2型糖尿病(T2DM),以胰岛素抵抗和葡萄糖代谢异常为特征,是一种主要的代谢紊乱,伴随着健康和经济负担。最近,研究结果表明,橘皮提取物(OPE)具有改善胰岛素敏感性和葡萄糖代谢等健康益处。本研究旨在确定OPE中柚皮苷对T2DM诱导的糖脂代谢异常的作用。30只雄性(30只)Wistar大鼠随机分为5组:对照组,糖尿病,糖尿病+柚皮苷,糖尿病+橘皮,和糖尿病+二甲双胍。口服给药每天一次,持续28天。治疗28天后,柚皮苷改善了糖尿病引起的血糖升高,稳态模型评估(HOMA)IR,甘油三酯,总胆固醇,甘油三酯/高密度脂蛋白,总胆固醇/高密度脂蛋白,甘油三酯葡萄糖指数,葡萄糖合成酶激酶-3,乳酸,乳酸脱氢酶,丙二醛,c反应蛋白,和肿瘤坏死因子α与未治疗的糖尿病动物相比。此外,柚皮苷逆转糖尿病诱导的血清胰岛素下降,HOMAB,HOMAS,定量胰岛素敏感性检查指数,高密度脂蛋白,总抗氧化能力,超氧化物歧化酶,过氧化氢酶,葡萄糖转运蛋白4和肝糖原。这项研究表明,柚皮苷通过葡萄糖合酶激酶-3和氧化应激依赖性途径预防糖尿病诱导的血糖和血脂异常。
Type 2 diabetes mellitus (T2DM), characterized by insulin resistance and glucose dysmetabolism, is a major metabolic disorder accompanied with health and financial burden. Recently, research findings showed that orange peel extract (OPE) has health benefits such as improved insulin sensitivity and glucose metabolism. The present study aimed at establishing the role of naringin from OPE on T2DM-induced glucose and lipid dysmetabolism. Thirty male (30) Wistar rats were randomized into five groups: control, diabetes, diabetes + naringin, diabetes + orange peel, and diabetes + metformin. Oral administration was once per day for 28 days. After 28 days of treatment, naringin ameliorated the diabetes-induced increase in blood sugar, homeostatic model assessment (HOMA) IR, triglyceride, total cholesterol, triglyceride/high density lipoprotein, total cholesterol/high density lipoprotein, triglyceride glucose index, glucose synthase kinase-3, lactate, lactate dehydrogenase, malondialdehyde, c-reactive protein, and tumor necrosis factor α compared with the diabetic untreated animals. Furthermore, naringin reversed diabetes-induced decrease in serum insulin, HOMA B, HOMA S, quantitative insulin-sensitivity check index, high-density lipoprotein, total antioxidant capacity, superoxide dismutase, catalase, glucose transporter-4, and hepatic glycogen. This study showed that naringin prevented diabetes-induced dysglycemia and dyslipidemia via glucose synthase kinase-3 and oxidative stress-dependent pathways.