into the peritoneal cavity of sexually mature male rats, it was found for the first time that their acceptors were not only the greater omentum, but also two derivatives of the peritoneum, homeomorphic to it and associated with the epididymides, which we reasonably called epididymal omenta and described in details.