■声动力疗法(SDT)作为一种新兴的肿瘤治疗方法获得了广泛的关注。然而,SDT过程中肿瘤血管的破坏和氧的消耗可能导致进一步的缺氧。这可能导致糖酵解增强,乳酸积累,和免疫抑制。
■构建了糖酵解抑制剂(3PO)负载和PEG修饰的黑磷纳米片(BO),用于有效的饥饿疗法和有效的免疫激活。
■在超声照射下,BO可以产生ROS破坏肿瘤和肿瘤血管,导致进一步的缺氧和营养物质阻断。然后,释放的3PO抑制肿瘤糖酵解并防止缺氧诱导的糖酵解和乳酸积累。SDT和3PO都可以切断乳酸的来源,以及通过阻断三磷酸腺苷(ATP)供应来实现抗肿瘤饥饿治疗。此外,饥饿治疗和SDT的结合进一步促进了树突状细胞(DC)的成熟,促进DC的抗原呈递,并最终传播抗肿瘤免疫和抑制肿瘤生长。
■这是首次将SDT与抑制糖酵解相结合,实现了令人钦佩的肿瘤治疗,减少了由SDT过程引起的不良事件,并引起了良好的免疫激活。我们的系统为未来抗肿瘤纳米药物的设计提供了新的思路。
UNASSIGNED: Sonodynamic therapy (SDT) as an emerging tumor treatment gained wide attention. However, tumor vascular destruction and oxygen depletion in SDT process may lead to further hypoxia. This may lead to enhanced glycolysis, lactate accumulation, and immunosuppression.
UNASSIGNED: A glycolysis inhibitor (3PO) loaded and PEG modified black phosphorus nanosheets (BO) is constructed for potent starvation therapy and efficient immune activation.
UNASSIGNED: Under ultrasound irradiation, the BO can produce ROS to destroy tumors and tumor blood vessels and lead to further hypoxia and nutrients block. Then, the released 3PO inhibits tumor glycolysis and prevents the hypoxia-induced glycolysis and lactate accumulation. Both SDT and 3PO can cut off the source of lactic acid, as well as achieve antitumor starvation therapy through the blockade of the adenosine triphosphate (ATP) supply. In addition, the combination of starvation treatment and SDT further facilitates dendritic cells (DC) maturation, promotes antigen presentation by DCs, and eventually propagates the antitumor immunity and inhibition of abscopal tumor growth.
UNASSIGNED: This is the first time that combines SDT with inhibition of glycolysis, achieving admirable tumor treatment and decreasing adverse events caused by SDT process and that has caused good immune activation. Our system provides a new idea for the future design of anti-tumor nanomedicines.